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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei624ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDEN318586:G1GW1-2797-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pden_2765
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347871 – 844Leucine--tRNA ligaseAdd BLAST844

Proteomic databases

PRIDEiA1B5Q5

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_2765

Structurei

3D structure databases

ProteinModelPortaliA1B5Q5
SMRiA1B5Q5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi39 – 49"HIGH" regionAdd BLAST11
Motifi621 – 625"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1B5Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYDPAISEP RWQEAWEQAD TFRAVRDERP KYYVLEMFPY PSGRIHMGHV
60 70 80 90 100
RNYTMGDVVA RFKRAQGFSV LHPMGWDAFG MPAENAAMEQ GGHPRDWTYG
110 120 130 140 150
NIATMRGQLK PLGLSIDWSR EFATCDDAYV AQQQALFLDM LEAGLITRKS
160 170 180 190 200
AQVNWDPVDM TVLANEQVID GKGWRSGATV ERKELTQWFF KISDYSDELL
210 220 230 240 250
SALDGLEGWP EKVRLMQANW IGKSRGLQFR FHTVDLPDFP TIEVYTTRPD
260 270 280 290 300
TLMGASFVAL SPDHPLVKAL AASDPKVAAF VEECRRIGTT EEAIETAPKM
310 320 330 340 350
GFDTGLTVRH PLDADWRLPI WIANFVLMDY GTGAIFGSPA HDERDHEFAT
360 370 380 390 400
KYGLPIRATF GERGMDLEQA DALVAKAPFV PLKSETVTYV RGFAGAADQT
410 420 430 440 450
GEAAVDAAIR HAEVAGYGEG VTKFRLRDWG ISRQRYWGCP IPVVHCDACG
460 470 480 490 500
TVPEAKANLP VLLPQDVSFE VPGNPLNRHP TWAATTCPKC GGPARRETDT
510 520 530 540 550
MDTFVDSSWY YARFTSPHAA TPTDRPETDY WMNVDQYIGG IEHAILHLLY
560 570 580 590 600
SRFFARAMVK TGHLPESAKE PFDALFTQGM VTHEIYMTRD ERGRPVYHLP
610 620 630 640 650
EDVVDGKLAD GTPVEVIPSA KMSKSKKNVV DPVNIVEGFG ADTARWFMLS
660 670 680 690 700
DSPPERDVEW TAAGAEAANR FLARVWRLAD EIPEDGADPD LTRAAHRAID
710 720 730 740 750
EVTRAIEGFA FNKAVAKIYE LANAIAKSGA GGESRREALR IMAQLMAPMV
760 770 780 790 800
PHLAEEIWMK AGGQGMVVDA TWPKADPALL VSDSVVLPIQ INGKRRAEIE
810 820 830 840
VPKDMPKDQI EAIVLADETV RRFMEGQAPK KLIVVPGRIV NVVV
Length:844
Mass (Da):93,879
Last modified:January 23, 2007 - v1
Checksum:i1DE1B82D42F62E75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA Translation: ABL70849.1
RefSeqiWP_011749040.1, NC_008686.1

Genome annotation databases

EnsemblBacteriaiABL70849; ABL70849; Pden_2765
KEGGipde:Pden_2765

Similar proteinsi

Entry informationi

Entry nameiSYL_PARDP
AccessioniPrimary (citable) accession number: A1B5Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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