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A1BE22 (A1BE22_CHLPD) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224
Gene names
Name:pyrD HAMAP MF_00224
Ordered Locus Names:Cpha266_0593
OrganismChlorobium phaeobacteroides (strain DSM 266) [Complete proteome] [HAMAP]
Taxonomic identifier290317 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224

Catalytic activity

(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224

Cofactor

Binds 1 FMN per subunit By similarity. HAMAP MF_00224 SAAS SAAS012135

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224

Subcellular location

Cytoplasm By similarity HAMAP MF_00224.

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1401Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

Sequence LengthMass (Da)Tools
A1BE22 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 16C7A33E141F202F

FASTA31433,296
        10         20         30         40         50         60 
MTDHIPVEKT SITGISLGRG LELRSPVLLA SGTVSYGEEL NTLCDLGKIG GLVTKAISLE 

        70         80         90        100        110        120 
PRTGNPPQRI AETPSGMVNA IGLANVGVKK FITEKAPFLR KLNTAIIVNI AGRSIDEYAE 

       130        140        150        160        170        180 
VIARLDDVEG IGGYEINLSC PNVKGECMIM GVSRSATHEI VSVLRKITNR HLMIKLTPNV 

       190        200        210        220        230        240 
TSISSIALAA EEAGADSVSL INTLVGMAVN YKTRKPLLRN VTGGLSGPAI KPIALAKVWE 

       250        260        270        280        290        300 
VFNAVNIPVV GMGGITGFED AMEFLLVGAT AIQIGTMNFV YPDIGEKTAV ALEKHFSMPD 

       310 
APNIKEYIGS LITE

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References

[1]"Complete sequence of Chlorobium phaeobacteroides DSM 266."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 266.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000492 Genomic DNA. Translation: ABL64649.1.
RefSeqYP_911073.1. NC_008639.1.

3D structure databases

ProteinModelPortalA1BE22.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1BE22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4568713.
GenomeReviewsGene locus Cpha266_0593 in contig CP000492_GR.
KEGGcph:Cpha266_0593.
NMPDRfig|290317.7.peg.623.
PATRIC21388981. VBIChlPha122104_0676.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0167.
HOGENOMHBG472415.
OMAVALRMVW.
PhylomeDBA1BE22.
ProtClustDBCLSK637846.

Family and domain databases

HAMAPMF_00224. DHO_dh_type1.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsTIGR01037. PyrD_sub1_fam. 1 hit.
PROSITEPS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1BE22_CHLPD
AccessionPrimary (citable) accession number: A1BE22
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info