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Protein

Catalase-peroxidase

Gene

katG

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei95 – 951Transition state stabilizerUniRule annotation
Active sitei99 – 991Proton acceptorUniRule annotation
Metal bindingi267 – 2671Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2538-MONOMER.

Protein family/group databases

PeroxiBasei3626. PdeCP01_PD1222.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Pden_2497
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Catalase-peroxidasePRO_0000354853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki98 ↔ 226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)UniRule annotation
Cross-linki226 ↔ 252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA1B4Z0.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi318586.Pden_2497.

Structurei

3D structure databases

ProteinModelPortaliA1B4Z0.
SMRiA1B4Z0. Positions 25-723.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1B4Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGNDIRSTG KCPVMHGGNT AMGSSVTAWW PNALNLDILH QHDSKTNPLG
60 70 80 90 100
QDFNYSEELK KLDVEALKAD LRALMTDSQD WWPADWGSYV GMFARTAWHM
110 120 130 140 150
AGSYRTSDGR GGANTGNQRF APLNSWPDNV NTDKGRRLLW PIKKKYGNKI
160 170 180 190 200
SWADLIVLAG TVAYEAAGLK TYGFAFGRED IWHPEKDTYW GEEKEWLAPS
210 220 230 240 250
DSRYGDVTKA ETLANPLAAV QMGLIYVNPE GVNGKSDPQA TAYQMRETFA
260 270 280 290 300
RMGMNDEETV ALTAGGHTVG KCHGNGNVTD LSPDPEAAGP EFQGLGWMNT
310 320 330 340 350
KGRGIGRNTM VSGLEGAWTT HPTQWDNGFF EMLFKHEWTL THSPAGASQW
360 370 380 390 400
EPITIAEEDK PADVEDPSIR HMPMMTDADM ALKVDPIYRE ISLRFMNDFE
410 420 430 440 450
AFSDAFARAW FKLTHRDMGP KARYLGPDVP AEDLVWQDPI PAGRSDYDVA
460 470 480 490 500
AVKARIAASG LSASDLVATA WDSARTYRGS DHRGGANGAR IRLAPQKDWE
510 520 530 540 550
GNEPQRLARV LSVLEPIAAE TGASLADVIV LGGNLGVEQA AKAAGFDIEV
560 570 580 590 600
PFAPGRGDST AEQTDAASFD VLEPLADGFR NWQKQDYVVS PEEMLLDRAQ
610 620 630 640 650
LMGLTAPEMT TLIGGLRVIG TNHGGTKHGV FTQRKGALTN DFFVTLTDMA
660 670 680 690 700
NNWVPVGNNL YEIRDRKTGA TRYTATRVDL VFGSNSILRA YAEVYAQDDN
710 720
AGKFVRDFVA AWTKVMNADR FDLAA
Length:725
Mass (Da):79,623
Last modified:January 23, 2007 - v1
Checksum:i52AFEBBE3A3857B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA. Translation: ABL70584.1.
RefSeqiWP_011748777.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70584; ABL70584; Pden_2497.
KEGGipde:Pden_2497.
PATRICi22856117. VBIParDen97112_2423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA. Translation: ABL70584.1.
RefSeqiWP_011748777.1. NC_008686.1.

3D structure databases

ProteinModelPortaliA1B4Z0.
SMRiA1B4Z0. Positions 25-723.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318586.Pden_2497.

Protein family/group databases

PeroxiBasei3626. PdeCP01_PD1222.

Proteomic databases

PRIDEiA1B4Z0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL70584; ABL70584; Pden_2497.
KEGGipde:Pden_2497.
PATRICi22856117. VBIParDen97112_2423.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2538-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_PARDP
AccessioniPrimary (citable) accession number: A1B4Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.