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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Substrate; in homodimeric partnerUniRule annotation1
Binding sitei177SubstrateUniRule annotation1
Active sitei179Proton acceptorUniRule annotation1
Binding sitei181SubstrateUniRule annotation1
Metal bindingi205Magnesium; via carbamate groupUniRule annotation1
Metal bindingi207MagnesiumUniRule annotation1
Metal bindingi208MagnesiumUniRule annotation1
Active sitei297Proton acceptorUniRule annotation1
Binding sitei298SubstrateUniRule annotation1
Binding sitei330SubstrateUniRule annotation1
Sitei337Transition state stabilizerUniRule annotation1
Binding sitei382SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processCalvin cycle, Carbon dioxide fixation
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciPDEN318586:G1GW1-1700-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Ordered Locus Names:Pden_1699
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002999671 – 487Ribulose bisphosphate carboxylase large chainAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205N6-carboxylysineUniRule annotation1

Proteomic databases

PRIDEiA1B2Q2

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Protein-protein interaction databases

STRINGi318586.Pden_1699

Structurei

3D structure databases

ProteinModelPortaliA1B2Q2
SMRiA1B2Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DT1 Bacteria
COG1850 LUCA
HOGENOMiHOG000230831
KOiK01601
OMAiHRAMHAA
OrthoDBiPOG091H14UZ

Family and domain databases

CDDicd08212 RuBisCO_large_I, 1 hit
Gene3Di3.20.20.110, 1 hit
3.30.70.150, 1 hit
HAMAPiMF_01338 RuBisCO_L_type1, 1 hit
InterProiView protein in InterPro
IPR033966 RuBisCO
IPR020878 RuBisCo_large_chain_AS
IPR000685 RuBisCO_lsu_C
IPR036376 RuBisCO_lsu_C_sf
IPR017443 RuBisCO_lsu_fd_N
IPR036422 RuBisCO_lsu_N_sf
IPR020888 RuBisCO_lsuI
PfamiView protein in Pfam
PF00016 RuBisCO_large, 1 hit
PF02788 RuBisCO_large_N, 1 hit
SFLDiSFLDS00014 RuBisCO, 1 hit
SUPFAMiSSF51649 SSF51649, 1 hit
SSF54966 SSF54966, 1 hit
PROSITEiView protein in PROSITE
PS00157 RUBISCO_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

A1B2Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEMSKSEIT DKKKRYAAGV LKYAQMGYWD GDYQPKDTDI LALFRITPQD
60 70 80 90 100
GVDPIEAAAA VAGESSTATW TVVWTDRLTA CDQYRAKAYK VEPVPGQEGQ
110 120 130 140 150
YFCYVAYDLI LFEEGSIANV TASIIGNVFS FKPLLAARLE DMRFPVAYMK
160 170 180 190 200
TFAGPPTGIV VERERLDKFG RPLLGATTKP KLGLSGKNYG RVVYEGLKGG
210 220 230 240 250
LDFMKDDENI NSQPFMHWRD RFLYCMEAVN KATAVTGEVK GHYLNITAGT
260 270 280 290 300
MEEMYRRAEL AKELGSVIVM VDLIVGWTAI QSISNWCRQN DMILHMHRAG
310 320 330 340 350
HGTYTRQKNH GISFRVIAKW LRMAGVDHLH CGTAVGKLEG DPLTVQGYYN
360 370 380 390 400
TCREMVNEVD LPRGIFFEQD WGNLKKVMPV ASGGIHAGQM HQLLDLFGDD
410 420 430 440 450
VVLQFGGGTI GHPMGIQAGA TANRVALEAM VLARNEGVDL KTEGPEVLRR
460 470 480
AAKWCKPLEA ALDVWGNITF NYTSTDTSDF VPTASVS
Length:487
Mass (Da):53,971
Last modified:January 23, 2007 - v1
Checksum:i07BD6810EEA63615
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA Translation: ABL69796.1
RefSeqiWP_011747994.1, NC_008686.1

Genome annotation databases

EnsemblBacteriaiABL69796; ABL69796; Pden_1699
KEGGipde:Pden_1699

Similar proteinsi

Entry informationi

Entry nameiRBL_PARDP
AccessioniPrimary (citable) accession number: A1B2Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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