Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1B5Q5

- SYL_PARDP

UniProt

A1B5Q5 - SYL_PARDP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei624 – 6241ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2806-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pden_2765
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 844844Leucine--tRNA ligasePRO_0000334787Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_2765.

Structurei

3D structure databases

ProteinModelPortaliA1B5Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 4911"HIGH" regionAdd
BLAST
Motifi621 – 6255"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1B5Q5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYDPAISEP RWQEAWEQAD TFRAVRDERP KYYVLEMFPY PSGRIHMGHV
60 70 80 90 100
RNYTMGDVVA RFKRAQGFSV LHPMGWDAFG MPAENAAMEQ GGHPRDWTYG
110 120 130 140 150
NIATMRGQLK PLGLSIDWSR EFATCDDAYV AQQQALFLDM LEAGLITRKS
160 170 180 190 200
AQVNWDPVDM TVLANEQVID GKGWRSGATV ERKELTQWFF KISDYSDELL
210 220 230 240 250
SALDGLEGWP EKVRLMQANW IGKSRGLQFR FHTVDLPDFP TIEVYTTRPD
260 270 280 290 300
TLMGASFVAL SPDHPLVKAL AASDPKVAAF VEECRRIGTT EEAIETAPKM
310 320 330 340 350
GFDTGLTVRH PLDADWRLPI WIANFVLMDY GTGAIFGSPA HDERDHEFAT
360 370 380 390 400
KYGLPIRATF GERGMDLEQA DALVAKAPFV PLKSETVTYV RGFAGAADQT
410 420 430 440 450
GEAAVDAAIR HAEVAGYGEG VTKFRLRDWG ISRQRYWGCP IPVVHCDACG
460 470 480 490 500
TVPEAKANLP VLLPQDVSFE VPGNPLNRHP TWAATTCPKC GGPARRETDT
510 520 530 540 550
MDTFVDSSWY YARFTSPHAA TPTDRPETDY WMNVDQYIGG IEHAILHLLY
560 570 580 590 600
SRFFARAMVK TGHLPESAKE PFDALFTQGM VTHEIYMTRD ERGRPVYHLP
610 620 630 640 650
EDVVDGKLAD GTPVEVIPSA KMSKSKKNVV DPVNIVEGFG ADTARWFMLS
660 670 680 690 700
DSPPERDVEW TAAGAEAANR FLARVWRLAD EIPEDGADPD LTRAAHRAID
710 720 730 740 750
EVTRAIEGFA FNKAVAKIYE LANAIAKSGA GGESRREALR IMAQLMAPMV
760 770 780 790 800
PHLAEEIWMK AGGQGMVVDA TWPKADPALL VSDSVVLPIQ INGKRRAEIE
810 820 830 840
VPKDMPKDQI EAIVLADETV RRFMEGQAPK KLIVVPGRIV NVVV
Length:844
Mass (Da):93,879
Last modified:January 23, 2007 - v1
Checksum:i1DE1B82D42F62E75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70849.1.
RefSeqiWP_011749040.1. NC_008686.1.
YP_916545.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70849; ABL70849; Pden_2765.
GeneIDi4581344.
KEGGipde:Pden_2765.
PATRICi22856677. VBIParDen97112_2704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70849.1 .
RefSeqi WP_011749040.1. NC_008686.1.
YP_916545.1. NC_008686.1.

3D structure databases

ProteinModelPortali A1B5Q5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_2765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL70849 ; ABL70849 ; Pden_2765 .
GeneIDi 4581344.
KEGGi pde:Pden_2765.
PATRICi 22856677. VBIParDen97112_2704.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PDEN318586:GCVQ-2806-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiSYL_PARDP
AccessioniPrimary (citable) accession number: A1B5Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3