Skip Header

Contribute Send feedback
Read comments (?) or add your own

A1BE99 (A1BE99_CHLPD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315
Ordered Locus Names:Cpha266_0671
OrganismChlorobium phaeobacteroides (strain DSM 266) [Complete proteome] [HAMAP]
Taxonomic identifier290317 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
A1BE99 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 5C48485745F9A124

FASTA64369,774
        10         20         30         40         50         60 
MEDSIPVPVS QESSILASIH SPEDLKKLSL EDLQHVADEC RREVINLVAQ NGGHFASSLG 

        70         80         90        100        110        120 
VVELSVALHY VYNSPRDKIV WDVGHQAYIH KILTGRRESM KTNRQYGGLA GFPRIFESPY 

       130        140        150        160        170        180 
DAFGTGHAST SISAAAGMAA ARDLSGGTEK MIAVIGDGSM TGGMAFEAMN HLGDTKSDVL 

       190        200        210        220        230        240 
VILNDNQMAI SPSTGGLKTH LVNIALNKTY NKTRKFIWNS ISLLNNDLGD TAKSLVRKLE 

       250        260        270        280        290        300 
DGIKAAFTPG AFFEALGLRY FGPIDGHNLE QLVKALKEMQ ELPHPKLLHV VTTKGKGFKP 

       310        320        330        340        350        360 
AEENQSKWHA HNGGFDTTTG KTIVTAQKAG PPKYQEVFGE TLVELALKDP RITAITAAMP 

       370        380        390        400        410        420 
SGTSLDLFQN ALPNRFFDVG IAEQHAVTFA AGLAIQGFKP VCAIYSTFLQ RGYDQIIHDV 

       430        440        450        460        470        480 
AQQNLHVVFA IDRAGLVGED GPTHHGAFDL SFLQPIPNFV IMAPSDEQEL RNMLYTALYH 

       490        500        510        520        530        540 
VTGPVAIRYP RGNGTGIALN KTLIPLEIGK GRIIRQGNGI ALLAAGPLVW RALEVAEALQ 

       550        560        570        580        590        600 
KEGMNPLVAD MRFIKPLDTE LIEEIAQQVT HLVVIEENSM IGGLGSGVID YINSRKSKIP 

       610        620        630        640 
VLKTGLPDAF VTHGSMEELY RETGLDVVGI TKSIKDFYPG NVT

« Hide

References

[1]"Complete sequence of Chlorobium phaeobacteroides DSM 266."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 266.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000492 Genomic DNA. Translation: ABL64726.1.
RefSeqYP_911150.1. NC_008639.1.

3D structure databases

ProteinModelPortalA1BE99.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1BE99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4569825.
GenomeReviewsGene locus Cpha266_0671 in contig CP000492_GR.
KEGGcph:Cpha266_0671.
NMPDRfig|290317.7.peg.704.
PATRIC21389163. VBIChlPha122104_0766.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMAQYDISYM.
PhylomeDBA1BE99.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1BE99_CHLPD
AccessionPrimary (citable) accession number: A1BE99
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info