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Protein

Adenylosuccinate lyase

Gene

Pden_4463

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (Pden_4463)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Pden_4463)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciPDEN318586:G1GW1-5123-MONOMER
UniPathwayiUPA00074; UER00132
UPA00075; UER00336

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Ordered Locus Names:Pden_4463Imported
OrganismiParacoccus denitrificans (strain Pd 1222)Imported
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 2

PTM / Processingi

Proteomic databases

PRIDEiA1BAI3

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_4463

Structurei

3D structure databases

ProteinModelPortaliA1BAI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 432ADSL_CInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTF Bacteria
COG0015 LUCA
HOGENOMiHOG000033912
KOiK01756
OMAiASSCEKI
OrthoDBiPOG091H0168

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR019468 AdenyloSucc_lyase_C
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR004769 Pur_lyase
PfamiView protein in Pfam
PF10397 ADSL_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SMARTiView protein in SMART
SM00998 ADSL_C, 1 hit
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00928 purB, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A1BAI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPRYARPEM TAIWSPETRF RIWYEIEAHA CDAQADLGVI PRENAEAVWK
60 70 80 90 100
ARDVEFDVAR IDEIEAVTKH DVIAFLTHLA EHIGAEEARF VHQGMTSSDV
110 120 130 140 150
LDTTLNVQLV RAADILLADM DKVLAALKKR AYEHKNTVRI GRSHGIHAEP
160 170 180 190 200
TTMGLTFARF YAEMARGRER LERARDEVAT GAISGAVGTF ANIDPRVEEH
210 220 230 240 250
VCAKMGLSPE PISTQVIPRD RHAMFFATLG VIASSIENIA IEIRHMQRTE
260 270 280 290 300
VLEAEEYFSP GQKGSSAMPH KRNPVLTENL TGLARLVRMA VVPAMENVAL
310 320 330 340 350
WHERDISHSS VERGIAPDAT ITLDFALNRL AGVIEKLVVY PENMLKNMNK
360 370 380 390 400
FKGLVMSQRV LLALTQAGVS REDAYRLVQR NAMKVWEQGA DFKTELLADA
410 420 430
EVTAALSPAE IEEKFDLGYH TKHVDTIFAR VFGENGAH
Length:438
Mass (Da):48,924
Last modified:January 23, 2007 - v1
Checksum:iF36557CFCD859086
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000490 Genomic DNA Translation: ABL72527.1
RefSeqiWP_011750688.1, NC_008687.1

Genome annotation databases

EnsemblBacteriaiABL72527; ABL72527; Pden_4463
KEGGipde:Pden_4463

Similar proteinsi

Entry informationi

Entry nameiA1BAI3_PARDP
AccessioniPrimary (citable) accession number: A1BAI3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health