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A1B587

- IF2_PARDP

UniProt

A1B587 - IF2_PARDP

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Protein
Translation initiation factor IF-2
Gene
infB, Pden_2594
Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi355 – 3628GTP By similarity
Nucleotide bindingi402 – 4065GTP By similarity
Nucleotide bindingi456 – 4594GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2635-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:Pden_2594
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 848848Translation initiation factor IF-2UniRule annotation
PRO_1000008293Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_2594.

Structurei

3D structure databases

ProteinModelPortaliA1B587.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini346 – 514169tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni355 – 3628G1 By similarity
Regioni380 – 3845G2 By similarity
Regioni402 – 4054G3 By similarity
Regioni456 – 4594G4 By similarity
Regioni492 – 4943G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiESINHVK.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1B587-1 [UniParc]FASTAAdd to Basket

« Hide

MSDTDGKKPL GLGGGRSGHV KQSFSHGRTH NVVVETKRKR VVVPGKTGAA    50
AGGGRSGSPS AVSGDPSKRP AGISDAEMER RMAALRAAKA REVEEAAQRI 100
ADEKAREEER ERRRLELEAK EREEREREEA LRLKAEEDER RAREAELREK 150
KKAEIAKPKT EARPATPADR AAAEAAAVRA ETKGVSAAGP RKTDRDRDTR 200
GGGGDDRDSR NKGRDDSRRT GKLSLSQALD GEGGRQRSLA AMKRKQEKAR 250
QKAMGGNQRA EKQVRDVQLP ETIVVSELAN RMAERTPDVI KSLMRMGMMV 300
TANQSIDADT AELVIDEFGH HAVRVSDADV EQVIDQVEDK PEDLQPRAPI 350
ITIMGHVDHG KTSLLDAIRH ANVVAGEAGG ITQHIGAYQV KASNGAVLTF 400
LDTPGHAAFT SMRARGAQVT DIVVLVVAAD DAVMPQTVEA INHAKAAKVP 450
MIVAINKIDK PAANPQKVRT DLLLHEVVVE AMSGEVQDVE VSAKTGQGLD 500
TLLEAIALQA EILELKANPD RPAQGAVIEA QLDVGRGPVA TVLVQNGTLK 550
RGDIFVVGEQ WGKVRALIND KGERVDEAGP SVPVEVLGLN GTPEAGDVLN 600
VVSTEAQARE IADYRIQAAK DKRAAAGAAI TLDQMLAKAK ADENVAELPV 650
VIKADVQGSA EAIVQALEKI GNDEVRVRVL HYGVGAITES DIGLAEASQA 700
PVIGFNVRAN APARNAANQK GVEIRYYSII YDLVDDIKAA ASGLLSAEVR 750
ENFIGYAEIK EVFRVSGVGN VAGCLVTEGV ARRSAGVRLL RDNVVIHEGT 800
LKTLKRFKDE VKEVQSGQEC GMAFENYDDI RKGDVIEIFE REEVQRQL 848
Length:848
Mass (Da):91,294
Last modified:January 23, 2007 - v1
Checksum:iB7DB50802DADE02D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70681.1.
RefSeqiYP_916377.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70681; ABL70681; Pden_2594.
GeneIDi4580693.
KEGGipde:Pden_2594.
PATRICi22856319. VBIParDen97112_2524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70681.1 .
RefSeqi YP_916377.1. NC_008686.1.

3D structure databases

ProteinModelPortali A1B587.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_2594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL70681 ; ABL70681 ; Pden_2594 .
GeneIDi 4580693.
KEGGi pde:Pden_2594.
PATRICi 22856319. VBIParDen97112_2524.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi ESINHVK.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci PDEN318586:GCVQ-2635-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiIF2_PARDP
AccessioniPrimary (citable) accession number: A1B587
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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