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A1B1J4 (AROB_PARDP) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Pden_1283
OrganismParacoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP]
Taxonomic identifier318586 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3673673-dehydroquinate synthase HAMAP MF_00110
PRO_1000117494

Sequences

Sequence LengthMass (Da)Tools
A1B1J4 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 318CC68884CA2018

FASTA36738,683
        10         20         30         40         50         60 
MSIDTVHVDL GARSYDVRIG QGLLARAGEE IVALAGPRRV AILTDETVAA LHLPALRESL 

        70         80         90        100        110        120 
AGQGIEAPAL ALPAGEATKC WAELGRAVEW LLAQRIERKD LVIALGGGVI GDLAGFAAAI 

       130        140        150        160        170        180 
LRRGVRFVQI PTTLLAQVDS SVGGKTGINS PQGKNLIGAF HQPALVLADI DVLTTLSPRD 

       190        200        210        220        230        240 
FRAGYGEVAK YGLLGDEGFF EWLEANAAGL ASDPALRQRA VRHSVEMKAG IVQRDETEQG 

       250        260        270        280        290        300 
ERALLNLGHT FGHALESATG YSDRLLHGEG VAIGCALAFE LSAKMGLCSQ EAPSRVAAHL 

       310        320        330        340        350        360 
AAMGMPARIA DIPGDLPDDE ALIGLMAQDK KVQDGRLRFV LAHGIGRAFV TDAVDPALLR 


QVLAQSR

« Hide

References

[1]"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pd 1222.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000489 Genomic DNA. Translation: ABL69388.1.
RefSeqYP_915084.1. NC_008686.1.

3D structure databases

ProteinModelPortalA1B1J4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1B1J4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4580902.
GenomeReviewsGene locus Pden_1283 in contig CP000489_GR.
KEGGpde:Pden_1283.
PATRIC22853713. VBIParDen97112_1249.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBA1B1J4.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PARDP
AccessionPrimary (citable) accession number: A1B1J4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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