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A1BA17

- GCH4_PARDP

UniProt

A1BA17 - GCH4_PARDP

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Pden_4297
Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei183 – 1831May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-4340-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Pden_4297
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321GTP cyclohydrolase FolE2UniRule annotationPRO_0000289503Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_4297.

Structurei

3D structure databases

ProteinModelPortaliA1BA17.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiLSGWQYY.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1BA17-1 [UniParc]FASTAAdd to Basket

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MTEARPVATE RAYPALSREY PADFRVDDSY KASLPDLQNG PASLIVGARA    50
PIQHVGISNF RLPIRYQTQE GGEIALETSV TGTVSLEADR KGINMSRIMR 100
SFYAHAEKQF SMGVLEAALE DYKSDLGSFD ARIMMRLSYP MRVESLRSGL 150
SGWQYYDIAL ELSERAGQRL RIMHFDYVYS STCPCSLELA EHARQMRGQL 200
ATPHSQRSIA RISVVMQGDT LWFEDMVTLC RRAVATETQV MVKREDEQAF 250
AELNAANPIF VEDAVRAFAA ELMAEPRIGD FRVVASHQES LHSHDAVSVL 300
TQGETFAHAS LDPAIFAGLR A 321
Length:321
Mass (Da):35,803
Last modified:January 23, 2007 - v1
Checksum:i6AC59623A06AB64E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000490 Genomic DNA. Translation: ABL72361.1.
RefSeqiYP_918057.1. NC_008687.1.

Genome annotation databases

EnsemblBacteriaiABL72361; ABL72361; Pden_4297.
GeneIDi4582847.
KEGGipde:Pden_4297.
PATRICi22859792. VBIParDen97112_4249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000490 Genomic DNA. Translation: ABL72361.1 .
RefSeqi YP_918057.1. NC_008687.1.

3D structure databases

ProteinModelPortali A1BA17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_4297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL72361 ; ABL72361 ; Pden_4297 .
GeneIDi 4582847.
KEGGi pde:Pden_4297.
PATRICi 22859792. VBIParDen97112_4249.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi LSGWQYY.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PDEN318586:GCVQ-4340-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiGCH4_PARDP
AccessioniPrimary (citable) accession number: A1BA17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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