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A1BE85

- PUR9_CHLPD

UniProt

A1BE85 - PUR9_CHLPD

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Chlorobium phaeobacteroides (strain DSM 266)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciCPHA290317:GHX4-669-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Cpha266_0657
    OrganismiChlorobium phaeobacteroides (strain DSM 266)
    Taxonomic identifieri290317 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
    ProteomesiUP000008701: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Bifunctional purine biosynthesis protein PurHPRO_1000018872Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290317.Cpha266_0657.

    Structurei

    3D structure databases

    ProteinModelPortaliA1BE85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiIRASSKN.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1BE85-1 [UniParc]FASTAAdd to Basket

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    MSDPVIKRAL VSVSDKTGIV DFCRELSLLG VEVFSTGGTL KTLQDAGIAA    50
    ASISTITGFP EIMDGRVKTL HPKIHGGLLA VRENPDHVNQ ANENGISFID 100
    LVVVNLYPFE ATVAKPDVTF EDAIENIDIG GPSMLRSAAK NNESVTVVTD 150
    SADYALVLQE MRNNNGATKR ETRLALALKV FELTSRYDRA IASYLAGAQH 200
    EADSSMTVKL ERELDMRYGE NPHQSAGLYR LTDENGTRSF SDYFEKLHGK 250
    ELSYNNMLDI AAAVSLIEEF RGEEPTVVII KHTNPCGVAQ APTLAEAYRR 300
    AFSTDTQAPF GGIIAFNHPL DMEAATAVNE IFTEILIAPA FEDGVLEMLM 350
    KKKDRRLVRQ TSALPKGGWE FKSTPFGMLV QERDSKIVTK EDLTVVTKRQ 400
    PTEEEVADMM FAWKICKHIK SNTILYVKNR QTFGVGAGQM SRVDSSKIAR 450
    WKASEVNLDL HGSVVASDAF FPFADGLLAA AEAGVTAVIQ PGGSIRDNEV 500
    IEAADANNLA MVFTGMRHFK H 521
    Length:521
    Mass (Da):57,053
    Last modified:January 23, 2007 - v1
    Checksum:i9CAAAFA3D2B081E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000492 Genomic DNA. Translation: ABL64712.1.
    RefSeqiWP_011744542.1. NC_008639.1.
    YP_911136.1. NC_008639.1.

    Genome annotation databases

    EnsemblBacteriaiABL64712; ABL64712; Cpha266_0657.
    GeneIDi4569811.
    KEGGicph:Cpha266_0657.
    PATRICi21389133. VBIChlPha122104_0751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000492 Genomic DNA. Translation: ABL64712.1 .
    RefSeqi WP_011744542.1. NC_008639.1.
    YP_911136.1. NC_008639.1.

    3D structure databases

    ProteinModelPortali A1BE85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290317.Cpha266_0657.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL64712 ; ABL64712 ; Cpha266_0657 .
    GeneIDi 4569811.
    KEGGi cph:Cpha266_0657.
    PATRICi 21389133. VBIChlPha122104_0751.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi IRASSKN.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci CPHA290317:GHX4-669-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chlorobium phaeobacteroides DSM 266."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 266.

    Entry informationi

    Entry nameiPUR9_CHLPD
    AccessioniPrimary (citable) accession number: A1BE85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3