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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Zn2+UniRule annotation, Mg2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 divalent metal cation per subunit. Can use ions such as Zn2+, Mg2+ or Co2+.UniRule annotation

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126SubstrateUniRule annotation1
Binding sitei127SubstrateUniRule annotation1
Metal bindingi160Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi205Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi260Divalent metal cation; shared with dimeric partnerUniRule annotation1
Binding sitei268SubstrateUniRule annotation1
Binding sitei277SubstrateUniRule annotation1
Binding sitei286SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridoxine biosynthesis
LigandCobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciPDEN318586:G1GW1-903-MONOMER
UniPathwayiUPA00244; UER00312

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:Pden_0898
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001282561 – 3224-hydroxythreonine-4-phosphate dehydrogenaseAdd BLAST322

Proteomic databases

PRIDEiA1B0G5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi318586.Pden_0898

Structurei

3D structure databases

ProteinModelPortaliA1B0G5
SMRiA1B0G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEZ Bacteria
COG1995 LUCA
HOGENOMiHOG000221593
KOiK00097
OMAiAPVHKGV
OrthoDBiPOG091H03XD

Family and domain databases

HAMAPiMF_00536 PdxA, 1 hit
InterProiView protein in InterPro
IPR037510 PdxA
IPR005255 PdxA_fam
PANTHERiPTHR30004 PTHR30004, 1 hit
PfamiView protein in Pfam
PF04166 PdxA, 1 hit
TIGRFAMsiTIGR00557 pdxA, 1 hit

Sequencei

Sequence statusi: Complete.

A1B0G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEARPIILT CGEPAGVGPE LAPKALASGV PFVFLGDPRH LPEGTAWAEV
60 70 80 90 100
TAPGEPVADG VLAVLRHDFP APARPGQPDP ANAPAVIEVI ARAVDLAMSG
110 120 130 140 150
AAGGICTLPI NKEALKRGAG FGFPGHTEYL AHLAGDVPVV MMLASTTVQP
160 170 180 190 200
PCRVVPVTIH IPLSEVPLAL TPLRLEQAIR ITDAAMRRDF GLAQPRLAIA
210 220 230 240 250
GLNPHAGENG VMGDEEARWM APLIERLRRE GFDLRGPLPA DTMFHPAARA
260 270 280 290 300
RYDAALCAYH DQALIPIKTL DFAGGVNITL GLPFVRTSPD HGTAFDIAGQ
310 320
GIADAESVIA ALRMAHEMAA RR
Length:322
Mass (Da):33,869
Last modified:January 23, 2007 - v1
Checksum:i60B2EF5329401A54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA Translation: ABL69009.1
RefSeqiWP_011747237.1, NC_008686.1

Genome annotation databases

EnsemblBacteriaiABL69009; ABL69009; Pden_0898
KEGGipde:Pden_0898

Similar proteinsi

Entry informationi

Entry nameiPDXA_PARDP
AccessioniPrimary (citable) accession number: A1B0G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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