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A1B479

- NUON_PARDP

UniProt

A1B479 - NUON_PARDP

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Protein

NADH-quinone oxidoreductase subunit N

Gene
nuoN, nqo14, Pden_2231
Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit N (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit 14
NADH dehydrogenase I subunit N
NADH-quinone oxidoreductase subunit 14
Short name:
NQO14
NDH-1 subunit 14
NDH-1 subunit N
Gene namesi
Name:nuoN
Synonyms:nqo14
Ordered Locus Names:Pden_2231
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

Subcellular locationi

Cell inner membrane; Multi-pass membrane protein Inferred 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Reviewed predictionAdd
BLAST
Transmembranei37 – 5721Helical; Reviewed predictionAdd
BLAST
Transmembranei76 – 9621Helical; Reviewed predictionAdd
BLAST
Transmembranei104 – 12421Helical; Reviewed predictionAdd
BLAST
Transmembranei126 – 14621Helical; Reviewed predictionAdd
BLAST
Transmembranei161 – 18121Helical; Reviewed predictionAdd
BLAST
Transmembranei196 – 21621Helical; Reviewed predictionAdd
BLAST
Transmembranei235 – 25521Helical; Reviewed predictionAdd
BLAST
Transmembranei269 – 28921Helical; Reviewed predictionAdd
BLAST
Transmembranei301 – 32121Helical; Reviewed predictionAdd
BLAST
Transmembranei324 – 34421Helical; Reviewed predictionAdd
BLAST
Transmembranei369 – 38921Helical; Reviewed predictionAdd
BLAST
Transmembranei402 – 42221Helical; Reviewed predictionAdd
BLAST
Transmembranei446 – 46621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499NADH-quinone oxidoreductase subunit NUniRule annotationPRO_0000391197Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of at least 14 different subunits, nqo1 to nqo14. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8, nqo10 to nqo14) embedded in the inner membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers By similarity. NADH-quinone oxidoreductase forms a supercomplex with ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) and cytochrome c oxidase (complex IV), which stabilizes the NADH-quinone oxidoreductase complex.1 Publication

Protein-protein interaction databases

STRINGi318586.Pden_2231.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100795.
KOiK00343.
OMAiIDKLSWI.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A1B479-1 [UniParc]FASTAAdd to Basket

« Hide

MTSLDFSTIL PEVVLAGYAL AALMAGAYLG KDRLARTLLW VTVAAFLVVA    50
AMVGLGNHVD GAAFHGMFID DGFSRFAKVV TLVAAAGVLA MSADYMQRRN 100
MLRFEFPIIV ALAVLGMMFM VSAGDLLTLY MGLELQSLAL YVVAAMRRDS 150
VRSSEAGLKY FVLGSLSSGL LLYGASLVYG FAGTTGFEGI ISTIEAGHLS 200
LGVLFGLVFM LVGLSFKVSA VPFHMWTPDV YEGSPTPVTA FFATAPKVAA 250
MALIARLVFD AFGHVIGDWS QIVAALAVMS MFLGSIAGIG QTNIKRLMAY 300
SSIAHMGFAL VGLAAGTAIG VQNMLLYMTI YAVMNIGTFA FILSMERDGV 350
PVTDLAALNR FAWTDPVKAL AMLVLMFSLA GVPPTLGFFA KFGVLTAAVD 400
AGMGWLAVLG VIASVIGAFY YLRIVYYMYF GGESEGMTSR MGAVQYLALM 450
VPALAMLVGA ISMFGVDSAA GRAAETLVGP VAAIEQPAEA AQAEPVQGE 499
Length:499
Mass (Da):52,535
Last modified:January 23, 2007 - v1
Checksum:iF116A0CEA09ED72A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70323.1.
RefSeqiWP_011748518.1. NC_008686.1.
YP_916019.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70323; ABL70323; Pden_2231.
GeneIDi4579285.
KEGGipde:Pden_2231.
PATRICi22855587. VBIParDen97112_2162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70323.1 .
RefSeqi WP_011748518.1. NC_008686.1.
YP_916019.1. NC_008686.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_2231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL70323 ; ABL70323 ; Pden_2231 .
GeneIDi 4579285.
KEGGi pde:Pden_2231.
PATRICi 22855587. VBIParDen97112_2162.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100795.
KOi K00343.
OMAi IDKLSWI.
OrthoDBi EOG64JFNZ.

Enzyme and pathway databases

BioCyci PDEN318586:GCVQ-2271-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.
  2. "Assembly of respiratory complexes I, III, and IV into NADH oxidase supercomplex stabilizes complex I in Paracoccus denitrificans."
    Stroh A., Anderka O., Pfeiffer K., Yagi T., Finel M., Ludwig B., Schagger H.
    J. Biol. Chem. 279:5000-5007(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN NADH OXIDASE SUPERCOMPLEX, SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNUON_PARDP
AccessioniPrimary (citable) accession number: A1B479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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