A1BDV6 (LPXK_CHLPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetraacyldisaccharide 4'-kinase
EC=2.7.1.130

Alternative name(s):
Lipid A 4'-kinase

Gene names

Name:	lpxK
Ordered Locus Names:	Cpha266_0526

Organism

Chlorobium phaeobacteroides (strain DSM 266) [Complete proteome] [HAMAP]

Taxonomic identifier

290317 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) By similarity. HAMAP MF_00409
Catalytic activity	ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate). HAMAP MF_00409
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. HAMAP MF_00409
Sequence similarities	Belongs to the LpxK family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tetraacyldisaccharide 4'-kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Tetraacyldisaccharide 4'-kinase HAMAP MF_00409		PRO_1000080464
Regions
	Nucleotide binding	49 – 56	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A1BDV6 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 117C0E7E367542DF	FASTA	355	39,481
	10 20 30 40 50 60 MSFDLPDIIL RPASLLYKNI IRIRNRLYDQ QIFHTWHSPL PIVSIGNISA GGTGKTPLVD 70 80 90 100 110 120 WIVKYYLSLG CKPAIVSRGY GRNTKGVQLV SDGKTVLMKS NACGDETAML AWNNRDAIVI 130 140 150 160 170 180 VAEKRKDAVT FIIRRFAEAM PDVIILDDAF QHRQIARNLD IVVINEKEPY FRADMIPKGR 190 200 210 220 230 240 LREPLINLAR ADLLVLSKIT GGSTTAAISM DLEQTGKPVI KAGIAAGNLV CLSGMFNTAK 250 260 270 280 290 300 ESPVHAGIKA LAFAGIGSPQ SFIDTLEGQG IQIVSHRFFR DHESYTAKKI AALRLEADEK 310 320 330 340 350 KLTLVTTEKD YFRMLGQPEL QEILHTLSCC YLKIRPEFTE GEKLLKTMLN AVINR

References

[1]

"Complete sequence of Chlorobium phaeobacteroides DSM 266." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 266.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000492 Genomic DNA. Translation: ABL64583.1.
RefSeq	YP_911007.1. NC_008639.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1BDV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4569121.
GenomeReviews	Gene locus Cpha266_0526 in contig CP000492_GR.
KEGG	cph:Cpha266_0526.
NMPDR	fig|290317.7.peg.549.
PATRIC	21388827. VBIChlPha122104_0599.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1663.
HOGENOM	HBG663914.
OMA	VILMDDG.
PhylomeDB	A1BDV6.
ProtClustDB	CLSK637887.
Family and domain databases
HAMAP	MF_00409. LpxK. [Tree]
InterPro	IPR003758. Tetraacyldisaccharide_4-kinase. [Graphical view]
KO	K00912.
Pfam	PF02606. LpxK. 1 hit. [Graphical view]
TIGRFAMs	TIGR00682. LpxK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXK_CHLPD

Accession

Primary (citable) accession number: A1BDV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program