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A1B5A7 (FOLD1_PARDP) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein FolD 1

Including the following 2 domains:

  1. Methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.5
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:folD1
Ordered Locus Names:Pden_2614
OrganismParacoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP]
Taxonomic identifier318586 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP MF_01576

Catalytic activity

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01576

Subunit structure

Homodimer By similarity. HAMAP MF_01576

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Bifunctional protein FolD 1 HAMAP MF_01576
PRO_0000340585

Sequences

Sequence LengthMass (Da)Tools
A1B5A7 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 27F32F0674A887EC

FASTA29830,802
        10         20         30         40         50         60 
MVARIIDGKA FASGVRGRVA SAVAGLEAAH GVVPGLAVVL VGEDPASQVY VRNKGIQTRE 

        70         80         90        100        110        120 
AGMASFEHKL PAETAQAELM ALIERLNADP AVHGILVQLP LPRHMDAEAV INAIDPKKDV 

       130        140        150        160        170        180 
DGFHVLNVGL LGTGQKAMVP CTPLGCLMLL RDTLGDLSGL NAVVVGRSNI VGKPMAQLLL 

       190        200        210        220        230        240 
NESCTVTIAH SRTRDLAGLC RTADILVAAV GRPRMIRGDW IKPGATVIDV GINRIEEAGR 

       250        260        270        280        290 
SRLVGDVDFD SAAPVAGAIT PVPGGVGPMT IACLLANTLT ACCRANGLPE PDFAEAGG

« Hide

References

[1]"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pd 1222.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000489 Genomic DNA. Translation: ABL70701.1.
RefSeqYP_916397.1. NC_008686.1.

3D structure databases

ProteinModelPortalA1B5A7.
SMRA1B5A7. Positions 3-287.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1B5A7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4580713.
GenomeReviewsGene locus Pden_2614 in contig CP000489_GR.
KEGGpde:Pden_2614.
PATRIC22856361. VBIParDen97112_2545.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0190.
HOGENOMHBG328751.
OMANQDERVD.
PhylomeDBA1B5A7.
ProtClustDBPRK14188.

Family and domain databases

HAMAPMF_01576. THF_DHG_CYH.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01491.
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD1_PARDP
AccessionPrimary (citable) accession number: A1B5A7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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