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A1AZH9 (A1AZH9_PARDP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase HAMAP MF_00487
EC=1.1.1.37 HAMAP MF_00487
Gene names
Name:mdh HAMAP MF_00487
Ordered Locus Names:Pden_0561
OrganismParacoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP] EMBL ABL68673.1
Taxonomic identifier318586 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_00487 SAAS SAAS011275

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_00487 SAAS SAAS011275

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family. HAMAP MF_00487

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NAD By similarity HAMAP MF_00487
Nucleotide binding119 – 1213NAD By similarity HAMAP MF_00487

Sites

Active site1761Proton acceptor By similarity HAMAP MF_00487
Binding site341NAD By similarity HAMAP MF_00487
Binding site831Substrate By similarity HAMAP MF_00487
Binding site891Substrate By similarity HAMAP MF_00487
Binding site961NAD By similarity HAMAP MF_00487
Binding site1211Substrate By similarity HAMAP MF_00487
Binding site1521Substrate By similarity HAMAP MF_00487

Sequences

Sequence LengthMass (Da)Tools
A1AZH9 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 46F7CDFDC0DA9EE2

FASTA32033,534
        10         20         30         40         50         60 
MARPKIALIG AGQIGGTLAH LAAMKELGDV VLFDIAEGTP QGKALDIAQS GPSEGFDAVM 

        70         80         90        100        110        120 
KGANDYADIA GADVCIVTAG VPRKPGMSRD DLLGINLKVM KSVGEGIKQH APNAFVICIT 

       130        140        150        160        170        180 
NPLDAMVWAL REFSGLPHEK VVGMAGVLDS ARFRHFLSLE FGVSMRDVTA FVLGGHGDTM 

       190        200        210        220        230        240 
VPLTRYSTVG GIPLPDLVKM GWTTQEKLDA IVQRTRDGGA EIVGLLKTGS AFYAPATSAI 

       250        260        270        280        290        300 
EMAEAYLKDQ KRVLPCAAYV KGAYGLDGLY VGVPTVIGAG GIERVIDITL DKDEQAMFDK 

       310        320 
SVDAVKGLVT ACKGIDGTLA

« Hide

References

[1]"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000489 Genomic DNA. Translation: ABL68673.1.
RefSeqYP_914369.1. NC_008686.1.

3D structure databases

ProteinModelPortalA1AZH9.
SMRA1AZH9. Positions 3-313.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1AZH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4579682.
GenomeReviewsGene locus Pden_0561 in contig CP000489_GR.
KEGGpde:Pden_0561.
PATRIC22852258. VBIParDen97112_0529.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHBG566126.
OMANGRNRIL.
PhylomeDBA1AZH9.
ProtClustDBPRK06223.

Family and domain databases

HAMAPMF_00487. Malate_dehydrog_3.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00024.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1AZH9_PARDP
AccessionPrimary (citable) accession number: A1AZH9
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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