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A1B1M8

- FTHS_PARDP

UniProt

A1B1M8 - FTHS_PARDP

Protein

Formate--tetrahydrofolate ligase

Gene

fhs1

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Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPDEN318586:GCVQ-1333-MONOMER.
    PDEN318586:GCVQ-1597-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhs1UniRule annotation
    Ordered Locus Names:Pden_1317
    AND
    Name:fhs2UniRule annotation
    Ordered Locus Names:Pden_1580
    OrganismiParacoccus denitrificans (strain Pd 1222)
    Taxonomic identifieri318586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
    ProteomesiUP000000361: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000293050Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi318586.Pden_1580.

    Structurei

    3D structure databases

    ProteinModelPortaliA1B1M8.
    SMRiA1B1M8. Positions 4-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiNTIVQRI.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1B1M8-1 [UniParc]FASTAAdd to Basket

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    MKSDIQIARE AQKLPIAQIA GRLGLAEADF LPYGHDKAKI AHEAIAALAG    50
    RPQGRLILVT AINPTPAGEG KTTTTVGLGD ALNRIGKRAT VCIREASLGP 100
    NFGMKGGAAG GGHAQIVPME DMNLHFTGDF HAVTSAHNLL AAMIDNHIHW 150
    GNALRIDPRR VTWRRVMDMN DRVLRQVVVA LGGPANGVPR ECGFDITVAS 200
    EVMAILCLAS DLADLQARLG RIVIGQTFDR RPVTAHDLGA EGAMTVLLRD 250
    ALQPNLVQTL ENNPALVHGG PFANIAHGCN SVMATRTALA LSDYVVTEAG 300
    FGADLGAEKF LNIKCRLAGL QPAAAVLVAT VRALKMNGGV ARTDLGAENV 350
    AALRAGCANL GRHIQNLRRF GLPVVVAINH FSGDTEAEIA ALADYCRERG 400
    VQAVLCRHWA EGGKGAEDLA RAVVALAEGG ADFTPLYPDE MPLAEKIETI 450
    CHRIYGAGQV EFLPHIVERL EEWQAAGHGH LPVCMAKTQY SFSANPAALG 500
    APEGFTIPVR EVRLAAGAGF VVAICGDIMT MPGLPREPSA LRIGVDADGH 550
    VQGLF 555
    Length:555
    Mass (Da):58,648
    Last modified:January 23, 2007 - v1
    Checksum:iF998D8F43C47015E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000489 Genomic DNA. Translation: ABL69422.1.
    CP000489 Genomic DNA. Translation: ABL69680.1.
    RefSeqiYP_915118.1. NC_008686.1.
    YP_915376.1. NC_008686.1.

    Genome annotation databases

    EnsemblBacteriaiABL69422; ABL69422; Pden_1317.
    ABL69680; ABL69680; Pden_1580.
    GeneIDi4579498.
    4580843.
    KEGGipde:Pden_1317.
    pde:Pden_1580.
    PATRICi22853783. VBIParDen97112_1283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000489 Genomic DNA. Translation: ABL69422.1 .
    CP000489 Genomic DNA. Translation: ABL69680.1 .
    RefSeqi YP_915118.1. NC_008686.1.
    YP_915376.1. NC_008686.1.

    3D structure databases

    ProteinModelPortali A1B1M8.
    SMRi A1B1M8. Positions 4-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318586.Pden_1580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL69422 ; ABL69422 ; Pden_1317 .
    ABL69680 ; ABL69680 ; Pden_1580 .
    GeneIDi 4579498.
    4580843.
    KEGGi pde:Pden_1317.
    pde:Pden_1580.
    PATRICi 22853783. VBIParDen97112_1283.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi NTIVQRI.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci PDEN318586:GCVQ-1333-MONOMER.
    PDEN318586:GCVQ-1597-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pd 1222.

    Entry informationi

    Entry nameiFTHS_PARDP
    AccessioniPrimary (citable) accession number: A1B1M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3