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A1B475

- TRMB_PARDP

UniProt

A1B475 - TRMB_PARDP

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681S-adenosyl-L-methionineUniRule annotation
Binding sitei93 – 931S-adenosyl-L-methionineUniRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionineUniRule annotation
Active sitei142 – 1421By similarity
Binding sitei142 – 1421S-adenosyl-L-methionineUniRule annotation
Binding sitei146 – 1461SubstrateUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2267-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Pden_2227
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233tRNA (guanine-N(7)-)-methyltransferasePRO_0000288194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_2227.

Structurei

3D structure databases

ProteinModelPortaliA1B475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni211 – 2144Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073969.
KOiK03439.
OMAiRAFYGRR.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1B475-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEFDPNPPR RNFYGRRHGK TLRQSQKGYL SEDLGSLRPR GITVQENPER
60 70 80 90 100
KPVAPSTIFG DDRPVWLEVG FGGGEHMVHM AARYPEIGII GCEPFINGVA
110 120 130 140 150
MLLGKIRAAG VENVSVHPGD ARDLMDVLPD ASIDKAFLNY PDPWPKARHH
160 170 180 190 200
RRRFVTPEHL IPLARVMKPG AEFRVATDIP DYVRQTLEEV PQAGFDLVAE
210 220 230
GPQAWEDWPS TRYEQKALRE GRVPHYVTFR RRS
Length:233
Mass (Da):26,471
Last modified:January 23, 2007 - v1
Checksum:iC3FC3A378E52A6A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70319.1.
RefSeqiWP_011748514.1. NC_008686.1.
YP_916015.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70319; ABL70319; Pden_2227.
GeneIDi4579203.
KEGGipde:Pden_2227.
PATRICi22855579. VBIParDen97112_2158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL70319.1 .
RefSeqi WP_011748514.1. NC_008686.1.
YP_916015.1. NC_008686.1.

3D structure databases

ProteinModelPortali A1B475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_2227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL70319 ; ABL70319 ; Pden_2227 .
GeneIDi 4579203.
KEGGi pde:Pden_2227.
PATRICi 22855579. VBIParDen97112_2158.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073969.
KOi K03439.
OMAi RAFYGRR.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PDEN318586:GCVQ-2267-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiTRMB_PARDP
AccessioniPrimary (citable) accession number: A1B475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3