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A1AWV4 (CPDA_RUTMC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:Rmag_0669
OrganismRuthia magnifica subsp. Calyptogena magnifica [Complete proteome] [HAMAP]
Taxonomic identifier413404 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2342343',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413378

Regions

Nucleotide binding79 – 802cAMP By similarity

Sites

Metal binding111Metal cation 1 By similarity
Metal binding131Metal cation 1 By similarity
Metal binding491Metal cation 1 By similarity
Metal binding491Metal cation 2 By similarity
Metal binding791Metal cation 2 By similarity
Metal binding1451Metal cation 2 By similarity
Metal binding1841Metal cation 2 By similarity
Metal binding1861Metal cation 1 By similarity
Binding site131cAMP By similarity
Binding site491cAMP By similarity
Binding site1861cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1AWV4 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 75601DAEC907D5D5

FASTA23426,547
        10         20         30         40         50         60 
MMSHSFVQIS DCHIDNVEYA MGVNTHVNLK KIINKIINID TDALLISGDL THNGTITSYK 

        70         80         90        100        110        120 
TLQQILFPVQ IKLLVISGNH DIDNNLNTIF SKNLFSQFTL RKWEIISTNS VQTSKTSGFL 

       130        140        150        160        170        180 
TKNELKKLNF NLTQSIAKYI LIVLHHPIVP MNSTWDDSLS LENPKALFNV LDKYPKIQAI 

       190        200        210        220        230 
LFGHAHQAAE FSRLGVKIIS CPSTALQFNN ETRIGFNHYT LYDNGQLTID TQWI 

« Hide

References

[1]"The Calyptogena magnifica chemoautotrophic symbiont genome."
Newton I.L.G., Woyke T., Auchtung T.A., Dilly G.F., Dutton R.J., Fisher M.C., Fontanez K.M., Lau E., Stewart F.J., Richardson P.M., Barry K.W., Saunders E., Detter J.C., Wu D., Eisen J.A., Cavanaugh C.M.
Science 315:998-1000(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000488 Genomic DNA. Translation: ABL02411.1.
RefSeqYP_903882.1. NC_008610.1.

3D structure databases

ProteinModelPortalA1AWV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING413404.Rmag_0669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL02411; ABL02411; Rmag_0669.
GeneID4554602.
KEGGrma:Rmag_0669.
PATRIC32001053. VBICanRut45856_0739.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1409.
HOGENOMHOG000137387.
KOK03651.
OMAWQIIMLD.
OrthoDBEOG6QG8GQ.

Enzyme and pathway databases

BioCycCRUT413404:GHM7-695-MONOMER.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPDA_RUTMC
AccessionPrimary (citable) accession number: A1AWV4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families