SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1B1M8

- FTHS_PARDP

UniProt

A1B1M8 - FTHS_PARDP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Formate--tetrahydrofolate ligase
Gene
fhs1, Pden_1317
fhs2, Pden_1580
Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-1333-MONOMER.
PDEN318586:GCVQ-1597-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs1
Ordered Locus Names:Pden_1317
AND
Name:fhs2
Ordered Locus Names:Pden_1580
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000293050Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_1580.

Structurei

3D structure databases

ProteinModelPortaliA1B1M8.
SMRiA1B1M8. Positions 4-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1B1M8-1 [UniParc]FASTAAdd to Basket

« Hide

MKSDIQIARE AQKLPIAQIA GRLGLAEADF LPYGHDKAKI AHEAIAALAG    50
RPQGRLILVT AINPTPAGEG KTTTTVGLGD ALNRIGKRAT VCIREASLGP 100
NFGMKGGAAG GGHAQIVPME DMNLHFTGDF HAVTSAHNLL AAMIDNHIHW 150
GNALRIDPRR VTWRRVMDMN DRVLRQVVVA LGGPANGVPR ECGFDITVAS 200
EVMAILCLAS DLADLQARLG RIVIGQTFDR RPVTAHDLGA EGAMTVLLRD 250
ALQPNLVQTL ENNPALVHGG PFANIAHGCN SVMATRTALA LSDYVVTEAG 300
FGADLGAEKF LNIKCRLAGL QPAAAVLVAT VRALKMNGGV ARTDLGAENV 350
AALRAGCANL GRHIQNLRRF GLPVVVAINH FSGDTEAEIA ALADYCRERG 400
VQAVLCRHWA EGGKGAEDLA RAVVALAEGG ADFTPLYPDE MPLAEKIETI 450
CHRIYGAGQV EFLPHIVERL EEWQAAGHGH LPVCMAKTQY SFSANPAALG 500
APEGFTIPVR EVRLAAGAGF VVAICGDIMT MPGLPREPSA LRIGVDADGH 550
VQGLF 555
Length:555
Mass (Da):58,648
Last modified:January 23, 2007 - v1
Checksum:iF998D8F43C47015E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL69422.1.
CP000489 Genomic DNA. Translation: ABL69680.1.
RefSeqiYP_915118.1. NC_008686.1.
YP_915376.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL69422; ABL69422; Pden_1317.
ABL69680; ABL69680; Pden_1580.
GeneIDi4579498.
4580843.
KEGGipde:Pden_1317.
pde:Pden_1580.
PATRICi22853783. VBIParDen97112_1283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL69422.1 .
CP000489 Genomic DNA. Translation: ABL69680.1 .
RefSeqi YP_915118.1. NC_008686.1.
YP_915376.1. NC_008686.1.

3D structure databases

ProteinModelPortali A1B1M8.
SMRi A1B1M8. Positions 4-553.
ModBasei Search...

Protein-protein interaction databases

STRINGi 318586.Pden_1580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL69422 ; ABL69422 ; Pden_1317 .
ABL69680 ; ABL69680 ; Pden_1580 .
GeneIDi 4579498.
4580843.
KEGGi pde:Pden_1317.
pde:Pden_1580.
PATRICi 22853783. VBIParDen97112_1283.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PDEN318586:GCVQ-1333-MONOMER.
PDEN318586:GCVQ-1597-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiFTHS_PARDP
AccessioniPrimary (citable) accession number: A1B1M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi