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A1B9S8

- A1B9S8_PARDP

UniProt

A1B9S8 - A1B9S8_PARDP

Protein

Acetate kinase

Gene

ackA

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

    Catalytic activityi

    ATP + acetate = ADP + acetyl phosphate.UniRule annotation

    Cofactori

    Mg2+. Can also accept Mn2+.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi9 – 91MagnesiumUniRule annotation
    Binding sitei16 – 161ATPUniRule annotation
    Binding sitei87 – 871SubstrateUniRule annotation
    Active sitei145 – 1451Proton donor/acceptorUniRule annotation
    Sitei176 – 1761Transition state stabilizerUniRule annotation
    Sitei236 – 2361Transition state stabilizerUniRule annotation
    Metal bindingi354 – 3541MagnesiumUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi203 – 2075ATPUniRule annotation
    Nucleotide bindingi323 – 3275ATPUniRule annotation

    GO - Molecular functioni

    1. acetate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
    2. organic acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPDEN318586:GCVQ-4250-MONOMER.
    UniPathwayiUPA00340; UER00458.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
    Alternative name(s):
    AcetokinaseUniRule annotation
    Gene namesi
    Name:ackAUniRule annotation
    Ordered Locus Names:Pden_4208Imported
    OrganismiParacoccus denitrificans (strain Pd 1222)Imported
    Taxonomic identifieri318586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
    ProteomesiUP000000361: Chromosome 2

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiA1B9S8.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi318586.Pden_4208.

    Structurei

    3D structure databases

    ProteinModelPortaliA1B9S8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0282.
    HOGENOMiHOG000288399.
    KOiK00925.
    OMAiFHRGHPF.
    OrthoDBiEOG69975F.

    Family and domain databases

    HAMAPiMF_00020. Acetate_kinase.
    InterProiIPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view]
    PANTHERiPTHR21060. PTHR21060. 1 hit.
    PfamiPF00871. Acetate_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSiPR00471. ACETATEKNASE.
    TIGRFAMsiTIGR00016. ackA. 1 hit.
    PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
    PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1B9S8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIAAILTLNA GSSSLKFRVF AREGLALLAR GAVSRIGADA ELVAELTGAS    50
    QVRSPVAGGD HAAAMQAVLD FIDAHDEGWR IEAVAHRIVH GGTRYTRSTP 100
    VTPQVLVDLA ALIPLAPLHQ PHGLAAIAAA RRLVGEDVPN LACFDTAFHA 150
    GRDALFTHFA LPEPLFEQGV RRYGFHGLSY QWLAQVLARD HPELHRGRVV 200
    AAHLGNGASL CAMHQGRSVD TTMGMTAVDG IPMGTRSGAV DPGAILLMQR 250
    SFGMTPEEIE DLIYNRSGLL GMSGRSNDVA ALLTDGSAQS RFALDFFALR 300
    CAQAAAAMAV SLGGIDAMVF TGGIGENAAP VREAILRHMA PLGDFATLVI 350
    PANEECMMAM EAAALLA 367
    Length:367
    Mass (Da):38,600
    Last modified:January 23, 2007 - v1
    Checksum:iD30649F83C9EAF00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000490 Genomic DNA. Translation: ABL72272.1.
    RefSeqiWP_011750437.1. NC_008687.1.
    YP_917968.1. NC_008687.1.

    Genome annotation databases

    EnsemblBacteriaiABL72272; ABL72272; Pden_4208.
    GeneIDi4582758.
    KEGGipde:Pden_4208.
    PATRICi22859604. VBIParDen97112_4155.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000490 Genomic DNA. Translation: ABL72272.1 .
    RefSeqi WP_011750437.1. NC_008687.1.
    YP_917968.1. NC_008687.1.

    3D structure databases

    ProteinModelPortali A1B9S8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318586.Pden_4208.

    Proteomic databases

    PRIDEi A1B9S8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL72272 ; ABL72272 ; Pden_4208 .
    GeneIDi 4582758.
    KEGGi pde:Pden_4208.
    PATRICi 22859604. VBIParDen97112_4155.

    Phylogenomic databases

    eggNOGi COG0282.
    HOGENOMi HOG000288399.
    KOi K00925.
    OMAi FHRGHPF.
    OrthoDBi EOG69975F.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00458 .
    BioCyci PDEN318586:GCVQ-4250-MONOMER.

    Family and domain databases

    HAMAPi MF_00020. Acetate_kinase.
    InterProi IPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR21060. PTHR21060. 1 hit.
    Pfami PF00871. Acetate_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSi PR00471. ACETATEKNASE.
    TIGRFAMsi TIGR00016. ackA. 1 hit.
    PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
    PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pd 1222Imported.

    Entry informationi

    Entry nameiA1B9S8_PARDP
    AccessioniPrimary (citable) accession number: A1B9S8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3