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A1B5Q5 (SYL_PARDP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Pden_2765
OrganismParacoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP]
Taxonomic identifier318586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length844 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 844844Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334787

Regions

Motif39 – 4911"HIGH" region HAMAP-Rule MF_00049
Motif621 – 6255"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6241ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1B5Q5 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 1DE1B82D42F62E75

FASTA84493,879
        10         20         30         40         50         60 
MPYDPAISEP RWQEAWEQAD TFRAVRDERP KYYVLEMFPY PSGRIHMGHV RNYTMGDVVA 

        70         80         90        100        110        120 
RFKRAQGFSV LHPMGWDAFG MPAENAAMEQ GGHPRDWTYG NIATMRGQLK PLGLSIDWSR 

       130        140        150        160        170        180 
EFATCDDAYV AQQQALFLDM LEAGLITRKS AQVNWDPVDM TVLANEQVID GKGWRSGATV 

       190        200        210        220        230        240 
ERKELTQWFF KISDYSDELL SALDGLEGWP EKVRLMQANW IGKSRGLQFR FHTVDLPDFP 

       250        260        270        280        290        300 
TIEVYTTRPD TLMGASFVAL SPDHPLVKAL AASDPKVAAF VEECRRIGTT EEAIETAPKM 

       310        320        330        340        350        360 
GFDTGLTVRH PLDADWRLPI WIANFVLMDY GTGAIFGSPA HDERDHEFAT KYGLPIRATF 

       370        380        390        400        410        420 
GERGMDLEQA DALVAKAPFV PLKSETVTYV RGFAGAADQT GEAAVDAAIR HAEVAGYGEG 

       430        440        450        460        470        480 
VTKFRLRDWG ISRQRYWGCP IPVVHCDACG TVPEAKANLP VLLPQDVSFE VPGNPLNRHP 

       490        500        510        520        530        540 
TWAATTCPKC GGPARRETDT MDTFVDSSWY YARFTSPHAA TPTDRPETDY WMNVDQYIGG 

       550        560        570        580        590        600 
IEHAILHLLY SRFFARAMVK TGHLPESAKE PFDALFTQGM VTHEIYMTRD ERGRPVYHLP 

       610        620        630        640        650        660 
EDVVDGKLAD GTPVEVIPSA KMSKSKKNVV DPVNIVEGFG ADTARWFMLS DSPPERDVEW 

       670        680        690        700        710        720 
TAAGAEAANR FLARVWRLAD EIPEDGADPD LTRAAHRAID EVTRAIEGFA FNKAVAKIYE 

       730        740        750        760        770        780 
LANAIAKSGA GGESRREALR IMAQLMAPMV PHLAEEIWMK AGGQGMVVDA TWPKADPALL 

       790        800        810        820        830        840 
VSDSVVLPIQ INGKRRAEIE VPKDMPKDQI EAIVLADETV RRFMEGQAPK KLIVVPGRIV 


NVVV 

« Hide

References

[1]"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pd 1222.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000489 Genomic DNA. Translation: ABL70849.1.
RefSeqYP_916545.1. NC_008686.1.

3D structure databases

ProteinModelPortalA1B5Q5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING318586.Pden_2765.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL70849; ABL70849; Pden_2765.
GeneID4581344.
KEGGpde:Pden_2765.
PATRIC22856677. VBIParDen97112_2704.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAVVHCDAC.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycPDEN318586:GCVQ-2806-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PARDP
AccessionPrimary (citable) accession number: A1B5Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries