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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei242ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDEN318586:G1GW1-891-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Pden_0884
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677291 – 441Glutamate--tRNA ligase 1Add BLAST441

Proteomic databases

PRIDEiA1B0F1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi318586.Pden_0884

Structurei

3D structure databases

ProteinModelPortaliA1B0F1
SMRiA1B0F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi239 – 243"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1B0F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTRFAPSP TGHIHVGNLR TALMNYLIAR KAGGTFILRL DDTDRERSKQ
60 70 80 90 100
EYADGIQRDL EWLGLTWDRI ERQSDRLDRY AEAAEGLRAA GRLYEVFETP
110 120 130 140 150
TELDLKRKKQ LNMGKPPVYD RAGLKLSAED KDRLRAEGRA GYWRFLLDQE
160 170 180 190 200
RIEWADGILG DISIDAASVS DPVLIRADGQ VLYTFASSVD DAEMGVTHIV
210 220 230 240 250
RGADHVTNTA TQIQIIRALG SEPPAFAHHS LLTGAQGEEL SKRLGTLSIR
260 270 280 290 300
DLRESGVAPE ALLSLMARLG SSQPVELKMS LDELAEGFDL GQFGASPTKF
310 320 330 340 350
DAEDLWPLTR EANQSRPLAE VRDRIAALGV PDELVERFWR VASQNITKLD
360 370 380 390 400
DLAGWWQIFS TGAEPQIDPE DADFIAEAMK LLPPPPYTDA TWGEFTNAVK
410 420 430 440
QATGRKGKGL FMPLRKALTG QAHGPDMSEV MPLLQVVRAR G
Length:441
Mass (Da):48,902
Last modified:January 23, 2007 - v1
Checksum:iF686B873732310FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA Translation: ABL68995.1
RefSeqiWP_011747223.1, NC_008686.1

Genome annotation databases

EnsemblBacteriaiABL68995; ABL68995; Pden_0884
KEGGipde:Pden_0884

Similar proteinsi

Entry informationi

Entry nameiSYE1_PARDP
AccessioniPrimary (citable) accession number: A1B0F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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