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A1AXP6 (TRMB_RUTMC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (guanine-N(7)-)-methyltransferase
EC=2.1.1.33
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene names
Name:trmB
Ordered Locus Names:Rmag_0997
OrganismRuthia magnifica subsp. Calyptogena magnifica [Complete proteome] [HAMAP]
Taxonomic identifier413404 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › sulfur-oxidizing symbionts ›

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity. HAMAP-Rule MF_01057

Catalytic activity

S-adenosyl-L-methionine + guanine46 in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine46 in tRNA. HAMAP-Rule MF_01057

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP-Rule MF_01057

Sequence similarities

Belongs to the methyltransferase superfamily. TrmB family.

Ontologies

Keywords
   Biological processtRNA processing
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processRNA (guanine-N7)-methylation

Inferred from electronic annotation. Source: GOC

   Molecular_functiontRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185tRNA (guanine-N(7)-)-methyltransferase HAMAP-Rule MF_01057
PRO_0000288219

Regions

Region163 – 1664Substrate binding Potential

Sites

Binding site461S-adenosyl-L-methionine By similarity
Binding site731S-adenosyl-L-methionine By similarity
Binding site941Substrate By similarity
Binding site1261Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
A1AXP6 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 7F98BCCB1F52422D

FASTA18521,883
        10         20         30         40         50         60 
MRLDLSKDKI NLDALFVKQQ KIDFDNGDSL LKIAINMPDI NFLDIEIYET SINRLINKTH 

        70         80         90        100        110        120 
KYQLSNLKII QVDAHTKDNN FDSFQLFLSG PWYKKKYHKL RLVQTAFLDL LSKTIIHNGK 

       130        140        150        160        170        180 
IHIATDWVRY VTTMMNALKN HLHFKNTQND PIYSLRPGHR PITKFERRSH RPGHDVLDLI 


FKNEK

« Hide

References

[1]"The Calyptogena magnifica chemoautotrophic symbiont genome."
Newton I.L.G., Woyke T., Auchtung T.A., Dilly G.F., Dutton R.J., Fisher M.C., Fontanez K.M., Lau E., Stewart F.J., Richardson P.M., Barry K.W., Saunders E., Detter J.C., Wu D., Eisen J.A., Cavanaugh C.M.
Science 315:998-1000(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000488 Genomic DNA. Translation: ABL02703.1.
RefSeqYP_904174.1. NC_008610.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING413404.Rmag_0997.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL02703; ABL02703; Rmag_0997.
GeneID4554948.
KEGGrma:Rmag_0997.
PATRIC32001791. VBICanRut45856_1100.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0220.
HOGENOMHOG000073968.
KOK03439.

Enzyme and pathway databases

BioCycCRUT413404:GHM7-1038-MONOMER.
UniPathwayUPA00989.

Family and domain databases

HAMAPMF_01057. tRNA_methyltr_TrmB. Divergent sequence.
InterProIPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamPF02390. Methyltransf_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMB_RUTMC
AccessionPrimary (citable) accession number: A1AXP6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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