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A1B587 (IF2_PARDP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:Pden_2594
OrganismParacoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP]
Taxonomic identifier318586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length848 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 848848Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000008293

Regions

Nucleotide binding355 – 3628GTP By similarity
Nucleotide binding402 – 4065GTP By similarity
Nucleotide binding456 – 4594GTP By similarity
Region349 – 498150G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
A1B587 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: B7DB50802DADE02D

FASTA84891,294
        10         20         30         40         50         60 
MSDTDGKKPL GLGGGRSGHV KQSFSHGRTH NVVVETKRKR VVVPGKTGAA AGGGRSGSPS 

        70         80         90        100        110        120 
AVSGDPSKRP AGISDAEMER RMAALRAAKA REVEEAAQRI ADEKAREEER ERRRLELEAK 

       130        140        150        160        170        180 
EREEREREEA LRLKAEEDER RAREAELREK KKAEIAKPKT EARPATPADR AAAEAAAVRA 

       190        200        210        220        230        240 
ETKGVSAAGP RKTDRDRDTR GGGGDDRDSR NKGRDDSRRT GKLSLSQALD GEGGRQRSLA 

       250        260        270        280        290        300 
AMKRKQEKAR QKAMGGNQRA EKQVRDVQLP ETIVVSELAN RMAERTPDVI KSLMRMGMMV 

       310        320        330        340        350        360 
TANQSIDADT AELVIDEFGH HAVRVSDADV EQVIDQVEDK PEDLQPRAPI ITIMGHVDHG 

       370        380        390        400        410        420 
KTSLLDAIRH ANVVAGEAGG ITQHIGAYQV KASNGAVLTF LDTPGHAAFT SMRARGAQVT 

       430        440        450        460        470        480 
DIVVLVVAAD DAVMPQTVEA INHAKAAKVP MIVAINKIDK PAANPQKVRT DLLLHEVVVE 

       490        500        510        520        530        540 
AMSGEVQDVE VSAKTGQGLD TLLEAIALQA EILELKANPD RPAQGAVIEA QLDVGRGPVA 

       550        560        570        580        590        600 
TVLVQNGTLK RGDIFVVGEQ WGKVRALIND KGERVDEAGP SVPVEVLGLN GTPEAGDVLN 

       610        620        630        640        650        660 
VVSTEAQARE IADYRIQAAK DKRAAAGAAI TLDQMLAKAK ADENVAELPV VIKADVQGSA 

       670        680        690        700        710        720 
EAIVQALEKI GNDEVRVRVL HYGVGAITES DIGLAEASQA PVIGFNVRAN APARNAANQK 

       730        740        750        760        770        780 
GVEIRYYSII YDLVDDIKAA ASGLLSAEVR ENFIGYAEIK EVFRVSGVGN VAGCLVTEGV 

       790        800        810        820        830        840 
ARRSAGVRLL RDNVVIHEGT LKTLKRFKDE VKEVQSGQEC GMAFENYDDI RKGDVIEIFE 


REEVQRQL 

« Hide

References

[1]"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pd 1222.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000489 Genomic DNA. Translation: ABL70681.1.
RefSeqYP_916377.1. NC_008686.1.

3D structure databases

ProteinModelPortalA1B587.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING318586.Pden_2594.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL70681; ABL70681; Pden_2594.
GeneID4580693.
KEGGpde:Pden_2594.
PATRIC22856319. VBIParDen97112_2524.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076907.
KOK02519.
OMAESINHVK.
OrthoDBEOG67HJSV.

Enzyme and pathway databases

BioCycPDEN318586:GCVQ-2635-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_PARDP
AccessionPrimary (citable) accession number: A1B587
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries