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A1AZ36 (A1AZ36_PARDP) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit B RuleBase RU003363 HAMAP MF_01898
EC=5.99.1.3 RuleBase RU003363 HAMAP MF_01898
Gene names
Name:gyrB HAMAP MF_01898
Ordered Locus Names:Pden_0416
OrganismParacoccus denitrificans (strain Pd 1222) [Complete proteome] [HAMAP] EMBL ABL68530.1
Taxonomic identifier318586 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus

Protein attributes

Sequence length812 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. RuleBase RU003363 HAMAP MF_01898

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. RuleBase RU003363 SAAS SAAS002288 HAMAP MF_01898

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01898

Subcellular location

Cytoplasm By similarity HAMAP MF_01898.

Sequence similarities

Belongs to the type II topoisomerase family. HAMAP MF_01898 RuleBase RU000380

Contains 1 Toprim domain. SAAS SAAS002288 HAMAP MF_01898

Sequences

Sequence LengthMass (Da)Tools
A1AZ36 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: E4493DDDCAA47463

FASTA81289,679
        10         20         30         40         50         60 
MTEPAPQTSD YGADSIKVLK GLEAVRKRPG MYIGDTDDGS GLHHMVTEVV DNGIDEALAG 

        70         80         90        100        110        120 
HADFVRVKIH ADGSVSVRDN GRGIPVDMHP TEGVSAAEVI MTQLHAGGKF DQNSYKVSGG 

       130        140        150        160        170        180 
LHGVGVSVVN ALSDWLELRI WRGGKEHYAR FENGDTVEHL RVVGDAEPGE KGTEVRFLAS 

       190        200        210        220        230        240 
SKEDRPDGTF LNREYSYKVL ENRLRELAFL NSGVRIILED ERPAEPLRTE LYYEGGVREF 

       250        260        270        280        290        300 
VKFIDRSKTP VMPEPIFITG ERNGIGIEVA MWWNDSYHET VLPFTNNIPQ RDGGTHLAGF 

       310        320        330        340        350        360 
RGALTRVINN YAQSSGAARK EKVDFTGDDA REGLTCVLSV KVPDPKFSSQ TKDKLVSSEV 

       370        380        390        400        410        420 
RPAVEGLIGE KLAEWFEENP AEAKSILGKI IEAALAREAA RKARELTRRK TAMDVASLPG 

       430        440        450        460        470        480 
KLADCQEKDP ALSELFIVEG DSAGGSAKQG RSRQNQAVLP LRGKILNVER ARFDRMLSSD 

       490        500        510        520        530        540 
QIGTLITALG TGIGRDEFNL DKLRYHKIVI MTDADVDGAH IRTLLLTFFF RQMPELIEAG 

       550        560        570        580        590        600 
HLYIAQPPLY KVSRGRSEVY LKDEAALEDY LIEQGVDGAS LRLGNGETLT GADLARVVEE 

       610        620        630        640        650        660 
ARVVRRILRA YPTHYPPHIT EQAAIAGALV QGRVDADAQG VANAVAQRLD MIAEEYERGW 

       670        680        690        700        710        720 
TGRPTQDAGI RLTRLLRGVE ESRTLDGPML RSAESRRLGA MTDALRDVYG QTAQLIRKDR 

       730        740        750        760        770        780 
GIPIHGPMSL LQAIFLEGEK GLSLQRYKGL GEMNPEQLWE TTLDPAARTM LQVRVEDLGE 

       790        800        810 
ADDIFTKLMG DVVEPRRDFI QQNALSVENL DI

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References

[1]"Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S., Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000489 Genomic DNA. Translation: ABL68530.1.
RefSeqYP_914226.1. NC_008686.1.

3D structure databases

ProteinModelPortalA1AZ36.
SMRA1AZ36. Positions 16-392.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1AZ36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4579462.
GenomeReviewsGene locus Pden_0416 in contig CP000489_GR.
KEGGpde:Pden_0416.
PATRIC22851988. VBIParDen97112_0397.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0187.
HOGENOMHBG304889.
OMADCSSRDP.
PhylomeDBA1AZ36.
ProtClustDBPRK14939.

Family and domain databases

HAMAPMF_01898. GyrB.
[Tree]
InterProIPR003594. ATPase-like_ATP-bd.
IPR011557. GyrB.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013759. Topo_IIA_B/N_ab.
IPR002288. Topo_IIA_B_C.
IPR013506. Topo_IIA_bsu_dom2.
IPR013760. Topo_IIA_cen.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
G3DSA:3.40.50.670. Topo_IIA_B/N_ab. 2 hits.
KOK02470.
PfamPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSPR00418. TPI2FAMILY.
SMARTSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMSSF55874. ATP_bd_ATPase. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01059. GyrB. 1 hit.
PROSITEPS00177. TOPOISOMERASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1AZ36_PARDP
AccessionPrimary (citable) accession number: A1AZ36
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info