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A1B479

- NUON_PARDP

UniProt

A1B479 - NUON_PARDP

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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.By similarity

Catalytic activityi

NADH + quinone = NAD+ + quinol.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit N (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit 14
NADH dehydrogenase I subunit N
NADH-quinone oxidoreductase subunit 14
Short name:
NQO14
NDH-1 subunit 14
NDH-1 subunit N
Gene namesi
Name:nuoN
Synonyms:nqo14
Ordered Locus Names:Pden_2231
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

Subcellular locationi

Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499NADH-quinone oxidoreductase subunit NPRO_0000391197Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of at least 14 different subunits, nqo1 to nqo14. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8, nqo10 to nqo14) embedded in the inner membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers By similarity. NADH-quinone oxidoreductase forms a supercomplex with ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) and cytochrome c oxidase (complex IV), which stabilizes the NADH-quinone oxidoreductase complex.By similarity1 Publication

Protein-protein interaction databases

STRINGi318586.Pden_2231.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence AnalysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence AnalysisAdd
BLAST
Transmembranei369 – 38921HelicalSequence AnalysisAdd
BLAST
Transmembranei402 – 42221HelicalSequence AnalysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100795.
KOiK00343.
OMAiIDKLSWI.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A1B479-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSLDFSTIL PEVVLAGYAL AALMAGAYLG KDRLARTLLW VTVAAFLVVA
60 70 80 90 100
AMVGLGNHVD GAAFHGMFID DGFSRFAKVV TLVAAAGVLA MSADYMQRRN
110 120 130 140 150
MLRFEFPIIV ALAVLGMMFM VSAGDLLTLY MGLELQSLAL YVVAAMRRDS
160 170 180 190 200
VRSSEAGLKY FVLGSLSSGL LLYGASLVYG FAGTTGFEGI ISTIEAGHLS
210 220 230 240 250
LGVLFGLVFM LVGLSFKVSA VPFHMWTPDV YEGSPTPVTA FFATAPKVAA
260 270 280 290 300
MALIARLVFD AFGHVIGDWS QIVAALAVMS MFLGSIAGIG QTNIKRLMAY
310 320 330 340 350
SSIAHMGFAL VGLAAGTAIG VQNMLLYMTI YAVMNIGTFA FILSMERDGV
360 370 380 390 400
PVTDLAALNR FAWTDPVKAL AMLVLMFSLA GVPPTLGFFA KFGVLTAAVD
410 420 430 440 450
AGMGWLAVLG VIASVIGAFY YLRIVYYMYF GGESEGMTSR MGAVQYLALM
460 470 480 490
VPALAMLVGA ISMFGVDSAA GRAAETLVGP VAAIEQPAEA AQAEPVQGE
Length:499
Mass (Da):52,535
Last modified:January 23, 2007 - v1
Checksum:iF116A0CEA09ED72A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70323.1.
RefSeqiYP_916019.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70323; ABL70323; Pden_2231.
GeneIDi4579285.
KEGGipde:Pden_2231.
PATRICi22855587. VBIParDen97112_2162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70323.1 .
RefSeqi YP_916019.1. NC_008686.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_2231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL70323 ; ABL70323 ; Pden_2231 .
GeneIDi 4579285.
KEGGi pde:Pden_2231.
PATRICi 22855587. VBIParDen97112_2162.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100795.
KOi K00343.
OMAi IDKLSWI.
OrthoDBi EOG64JFNZ.

Enzyme and pathway databases

BioCyci PDEN318586:GCVQ-2271-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.
  2. "Assembly of respiratory complexes I, III, and IV into NADH oxidase supercomplex stabilizes complex I in Paracoccus denitrificans."
    Stroh A., Anderka O., Pfeiffer K., Yagi T., Finel M., Ludwig B., Schagger H.
    J. Biol. Chem. 279:5000-5007(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN NADH OXIDASE SUPERCOMPLEX, SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNUON_PARDP
AccessioniPrimary (citable) accession number: A1B479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3