Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathway: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei183 – 1831May be catalytically importantUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-4340-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Pden_4297
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321GTP cyclohydrolase FolE2PRO_0000289503Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_4297.

Structurei

3D structure databases

ProteinModelPortaliA1BA17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiLSGWQYY.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1BA17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEARPVATE RAYPALSREY PADFRVDDSY KASLPDLQNG PASLIVGARA
60 70 80 90 100
PIQHVGISNF RLPIRYQTQE GGEIALETSV TGTVSLEADR KGINMSRIMR
110 120 130 140 150
SFYAHAEKQF SMGVLEAALE DYKSDLGSFD ARIMMRLSYP MRVESLRSGL
160 170 180 190 200
SGWQYYDIAL ELSERAGQRL RIMHFDYVYS STCPCSLELA EHARQMRGQL
210 220 230 240 250
ATPHSQRSIA RISVVMQGDT LWFEDMVTLC RRAVATETQV MVKREDEQAF
260 270 280 290 300
AELNAANPIF VEDAVRAFAA ELMAEPRIGD FRVVASHQES LHSHDAVSVL
310 320
TQGETFAHAS LDPAIFAGLR A
Length:321
Mass (Da):35,803
Last modified:January 23, 2007 - v1
Checksum:i6AC59623A06AB64E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000490 Genomic DNA. Translation: ABL72361.1.
RefSeqiWP_011750523.1. NC_008687.1.
YP_918057.1. NC_008687.1.

Genome annotation databases

EnsemblBacteriaiABL72361; ABL72361; Pden_4297.
KEGGipde:Pden_4297.
PATRICi22859792. VBIParDen97112_4249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000490 Genomic DNA. Translation: ABL72361.1.
RefSeqiWP_011750523.1. NC_008687.1.
YP_918057.1. NC_008687.1.

3D structure databases

ProteinModelPortaliA1BA17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318586.Pden_4297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL72361; ABL72361; Pden_4297.
KEGGipde:Pden_4297.
PATRICi22859792. VBIParDen97112_4249.

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiLSGWQYY.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciPDEN318586:GCVQ-4340-MONOMER.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiGCH4_PARDP
AccessioniPrimary (citable) accession number: A1BA17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.