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A1B1M8 (FTHS_PARDP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs1
Ordered Locus Names:Pden_1317
AND
Name:fhs2
Ordered Locus Names:Pden_1580
OrganismParacoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP]
Taxonomic identifier318586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293050

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1B1M8 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: F998D8F43C47015E

FASTA55558,648
        10         20         30         40         50         60 
MKSDIQIARE AQKLPIAQIA GRLGLAEADF LPYGHDKAKI AHEAIAALAG RPQGRLILVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTTTVGLGD ALNRIGKRAT VCIREASLGP NFGMKGGAAG GGHAQIVPME 

       130        140        150        160        170        180 
DMNLHFTGDF HAVTSAHNLL AAMIDNHIHW GNALRIDPRR VTWRRVMDMN DRVLRQVVVA 

       190        200        210        220        230        240 
LGGPANGVPR ECGFDITVAS EVMAILCLAS DLADLQARLG RIVIGQTFDR RPVTAHDLGA 

       250        260        270        280        290        300 
EGAMTVLLRD ALQPNLVQTL ENNPALVHGG PFANIAHGCN SVMATRTALA LSDYVVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF LNIKCRLAGL QPAAAVLVAT VRALKMNGGV ARTDLGAENV AALRAGCANL 

       370        380        390        400        410        420 
GRHIQNLRRF GLPVVVAINH FSGDTEAEIA ALADYCRERG VQAVLCRHWA EGGKGAEDLA 

       430        440        450        460        470        480 
RAVVALAEGG ADFTPLYPDE MPLAEKIETI CHRIYGAGQV EFLPHIVERL EEWQAAGHGH 

       490        500        510        520        530        540 
LPVCMAKTQY SFSANPAALG APEGFTIPVR EVRLAAGAGF VVAICGDIMT MPGLPREPSA 

       550 
LRIGVDADGH VQGLF 

« Hide

References

[1]"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pd 1222.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000489 Genomic DNA. Translation: ABL69422.1.
CP000489 Genomic DNA. Translation: ABL69680.1.
RefSeqYP_915118.1. NC_008686.1.
YP_915376.1. NC_008686.1.

3D structure databases

ProteinModelPortalA1B1M8.
SMRA1B1M8. Positions 4-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING318586.Pden_1580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL69422; ABL69422; Pden_1317.
ABL69680; ABL69680; Pden_1580.
GeneID4579498.
4580843.
KEGGpde:Pden_1317.
pde:Pden_1580.
PATRIC22853783. VBIParDen97112_1283.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycPDEN318586:GCVQ-1333-MONOMER.
PDEN318586:GCVQ-1597-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PARDP
AccessionPrimary (citable) accession number: A1B1M8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways