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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciPDEN318586:G1GW1-649-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Pden_0642
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201181 – 297Methionyl-tRNA formyltransferaseAdd BLAST297

Proteomic databases

PRIDEiA1AZR0

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_0642

Structurei

3D structure databases

ProteinModelPortaliA1AZR0
SMRiA1AZR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 111Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

A1AZR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVIFMGTPD FSVPALRAIA ARHQVVAVYS QPPRAAGRGQ KPRPSPVHRA
60 70 80 90 100
AEELGLPVRT PERLKSPQDQ GDFAALQADV AVVVAYGLIL PQPVLEAPWL
110 120 130 140 150
GCLNIHASLL PRWRGAAPIH RAIMAGDAET GVAIMQMEAG LDTGPVLAEA
160 170 180 190 200
RTTIGAEDTT ADLHDRLAEM GAALIVETLH RLPLPAEPQP AEGVTYAQKI
210 220 230 240 250
DKAEARIDWG RPAAQVDRQI RGLSPFPGAW CLIGGERVKL LRSRLAAGSG
260 270 280 290
APGRVLSGFT IACGEGAVEV LEAQREGKRP MPAAEILRGM ALPDRLD
Length:297
Mass (Da):31,631
Last modified:January 23, 2007 - v1
Checksum:i5C3AA55FC95D004C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA Translation: ABL68754.1
RefSeqiWP_011746987.1, NC_008686.1

Genome annotation databases

EnsemblBacteriaiABL68754; ABL68754; Pden_0642
KEGGipde:Pden_0642

Similar proteinsi

Entry informationi

Entry nameiFMT_PARDP
AccessioniPrimary (citable) accession number: A1AZR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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