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A1B5Q5

- SYL_PARDP

UniProt

A1B5Q5 - SYL_PARDP

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Protein
Leucine--tRNA ligase
Gene
leuS, Pden_2765
Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei624 – 6241ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2806-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Pden_2765
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 844844Leucine--tRNA ligaseUniRule annotation
PRO_0000334787Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_2765.

Structurei

3D structure databases

ProteinModelPortaliA1B5Q5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 4911"HIGH" regionUniRule annotation
Add
BLAST
Motifi621 – 6255"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1B5Q5-1 [UniParc]FASTAAdd to Basket

« Hide

MPYDPAISEP RWQEAWEQAD TFRAVRDERP KYYVLEMFPY PSGRIHMGHV    50
RNYTMGDVVA RFKRAQGFSV LHPMGWDAFG MPAENAAMEQ GGHPRDWTYG 100
NIATMRGQLK PLGLSIDWSR EFATCDDAYV AQQQALFLDM LEAGLITRKS 150
AQVNWDPVDM TVLANEQVID GKGWRSGATV ERKELTQWFF KISDYSDELL 200
SALDGLEGWP EKVRLMQANW IGKSRGLQFR FHTVDLPDFP TIEVYTTRPD 250
TLMGASFVAL SPDHPLVKAL AASDPKVAAF VEECRRIGTT EEAIETAPKM 300
GFDTGLTVRH PLDADWRLPI WIANFVLMDY GTGAIFGSPA HDERDHEFAT 350
KYGLPIRATF GERGMDLEQA DALVAKAPFV PLKSETVTYV RGFAGAADQT 400
GEAAVDAAIR HAEVAGYGEG VTKFRLRDWG ISRQRYWGCP IPVVHCDACG 450
TVPEAKANLP VLLPQDVSFE VPGNPLNRHP TWAATTCPKC GGPARRETDT 500
MDTFVDSSWY YARFTSPHAA TPTDRPETDY WMNVDQYIGG IEHAILHLLY 550
SRFFARAMVK TGHLPESAKE PFDALFTQGM VTHEIYMTRD ERGRPVYHLP 600
EDVVDGKLAD GTPVEVIPSA KMSKSKKNVV DPVNIVEGFG ADTARWFMLS 650
DSPPERDVEW TAAGAEAANR FLARVWRLAD EIPEDGADPD LTRAAHRAID 700
EVTRAIEGFA FNKAVAKIYE LANAIAKSGA GGESRREALR IMAQLMAPMV 750
PHLAEEIWMK AGGQGMVVDA TWPKADPALL VSDSVVLPIQ INGKRRAEIE 800
VPKDMPKDQI EAIVLADETV RRFMEGQAPK KLIVVPGRIV NVVV 844
Length:844
Mass (Da):93,879
Last modified:January 23, 2007 - v1
Checksum:i1DE1B82D42F62E75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70849.1.
RefSeqiWP_011749040.1. NC_008686.1.
YP_916545.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70849; ABL70849; Pden_2765.
GeneIDi4581344.
KEGGipde:Pden_2765.
PATRICi22856677. VBIParDen97112_2704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70849.1 .
RefSeqi WP_011749040.1. NC_008686.1.
YP_916545.1. NC_008686.1.

3D structure databases

ProteinModelPortali A1B5Q5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_2765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL70849 ; ABL70849 ; Pden_2765 .
GeneIDi 4581344.
KEGGi pde:Pden_2765.
PATRICi 22856677. VBIParDen97112_2704.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PDEN318586:GCVQ-2806-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiSYL_PARDP
AccessioniPrimary (citable) accession number: A1B5Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi