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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (Rmag_0066)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14Manganese 2UniRule annotation1
Active sitei64Phosphoserine intermediateUniRule annotation1
Metal bindingi64Manganese 2UniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei193SubstrateUniRule annotation1
Binding sitei332SubstrateUniRule annotation1
Metal bindingi399Manganese 1UniRule annotation1
Metal bindingi403Manganese 1UniRule annotation1
Metal bindingi440Manganese 2UniRule annotation1
Metal bindingi441Manganese 2UniRule annotation1
Metal bindingi459Manganese 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciCRUT413404:G1G7M-1091-MONOMER
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Ordered Locus Names:Rmag_1070
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbiontsCandidatus Ruthia
Proteomesi
  • UP000002587 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000639981 – 5122,3-bisphosphoglycerate-independent phosphoglycerate mutaseAdd BLAST512

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi413404.Rmag_1070

Structurei

3D structure databases

ProteinModelPortaliA1AXW7
SMRiA1AXW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 156Substrate bindingUniRule annotation2
Regioni259 – 262Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJI Bacteria
COG0696 LUCA
HOGENOMiHOG000223664
KOiK15633
OMAiFMDGRDT
OrthoDBiPOG091H01EL

Family and domain databases

CDDicd16010 iPGM, 1 hit
Gene3Di3.40.1450.101 hit
3.40.720.102 hits
HAMAPiMF_01038 GpmI, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR011258 BPG-indep_PGM_N
IPR006124 Metalloenzyme
IPR036646 PGAM_B_sf
IPR005995 Pgm_bpd_ind
PANTHERiPTHR31637 PTHR31637, 1 hit
PfamiView protein in Pfam
PF06415 iPGM_N, 1 hit
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001492 IPGAM, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
SSF64158 SSF64158, 1 hit
TIGRFAMsiTIGR01307 pgm_bpd_ind, 1 hit

Sequencei

Sequence statusi: Complete.

A1AXW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSKKQTKLL LILDGWGYSE TIQNNAIALA NTPVWDKLNQ TFLHSLIHTS
60 70 80 90 100
GKDVGLPGKQ MGNSEVGHLN LGAGRIVKQD FTRIYNELQN GDFFRNPILK
110 120 130 140 150
NSLEYANDNN KAVHIMGLLS DGGVHSHEEQ IHAMLEMTHK QGCKNVYLHL
160 170 180 190 200
FTDGRDCAQK SAEKYIQKFE EKMAILGTGE IVSIIGRYFS MDRDNRWSRI
210 220 230 240 250
RCAYELIAKG KAKFLAQSAL HAVELAYARG ETDEFIQSTS IKIPISIKKG
260 270 280 290 300
DVLIFMNYRA DRARQITRAF TDENLQGFSR GTFVPTQFIC LTEYKKDFNL
310 320 330 340 350
PVAYPSSKLN NVLGKYLSNL GMTQLRIAET EKYAHVTFFL NGGVEQAFNG
360 370 380 390 400
EDRILIPSPD VATYDLQPEM SAFELTDALI ESIESQKYDL IICNFANTDM
410 420 430 440 450
VGHSGKLNAT IKAVETIDSC LGIIHKAMFA ISGEILITAD HGNAEQMINP
460 470 480 490 500
KTHEVHTAHT NNPVPLIFVS ERKADISEPE KGALSDIAPT LLAMMDIEKP
510
NEMTGNSLLT FK
Length:512
Mass (Da):57,202
Last modified:January 23, 2007 - v1
Checksum:iC973FDDE1F14E5AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000488 Genomic DNA Translation: ABL02774.1
RefSeqiWP_011738399.1, NC_008610.1

Genome annotation databases

EnsemblBacteriaiABL02774; ABL02774; Rmag_1070
KEGGirma:Rmag_1070

Similar proteinsi

Entry informationi

Entry nameiGPMI_RUTMC
AccessioniPrimary (citable) accession number: A1AXW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome