Reviewed,
UniProtKB/Swiss-Prot A1BE04 (DAPA_CHLPD)
Last modified
November 3, 2009.
Version 23.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydrodipicolinate synthase Short name=DHDPS EC=4.2.1.52 | ||||
| Gene names |
| ||||
| Organism | Chlorobium phaeobacteroides (strain DSM 266) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 290317 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium |
Protein attributes
| Sequence length | 296 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418 |
| Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418 |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the DHDPS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Schiff base |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | dihydrodipicolinate synthase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 296 | 296 | Dihydrodipicolinate synthase HAMAP MF_00418 | PRO_1000050175 | |||||
Regions | |||||||||
| Region | 52 – 53 | 2 | Pyruvate binding By similarity | ||||||
Sites | |||||||||
| Active site | 166 | 1 | Schiff-base intermediate with substrate By similarity | ||||||
| Binding site | 110 | 1 | Pyruvate By similarity | ||||||
| Site | 137 | 1 | Involved in proton transfer during cleavage By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence of Chlorobium phaeobacteroides DSM 266." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000492 Genomic DNA. Translation: ABL64631.1. | |
| RefSeq | YP_911055.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A1BE04. |
Genome annotation databases | |
| GeneID | 4569170. |
| GenomeReviews | Gene locus Cpha266_0575 in contig CP000492_GR. |
| KEGG | cph:Cpha266_0575. |
| NMPDR | fig|290317.7.peg.603. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | VAPRLMH. |
Family and domain databases | |
| HAMAP | MF_00418. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR005263. DapA_synth. IPR002220. DHDPS. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR12128. DHDPS. 1 hit. |
| Pfam | PF00701. DHDPS. 1 hit. [Graphical view] |
| PRINTS | PR00146. DHPICSNTHASE. |
| ProDom | PD001859. DHDPS. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00674. dapA. 1 hit. |
| PROSITE | PS00665. DHDPS_1. False negative. PS00666. DHDPS_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DAPA_CHLPD | ||||||||
| Accession | Primary (citable) accession number: A1BE04 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


