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A1BA17

- GCH4_PARDP

UniProt

A1BA17 - GCH4_PARDP

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei183 – 1831May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPDEN318586:GCVQ-4340-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Pden_4297
    OrganismiParacoccus denitrificans (strain Pd 1222)
    Taxonomic identifieri318586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
    ProteomesiUP000000361: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321GTP cyclohydrolase FolE2PRO_0000289503Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi318586.Pden_4297.

    Structurei

    3D structure databases

    ProteinModelPortaliA1BA17.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiLSGWQYY.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1BA17-1 [UniParc]FASTAAdd to Basket

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    MTEARPVATE RAYPALSREY PADFRVDDSY KASLPDLQNG PASLIVGARA    50
    PIQHVGISNF RLPIRYQTQE GGEIALETSV TGTVSLEADR KGINMSRIMR 100
    SFYAHAEKQF SMGVLEAALE DYKSDLGSFD ARIMMRLSYP MRVESLRSGL 150
    SGWQYYDIAL ELSERAGQRL RIMHFDYVYS STCPCSLELA EHARQMRGQL 200
    ATPHSQRSIA RISVVMQGDT LWFEDMVTLC RRAVATETQV MVKREDEQAF 250
    AELNAANPIF VEDAVRAFAA ELMAEPRIGD FRVVASHQES LHSHDAVSVL 300
    TQGETFAHAS LDPAIFAGLR A 321
    Length:321
    Mass (Da):35,803
    Last modified:January 23, 2007 - v1
    Checksum:i6AC59623A06AB64E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000490 Genomic DNA. Translation: ABL72361.1.
    RefSeqiYP_918057.1. NC_008687.1.

    Genome annotation databases

    EnsemblBacteriaiABL72361; ABL72361; Pden_4297.
    GeneIDi4582847.
    KEGGipde:Pden_4297.
    PATRICi22859792. VBIParDen97112_4249.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000490 Genomic DNA. Translation: ABL72361.1 .
    RefSeqi YP_918057.1. NC_008687.1.

    3D structure databases

    ProteinModelPortali A1BA17.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318586.Pden_4297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL72361 ; ABL72361 ; Pden_4297 .
    GeneIDi 4582847.
    KEGGi pde:Pden_4297.
    PATRICi 22859792. VBIParDen97112_4249.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi LSGWQYY.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PDEN318586:GCVQ-4340-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pd 1222.

    Entry informationi

    Entry nameiGCH4_PARDP
    AccessioniPrimary (citable) accession number: A1BA17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3