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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciPDEN318586:G1GW1-4737-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid
Ordered Locus Names:Pden_4078
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000639231 – 446Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST446

Proteomic databases

PRIDEiA1B9F0

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_4078

Structurei

3D structure databases

ProteinModelPortaliA1B9F0
SMRiA1B9F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP
OrthoDBiPOG091H00B3

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit
PROSITEiView protein in PROSITE
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1B9F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPIHIIGAG LAGSEAAWQI ARAGVPVVLH EMRPQVATFA HRTGDCAEMV
60 70 80 90 100
CSNSFRSDDD RMNAVGQLHW EMRAAGGLIM AMADRHRLPA GGALAVDRDA
110 120 130 140 150
FSQAVTQALQ AEPLVSFQPG EISDLPSEGH WIVATGPLTS EALGRSIRSL
160 170 180 190 200
TGEGSLAFFD AIAPIVHAES IDMSICWRQS RYDKGETEEE RTAYINCPMT
210 220 230 240 250
REDYEGFIDA LLAADKTEFH EGETAGYFDG CLPIEVMAER GRETLRHGPM
260 270 280 290 300
KPVGLTNAHN PAEKPYAVVQ LRRDNALGTL YNIVGFQTKM KYGAQVDVFR
310 320 330 340 350
RIPGLQDASF ARLGGIHRNT FLNSPRLIDD RLRLRARPHL RFAGQVTGVE
360 370 380 390 400
GYVESAAMGL LAGRMAAAEA LGRDLPPPPA TTSMGALVSH ITGGADAKTF
410 420 430 440
QPMNVNFGLY PPLDAMRGGR KGRKDRYPAY TDRAKADFQQ WVAGES
Length:446
Mass (Da):48,562
Last modified:January 23, 2007 - v1
Checksum:i6AFDBAA9E2D8B7DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000490 Genomic DNA Translation: ABL72144.1
RefSeqiWP_011750312.1, NC_008687.1

Genome annotation databases

EnsemblBacteriaiABL72144; ABL72144; Pden_4078
KEGGipde:Pden_4078

Entry informationi

Entry nameiTRMFO_PARDP
AccessioniPrimary (citable) accession number: A1B9F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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