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A1BE03

- GCSPA_CHLPD

UniProt

A1BE03 - GCSPA_CHLPD

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Cpha266_0574
Organism
Chlorobium phaeobacteroides (strain DSM 266)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCPHA290317:GHX4-585-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Cpha266_0574
OrganismiChlorobium phaeobacteroides (strain DSM 266)
Taxonomic identifieri290317 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000008701: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045642Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi290317.Cpha266_0574.

Structurei

3D structure databases

ProteinModelPortaliA1BE03.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiYVRKIPG.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A1BE03-1 [UniParc]FASTAAdd to Basket

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MPFIVNTDQD TREMLSVLGA ASFDELIPDI PEEIRLKKAL DLFPAMSEQE    50
VKRLLEGLAS SNTSTSDYVS YLGGGAYDHF IPSAIKTIVS RSEFYTAYTP 100
YQAEVSQGTL QAIYEYQSLM CRLYDMDVAN ASMYDGATAL AEAVLMAISV 150
TGRQEVIVAG KLHPHYCEVL KTYLEAGGHS AVVQNTLENG VGTLDGLGAL 200
LTDRCAAVIV QQPNFYGSLE DVEAIGELAH SKGALFVVSA DPVSLGLLAA 250
PGSYGADIAV GEGQPLGNAQ SFGGPYLGIF TVKQDLVRKI PGRLVGMTKD 300
RNGDDGFILT LQTREQHIRR EKATSNICTN QALNALHAAI YLSLLGKQGI 350
IDVAEQSALK SHYLAEQIAD IPGFSLKYSA PFFREFVVET PMAAREVISN 400
LLEKKIFAGC DLSVYDEAGL LVAVTEKRTK AELDAFVEYL GALK 444
Length:444
Mass (Da):47,961
Last modified:January 23, 2007 - v1
Checksum:i3BF40A626F902968
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000492 Genomic DNA. Translation: ABL64630.1.
RefSeqiWP_011744463.1. NC_008639.1.
YP_911054.1. NC_008639.1.

Genome annotation databases

EnsemblBacteriaiABL64630; ABL64630; Cpha266_0574.
GeneIDi4569169.
KEGGicph:Cpha266_0574.
PATRICi21388937. VBIChlPha122104_0654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000492 Genomic DNA. Translation: ABL64630.1 .
RefSeqi WP_011744463.1. NC_008639.1.
YP_911054.1. NC_008639.1.

3D structure databases

ProteinModelPortali A1BE03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290317.Cpha266_0574.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL64630 ; ABL64630 ; Cpha266_0574 .
GeneIDi 4569169.
KEGGi cph:Cpha266_0574.
PATRICi 21388937. VBIChlPha122104_0654.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi YVRKIPG.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CPHA290317:GHX4-585-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chlorobium phaeobacteroides DSM 266."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 266.

Entry informationi

Entry nameiGCSPA_CHLPD
AccessioniPrimary (citable) accession number: A1BE03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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