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A1AWV4

- CPDA_RUTMC

UniProt

A1AWV4 - CPDA_RUTMC

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111Metal cation 1UniRule annotation
Metal bindingi13 – 131Metal cation 1UniRule annotation
Binding sitei13 – 131cAMPUniRule annotation
Metal bindingi49 – 491Metal cation 1UniRule annotation
Metal bindingi49 – 491Metal cation 2UniRule annotation
Binding sitei49 – 491cAMPUniRule annotation
Metal bindingi79 – 791Metal cation 2UniRule annotation
Metal bindingi145 – 1451Metal cation 2UniRule annotation
Metal bindingi184 – 1841Metal cation 2UniRule annotation
Metal bindingi186 – 1861Metal cation 1UniRule annotation
Binding sitei186 – 1861cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCRUT413404:GHM7-695-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Rmag_0669
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbiontsCandidatus Ruthia
ProteomesiUP000002587: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2342343',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413378Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi413404.Rmag_0669.

Structurei

3D structure databases

ProteinModelPortaliA1AWV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000137387.
KOiK03651.
OMAiWQIIMLD.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AWV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSHSFVQIS DCHIDNVEYA MGVNTHVNLK KIINKIINID TDALLISGDL
60 70 80 90 100
THNGTITSYK TLQQILFPVQ IKLLVISGNH DIDNNLNTIF SKNLFSQFTL
110 120 130 140 150
RKWEIISTNS VQTSKTSGFL TKNELKKLNF NLTQSIAKYI LIVLHHPIVP
160 170 180 190 200
MNSTWDDSLS LENPKALFNV LDKYPKIQAI LFGHAHQAAE FSRLGVKIIS
210 220 230
CPSTALQFNN ETRIGFNHYT LYDNGQLTID TQWI
Length:234
Mass (Da):26,547
Last modified:January 23, 2007 - v1
Checksum:i75601DAEC907D5D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000488 Genomic DNA. Translation: ABL02411.1.
RefSeqiWP_011738036.1. NC_008610.1.
YP_903882.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL02411; ABL02411; Rmag_0669.
GeneIDi4554602.
KEGGirma:Rmag_0669.
PATRICi32001053. VBICanRut45856_0739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000488 Genomic DNA. Translation: ABL02411.1 .
RefSeqi WP_011738036.1. NC_008610.1.
YP_903882.1. NC_008610.1.

3D structure databases

ProteinModelPortali A1AWV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413404.Rmag_0669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL02411 ; ABL02411 ; Rmag_0669 .
GeneIDi 4554602.
KEGGi rma:Rmag_0669.
PATRICi 32001053. VBICanRut45856_0739.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000137387.
KOi K03651.
OMAi WQIIMLD.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci CRUT413404:GHM7-695-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCPDA_RUTMC
AccessioniPrimary (citable) accession number: A1AWV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3