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A1AZA9 (UPPP_PARDP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Pden_0491
OrganismParacoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP]
Taxonomic identifier318586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290741

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane243 – 26321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1AZA9 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 0873C67660C62FB3

FASTA26728,705
        10         20         30         40         50         60 
MDHNTIVAAA LGLLEGLTEF IPVSSTGHVL LAGHFLGFDS PGRAFEVLIQ LGAIMAILGV 

        70         80         90        100        110        120 
YAGRLWRIFS SAPQDPRARR FILAVLLAFL PAVVIGVLAH RIIKEVLFET PTLIAVMLIV 

       130        140        150        160        170        180 
GGVVLLFVDR MANRPRHFSA EDFPLPMALK IGFIQCLAMI PGVSRSGATI VGALLLGADK 

       190        200        210        220        230        240 
RSAAEFSFFL SMPTMLGAFV YDLYKNRDIL DAAATGNIVI GFVCAFLAAV VVVRGLLNYV 

       250        260 
STYGYGLFAW WRIAVGVAVL LALQAGW 

« Hide

References

[1]"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pd 1222.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000489 Genomic DNA. Translation: ABL68603.1.
RefSeqYP_914299.1. NC_008686.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING318586.Pden_0491.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL68603; ABL68603; Pden_0491.
GeneID4579108.
KEGGpde:Pden_0491.
PATRIC22852112. VBIParDen97112_0458.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFAWWRIV.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycPDEN318586:GCVQ-500-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_PARDP
AccessionPrimary (citable) accession number: A1AZA9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families