UniProtKB - A1BDY0 (SYL_CHLPD)
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Protein
Leucine--tRNA ligase
Gene
leuS
Organism
Chlorobium phaeobacteroides (strain DSM 266)
Status
Functioni
Catalytic activityi
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 579 | ATPUniRule annotation | 1 |
GO - Molecular functioni
- aminoacyl-tRNA editing activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- leucine-tRNA ligase activity Source: UniProtKB-EC
GO - Biological processi
- leucyl-tRNA aminoacylation Source: InterPro
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | CPHA290317:G1G7N-582-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)Alternative name(s): Leucyl-tRNA synthetaseUniRule annotation Short name: LeuRSUniRule annotation |
Gene namesi | Name:leuSUniRule annotation Ordered Locus Names:Cpha266_0551 |
Organismi | Chlorobium phaeobacteroides (strain DSM 266) |
Taxonomic identifieri | 290317 [NCBI] |
Taxonomic lineagei | Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000009322 | 1 – 816 | Leucine--tRNA ligaseAdd BLAST | 816 |
Structurei
3D structure databases
ProteinModelPortali | A1BDY0. |
SMRi | A1BDY0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 40 – 51 | "HIGH" regionAdd BLAST | 12 | |
Motifi | 576 – 580 | "KMSKS" region | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105C8T. Bacteria. COG0495. LUCA. |
HOGENOMi | HOG000200748. |
KOi | K01869. |
OMAi | TFMVLAP. |
OrthoDBi | POG091H01JZ. |
Family and domain databases
Gene3Di | 3.40.50.620. 2 hits. 3.90.740.10. 1 hit. |
HAMAPi | MF_00049_B. Leu_tRNA_synth_B. 1 hit. |
InterProi | View protein in InterPro IPR002300. aa-tRNA-synth_Ia. IPR002302. Leu-tRNA-ligase. IPR025709. Leu_tRNA-synth_edit. IPR013155. M/V/L/I-tRNA-synth_anticd-bd. IPR015413. Methionyl/Leucyl_tRNA_Synth. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_Ia_anticodon-bd. IPR009008. Val/Leu/Ile-tRNA-synth_edit. |
PANTHERi | PTHR43740. PTHR43740. 2 hits. |
Pfami | View protein in Pfam PF08264. Anticodon_1. 1 hit. PF00133. tRNA-synt_1. 1 hit. PF13603. tRNA-synt_1_2. 1 hit. PF09334. tRNA-synt_1g. 1 hit. |
PRINTSi | PR00985. TRNASYNTHLEU. |
SUPFAMi | SSF47323. SSF47323. 1 hit. SSF50677. SSF50677. 1 hit. |
TIGRFAMsi | TIGR00396. leuS_bact. 1 hit. |
i Sequence
Sequence statusi: Complete.
A1BDY0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRYDFSTIEK KWQSFWLKNN SFSSGESTDK PKYYVLDMFP YPSGSGLHVG
60 70 80 90 100
HLEGYTATDI VARYKRSCGY NVLHPMGWDA FGLPAEQFAI KTGTHPKNTT
110 120 130 140 150
EKNISSFRET LQAMGFSYDW SREINTTSPD YFRWTQWIFI KLYELGLAYV
160 170 180 190 200
SEVDINWCEE LKTVLANEEV EEKVKEGYTV IRKPLRQWVL KITAYAERLL
210 220 230 240 250
DDLDELDWPE NVKQMQRNWI GRSEGMEIDF ELRCHNRKLR VYTTRPDTLF
260 270 280 290 300
GATFLVISPE HPLALKLATA QQLVAVTQYI KEAKLKSELE RTGLQKDKTG
310 320 330 340 350
IFTGSFAINP ATGDPLPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF
360 370 380 390 400
GLPIIEVIKS PDGVDDAAFE GKESVSINSS NPEISIDGLH FSEAFQIMAH
410 420 430 440 450
WLETKGLGER KVTYKLRDWI FSRQRYWGEP IPVKHYEDGS IRTESNLPLQ
460 470 480 490 500
LPEVEAYQPS ETGESPLATM HDWLYGADEF GSFRRETNTM PQWAGSCWYY
510 520 530 540 550
LRFIDPENNA QLIDPAKEKY WMNVDLYIGG AEHAVLHLLY ARFWHKVLYD
560 570 580 590 600
LGVVSSREPF KKLFNQGMIL GEDNEKMSKS RGNVIPADQV LKDYGADAVR
610 620 630 640 650
LYEMFLGPLE QVKPWNTNGI EGISRFLGKV WRLVYPDSEN PDQRDQAAVL
660 670 680 690 700
DENPLPEILQ RRMHKTIKKV TEDTDHLKFN TAISEMMVFV NELQKNGCRQ
710 720 730 740 750
KSAVENLLLM LAPYAPHITA ELWQAIGHTS PISAEPFPVF DPAIAEDPVV
760 770 780 790 800
TIAVQVNGKL RGRFTAPAKS PEESLVDMAK HVDTVIKFLE GQTIVKEIVI
810
QDKLVNFAVK QSIPNH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000492 Genomic DNA. Translation: ABL64607.1. |
RefSeqi | WP_011744440.1. NC_008639.1. |
Genome annotation databases
EnsemblBacteriai | ABL64607; ABL64607; Cpha266_0551. |
KEGGi | cph:Cpha266_0551. |
Similar proteinsi
Entry informationi
Entry namei | SYL_CHLPD | |
Accessioni | A1BDY0Primary (citable) accession number: A1BDY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 28, 2018 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |