A1B1H7 (CLPX_PARDP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX

Gene names

Name:	clpX
Ordered Locus Names:	Pden_1266

Organism

Paracoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP]

Taxonomic identifier

318586 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus › Paracoccus denitrificans

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175
Subunit structure	Heterodimer of ClpP and ClpX By similarity. HAMAP-Rule MF_00175
Sequence similarities	Belongs to the ClpX chaperone family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175		PRO_1000024605
Regions
	Zinc finger	15 – 40	26	C4-type HAMAP-Rule MF_00175
	Nucleotide binding	117 – 124	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A1B1H7 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 1BBDEC856945C295	FASTA	421	45,925
	10 20 30 40 50 60 MANPTGGDSK NTLYCSFCGK SQHEVRKLIA GPTVFICDEC VELCMDIIRE ETKSSALKSG 70 80 90 100 110 120 DGVPTPREIC NVLDDYVIGQ EHAKRVLSVA VHNHYKRLNH SSKTDIELAK SNILLIGPTG 130 140 150 160 170 180 CGKTLLAQTL ARILDVPFTM ADATTLTEAG YVGEDVENII LKLLQASEYN VERAQRGIVY 190 200 210 220 230 240 IDEVDKITRK SDNPSITRDV SGEGVQQALL KIMEGTVASV PPQGGRKHPQ QEFLQVDTTN 250 260 270 280 290 300 ILFICGGAFA GLDRIIAQRN KGTAMGFGAA VKEDDDKGVG ELFKQLEPED LLKFGLIPEF 310 320 330 340 350 360 VGRLPVIATL GDLDEQALIT ILTQPKNALV KQYQRLFDLE SVKLTFTEDA LTAIAKRAIK 370 380 390 400 410 420 RKTGARGLRS IMEDILLDTM FDLPGMDSVE EVVVNEEAVD NPTAKPLLIH TDSKKETASA G

References

[1]

"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pd 1222.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000489 Genomic DNA. Translation: ABL69371.1.
RefSeq	YP_915067.1. NC_008686.1.
3D structure databases
ProteinModelPortal	A1B1H7.
SMR	A1B1H7. Positions 13-51.
ModBase	Search...
Protein-protein interaction databases
STRING	318586.Pden_1266.
Proteomic databases
PRIDE	A1B1H7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABL69371; ABL69371; Pden_1266.
GeneID	4580305.
KEGG	pde:Pden_1266.
PATRIC	22853679. VBIParDen97112_1232.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1219.
HOGENOM	HOG000010093.
KO	K03544.
OMA	YVIGQQQ.
ProtClustDB	PRK05342.
Enzyme and pathway databases
BioCyc	PDEN318586:GCVQ-1281-MONOMER.
Family and domain databases
HAMAP	MF_00175. ClpX.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR019489. Clp_ATPase_C. IPR004487. Clp_protease_ATP-bd_su_ClpX. IPR027417. P-loop_NTPase. IPR010603. Znf_CppX_C4. [Graphical view]
PANTHER	PTHR11262:SF4. PTHR11262:SF4. 1 hit.
Pfam	PF07724. AAA_2. 1 hit. PF10431. ClpB_D2-small. 1 hit. PF06689. zf-C4_ClpX. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM01086. ClpB_D2-small. 1 hit. SM00994. zf-C4_ClpX. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00382. clpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CLPX_PARDP

Accession

Primary (citable) accession number: A1B1H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program