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A1AXP6

- TRMB_RUTMC

UniProt

A1AXP6 - TRMB_RUTMC

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, Rmag_0997
Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461S-adenosyl-L-methionine By similarity
Binding sitei73 – 731S-adenosyl-L-methionine By similarity
Binding sitei94 – 941Substrate By similarity
Binding sitei126 – 1261Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCRUT413404:GHM7-1032-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Rmag_0997
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000002587: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185tRNA (guanine-N(7)-)-methyltransferasePRO_0000288219Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi413404.Rmag_0997.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1664Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiTSATNDY.
OrthoDBiEOG6K6VBC.

Family and domain databases

InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AXP6-1 [UniParc]FASTAAdd to Basket

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MRLDLSKDKI NLDALFVKQQ KIDFDNGDSL LKIAINMPDI NFLDIEIYET    50
SINRLINKTH KYQLSNLKII QVDAHTKDNN FDSFQLFLSG PWYKKKYHKL 100
RLVQTAFLDL LSKTIIHNGK IHIATDWVRY VTTMMNALKN HLHFKNTQND 150
PIYSLRPGHR PITKFERRSH RPGHDVLDLI FKNEK 185
Length:185
Mass (Da):21,883
Last modified:January 23, 2007 - v1
Checksum:i7F98BCCB1F52422D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL02703.1.
RefSeqiYP_904174.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL02703; ABL02703; Rmag_0997.
GeneIDi4554948.
KEGGirma:Rmag_0997.
PATRICi32001791. VBICanRut45856_1100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL02703.1 .
RefSeqi YP_904174.1. NC_008610.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413404.Rmag_0997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL02703 ; ABL02703 ; Rmag_0997 .
GeneIDi 4554948.
KEGGi rma:Rmag_0997.
PATRICi 32001791. VBICanRut45856_1100.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi TSATNDY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CRUT413404:GHM7-1032-MONOMER.

Family and domain databases

InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTRMB_RUTMC
AccessioniPrimary (citable) accession number: A1AXP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3