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A1B1M8

- FTHS_PARDP

UniProt

A1B1M8 - FTHS_PARDP

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs1

more
Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-1333-MONOMER.
PDEN318586:GCVQ-1597-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Ordered Locus Names:Pden_1317
AND
Name:fhs2UniRule annotation
Ordered Locus Names:Pden_1580
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000293050Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_1580.

Structurei

3D structure databases

ProteinModelPortaliA1B1M8.
SMRiA1B1M8. Positions 4-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1B1M8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIQIARE AQKLPIAQIA GRLGLAEADF LPYGHDKAKI AHEAIAALAG
60 70 80 90 100
RPQGRLILVT AINPTPAGEG KTTTTVGLGD ALNRIGKRAT VCIREASLGP
110 120 130 140 150
NFGMKGGAAG GGHAQIVPME DMNLHFTGDF HAVTSAHNLL AAMIDNHIHW
160 170 180 190 200
GNALRIDPRR VTWRRVMDMN DRVLRQVVVA LGGPANGVPR ECGFDITVAS
210 220 230 240 250
EVMAILCLAS DLADLQARLG RIVIGQTFDR RPVTAHDLGA EGAMTVLLRD
260 270 280 290 300
ALQPNLVQTL ENNPALVHGG PFANIAHGCN SVMATRTALA LSDYVVTEAG
310 320 330 340 350
FGADLGAEKF LNIKCRLAGL QPAAAVLVAT VRALKMNGGV ARTDLGAENV
360 370 380 390 400
AALRAGCANL GRHIQNLRRF GLPVVVAINH FSGDTEAEIA ALADYCRERG
410 420 430 440 450
VQAVLCRHWA EGGKGAEDLA RAVVALAEGG ADFTPLYPDE MPLAEKIETI
460 470 480 490 500
CHRIYGAGQV EFLPHIVERL EEWQAAGHGH LPVCMAKTQY SFSANPAALG
510 520 530 540 550
APEGFTIPVR EVRLAAGAGF VVAICGDIMT MPGLPREPSA LRIGVDADGH

VQGLF
Length:555
Mass (Da):58,648
Last modified:January 23, 2007 - v1
Checksum:iF998D8F43C47015E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL69422.1.
CP000489 Genomic DNA. Translation: ABL69680.1.
RefSeqiYP_915118.1. NC_008686.1.
YP_915376.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL69422; ABL69422; Pden_1317.
ABL69680; ABL69680; Pden_1580.
GeneIDi4579498.
4580843.
KEGGipde:Pden_1317.
pde:Pden_1580.
PATRICi22853783. VBIParDen97112_1283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000489 Genomic DNA. Translation: ABL69422.1 .
CP000489 Genomic DNA. Translation: ABL69680.1 .
RefSeqi YP_915118.1. NC_008686.1.
YP_915376.1. NC_008686.1.

3D structure databases

ProteinModelPortali A1B1M8.
SMRi A1B1M8. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_1580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL69422 ; ABL69422 ; Pden_1317 .
ABL69680 ; ABL69680 ; Pden_1580 .
GeneIDi 4579498.
4580843.
KEGGi pde:Pden_1317.
pde:Pden_1580.
PATRICi 22853783. VBIParDen97112_1283.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PDEN318586:GCVQ-1333-MONOMER.
PDEN318586:GCVQ-1597-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiFTHS_PARDP
AccessioniPrimary (citable) accession number: A1B1M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3