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A1B9S8

- A1B9S8_PARDP

UniProt

A1B9S8 - A1B9S8_PARDP

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Protein

Acetate kinase

Gene

ackA

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91MagnesiumUniRule annotation
Binding sitei16 – 161ATPUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Active sitei145 – 1451Proton donor/acceptorUniRule annotation
Sitei176 – 1761Transition state stabilizerUniRule annotation
Sitei236 – 2361Transition state stabilizerUniRule annotation
Metal bindingi354 – 3541MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi203 – 2075ATPUniRule annotation
Nucleotide bindingi323 – 3275ATPUniRule annotation

GO - Molecular functioni

  1. acetate kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. organic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-4250-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Pden_4208Imported
OrganismiParacoccus denitrificans (strain Pd 1222)Imported
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 2

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiA1B9S8.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi318586.Pden_4208.

Structurei

3D structure databases

ProteinModelPortaliA1B9S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288399.
KOiK00925.
OMAiFHRGHPF.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1B9S8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIAAILTLNA GSSSLKFRVF AREGLALLAR GAVSRIGADA ELVAELTGAS
60 70 80 90 100
QVRSPVAGGD HAAAMQAVLD FIDAHDEGWR IEAVAHRIVH GGTRYTRSTP
110 120 130 140 150
VTPQVLVDLA ALIPLAPLHQ PHGLAAIAAA RRLVGEDVPN LACFDTAFHA
160 170 180 190 200
GRDALFTHFA LPEPLFEQGV RRYGFHGLSY QWLAQVLARD HPELHRGRVV
210 220 230 240 250
AAHLGNGASL CAMHQGRSVD TTMGMTAVDG IPMGTRSGAV DPGAILLMQR
260 270 280 290 300
SFGMTPEEIE DLIYNRSGLL GMSGRSNDVA ALLTDGSAQS RFALDFFALR
310 320 330 340 350
CAQAAAAMAV SLGGIDAMVF TGGIGENAAP VREAILRHMA PLGDFATLVI
360
PANEECMMAM EAAALLA
Length:367
Mass (Da):38,600
Last modified:January 23, 2007 - v1
Checksum:iD30649F83C9EAF00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000490 Genomic DNA. Translation: ABL72272.1.
RefSeqiWP_011750437.1. NC_008687.1.
YP_917968.1. NC_008687.1.

Genome annotation databases

EnsemblBacteriaiABL72272; ABL72272; Pden_4208.
GeneIDi4582758.
KEGGipde:Pden_4208.
PATRICi22859604. VBIParDen97112_4155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000490 Genomic DNA. Translation: ABL72272.1 .
RefSeqi WP_011750437.1. NC_008687.1.
YP_917968.1. NC_008687.1.

3D structure databases

ProteinModelPortali A1B9S8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_4208.

Proteomic databases

PRIDEi A1B9S8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL72272 ; ABL72272 ; Pden_4208 .
GeneIDi 4582758.
KEGGi pde:Pden_4208.
PATRICi 22859604. VBIParDen97112_4155.

Phylogenomic databases

eggNOGi COG0282.
HOGENOMi HOG000288399.
KOi K00925.
OMAi FHRGHPF.
OrthoDBi EOG69975F.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00458 .
BioCyci PDEN318586:GCVQ-4250-MONOMER.

Family and domain databases

HAMAPi MF_00020. Acetate_kinase.
InterProi IPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view ]
PANTHERi PTHR21060. PTHR21060. 1 hit.
Pfami PF00871. Acetate_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSi PR00471. ACETATEKNASE.
TIGRFAMsi TIGR00016. ackA. 1 hit.
PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222Imported.

Entry informationi

Entry nameiA1B9S8_PARDP
AccessioniPrimary (citable) accession number: A1B9S8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3