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A1B5K8

- PUR9_PARDP

UniProt

A1B5K8 - PUR9_PARDP

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciPDEN318586:GCVQ-2759-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Pden_2718
    OrganismiParacoccus denitrificans (strain Pd 1222)
    Taxonomic identifieri318586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
    ProteomesiUP000000361: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000057901Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi318586.Pden_2718.

    Structurei

    3D structure databases

    ProteinModelPortaliA1B5K8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiYRRECED.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1B5K8-1 [UniParc]FASTAAdd to Basket

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    MTDRIPLKRA LISVSDKTGL VDFARALSAR GVEILSTGGT AKTLREAGLS    50
    VVDVADVTGF PEMMDGRVKT LHPVVHGGLL ALRDNDEHMA AAKSHRIGMI 100
    DLLVVNLYPF EATVAKGAAY DDCIENIDIG GPAMIRAAAK NHAFVTVVVD 150
    VQDYAAVLAE LDANDDRTGL AFRQRQAQIA YARTAAYDAA VSTWMAGAIG 200
    EETPRRRSFS GQLAQSLRYG ENPHQSAAFY RDGSDRPGVA TARQWQGKEL 250
    SYNNINDTDA AFELVAEFDP AEGPAVAIIK HANPCGVARG DSAVDAYLRA 300
    FDCDRTSAFG GIIALNTTLD GETAQAITEI FTEVVIAPDA TDEAKEIFAA 350
    KKNLRLLTTG GLPDPAAPGL AFRQVAGGFL VQGRDNGRIL RADLKVVTKR 400
    QPTDQELADL LFAWTVAKHV KSNAIVYARD LATVGIGAGQ MSRVDSTRIG 450
    KRKSEDMAEA LGLAQALTIG SSVASDAFFP FADGVEALAA AGARAVIQPG 500
    GSMRDAEVIE AADRLGLAMV FTGQRHFRH 529
    Length:529
    Mass (Da):56,268
    Last modified:January 23, 2007 - v1
    Checksum:i5A8224550D6D4B2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000489 Genomic DNA. Translation: ABL70802.1.
    RefSeqiWP_011748993.1. NC_008686.1.
    YP_916498.1. NC_008686.1.

    Genome annotation databases

    EnsemblBacteriaiABL70802; ABL70802; Pden_2718.
    GeneIDi4580353.
    KEGGipde:Pden_2718.
    PATRICi22856577. VBIParDen97112_2654.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000489 Genomic DNA. Translation: ABL70802.1 .
    RefSeqi WP_011748993.1. NC_008686.1.
    YP_916498.1. NC_008686.1.

    3D structure databases

    ProteinModelPortali A1B5K8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318586.Pden_2718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL70802 ; ABL70802 ; Pden_2718 .
    GeneIDi 4580353.
    KEGGi pde:Pden_2718.
    PATRICi 22856577. VBIParDen97112_2654.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi YRRECED.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci PDEN318586:GCVQ-2759-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pd 1222.

    Entry informationi

    Entry nameiPUR9_PARDP
    AccessioniPrimary (citable) accession number: A1B5K8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3