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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Pden_0491
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
Proteomesi
  • UP000000361 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Transmembranei45 – 65HelicalUniRule annotationAdd BLAST21
Transmembranei82 – 102HelicalUniRule annotationAdd BLAST21
Transmembranei108 – 128HelicalUniRule annotationAdd BLAST21
Transmembranei143 – 163HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei213 – 233HelicalUniRule annotationAdd BLAST21
Transmembranei243 – 263HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002907411 – 267Undecaprenyl-diphosphataseAdd BLAST267

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_0491.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218356.
KOiK06153.
OMAiKVFDIAI.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AZA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHNTIVAAA LGLLEGLTEF IPVSSTGHVL LAGHFLGFDS PGRAFEVLIQ
60 70 80 90 100
LGAIMAILGV YAGRLWRIFS SAPQDPRARR FILAVLLAFL PAVVIGVLAH
110 120 130 140 150
RIIKEVLFET PTLIAVMLIV GGVVLLFVDR MANRPRHFSA EDFPLPMALK
160 170 180 190 200
IGFIQCLAMI PGVSRSGATI VGALLLGADK RSAAEFSFFL SMPTMLGAFV
210 220 230 240 250
YDLYKNRDIL DAAATGNIVI GFVCAFLAAV VVVRGLLNYV STYGYGLFAW
260
WRIAVGVAVL LALQAGW
Length:267
Mass (Da):28,705
Last modified:January 23, 2007 - v1
Checksum:i0873C67660C62FB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA. Translation: ABL68603.1.
RefSeqiWP_011746836.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL68603; ABL68603; Pden_0491.
KEGGipde:Pden_0491.
PATRICi22852112. VBIParDen97112_0458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000489 Genomic DNA. Translation: ABL68603.1.
RefSeqiWP_011746836.1. NC_008686.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318586.Pden_0491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL68603; ABL68603; Pden_0491.
KEGGipde:Pden_0491.
PATRICi22852112. VBIParDen97112_0458.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218356.
KOiK06153.
OMAiKVFDIAI.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_PARDP
AccessioniPrimary (citable) accession number: A1AZA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.