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A1B2Q2

- RBL_PARDP

UniProt

A1B2Q2 - RBL_PARDP

Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271Substrate; in homodimeric partnerUniRule annotation
    Binding sitei177 – 1771SubstrateUniRule annotation
    Active sitei179 – 1791Proton acceptorUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation
    Metal bindingi205 – 2051Magnesium; via carbamate groupUniRule annotation
    Metal bindingi207 – 2071MagnesiumUniRule annotation
    Metal bindingi208 – 2081MagnesiumUniRule annotation
    Active sitei297 – 2971Proton acceptorUniRule annotation
    Binding sitei298 – 2981SubstrateUniRule annotation
    Binding sitei330 – 3301SubstrateUniRule annotation
    Sitei337 – 3371Transition state stabilizerUniRule annotation
    Binding sitei382 – 3821SubstrateUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. monooxygenase activity Source: UniProtKB-KW
    3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. reductive pentose-phosphate cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Calvin cycle, Carbon dioxide fixation

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciPDEN318586:GCVQ-1717-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCO large subunitUniRule annotation
    Gene namesi
    Name:cbbLUniRule annotation
    Ordered Locus Names:Pden_1699
    OrganismiParacoccus denitrificans (strain Pd 1222)
    Taxonomic identifieri318586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
    ProteomesiUP000000361: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Ribulose bisphosphate carboxylase large chainPRO_0000299967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei205 – 2051N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi318586.Pden_1699.

    Structurei

    3D structure databases

    ProteinModelPortaliA1B2Q2.
    SMRiA1B2Q2. Positions 12-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1850.
    HOGENOMiHOG000230831.
    KOiK01601.
    OMAiCTPLKQA.
    OrthoDBiEOG6ZKXMS.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPiMF_01338. RuBisCO_L_type1.
    InterProiIPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1B2Q2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEMSKSEIT DKKKRYAAGV LKYAQMGYWD GDYQPKDTDI LALFRITPQD    50
    GVDPIEAAAA VAGESSTATW TVVWTDRLTA CDQYRAKAYK VEPVPGQEGQ 100
    YFCYVAYDLI LFEEGSIANV TASIIGNVFS FKPLLAARLE DMRFPVAYMK 150
    TFAGPPTGIV VERERLDKFG RPLLGATTKP KLGLSGKNYG RVVYEGLKGG 200
    LDFMKDDENI NSQPFMHWRD RFLYCMEAVN KATAVTGEVK GHYLNITAGT 250
    MEEMYRRAEL AKELGSVIVM VDLIVGWTAI QSISNWCRQN DMILHMHRAG 300
    HGTYTRQKNH GISFRVIAKW LRMAGVDHLH CGTAVGKLEG DPLTVQGYYN 350
    TCREMVNEVD LPRGIFFEQD WGNLKKVMPV ASGGIHAGQM HQLLDLFGDD 400
    VVLQFGGGTI GHPMGIQAGA TANRVALEAM VLARNEGVDL KTEGPEVLRR 450
    AAKWCKPLEA ALDVWGNITF NYTSTDTSDF VPTASVS 487
    Length:487
    Mass (Da):53,971
    Last modified:January 23, 2007 - v1
    Checksum:i07BD6810EEA63615
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000489 Genomic DNA. Translation: ABL69796.1.
    RefSeqiYP_915492.1. NC_008686.1.

    Genome annotation databases

    EnsemblBacteriaiABL69796; ABL69796; Pden_1699.
    GeneIDi4581325.
    KEGGipde:Pden_1699.
    PATRICi22854475. VBIParDen97112_1626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000489 Genomic DNA. Translation: ABL69796.1 .
    RefSeqi YP_915492.1. NC_008686.1.

    3D structure databases

    ProteinModelPortali A1B2Q2.
    SMRi A1B2Q2. Positions 12-481.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318586.Pden_1699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL69796 ; ABL69796 ; Pden_1699 .
    GeneIDi 4581325.
    KEGGi pde:Pden_1699.
    PATRICi 22854475. VBIParDen97112_1626.

    Phylogenomic databases

    eggNOGi COG1850.
    HOGENOMi HOG000230831.
    KOi K01601.
    OMAi CTPLKQA.
    OrthoDBi EOG6ZKXMS.

    Enzyme and pathway databases

    BioCyci PDEN318586:GCVQ-1717-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPi MF_01338. RuBisCO_L_type1.
    InterProi IPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pd 1222.

    Entry informationi

    Entry nameiRBL_PARDP
    AccessioniPrimary (citable) accession number: A1B2Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3