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A1AWV4

- CPDA_RUTMC

UniProt

A1AWV4 - CPDA_RUTMC

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, Rmag_0669
Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111Metal cation 1 By similarity
Metal bindingi13 – 131Metal cation 1 By similarity
Binding sitei13 – 131cAMP By similarity
Metal bindingi49 – 491Metal cation 1 By similarity
Metal bindingi49 – 491Metal cation 2 By similarity
Binding sitei49 – 491cAMP By similarity
Metal bindingi79 – 791Metal cation 2 By similarity
Metal bindingi145 – 1451Metal cation 2 By similarity
Metal bindingi184 – 1841Metal cation 2 By similarity
Metal bindingi186 – 1861Metal cation 1 By similarity
Binding sitei186 – 1861cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCRUT413404:GHM7-695-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:Rmag_0669
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000002587: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2342343',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000413378Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi413404.Rmag_0669.

Structurei

3D structure databases

ProteinModelPortaliA1AWV4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000137387.
KOiK03651.
OMAiWQIIMLD.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AWV4-1 [UniParc]FASTAAdd to Basket

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MMSHSFVQIS DCHIDNVEYA MGVNTHVNLK KIINKIINID TDALLISGDL    50
THNGTITSYK TLQQILFPVQ IKLLVISGNH DIDNNLNTIF SKNLFSQFTL 100
RKWEIISTNS VQTSKTSGFL TKNELKKLNF NLTQSIAKYI LIVLHHPIVP 150
MNSTWDDSLS LENPKALFNV LDKYPKIQAI LFGHAHQAAE FSRLGVKIIS 200
CPSTALQFNN ETRIGFNHYT LYDNGQLTID TQWI 234
Length:234
Mass (Da):26,547
Last modified:January 23, 2007 - v1
Checksum:i75601DAEC907D5D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL02411.1.
RefSeqiYP_903882.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL02411; ABL02411; Rmag_0669.
GeneIDi4554602.
KEGGirma:Rmag_0669.
PATRICi32001053. VBICanRut45856_0739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL02411.1 .
RefSeqi YP_903882.1. NC_008610.1.

3D structure databases

ProteinModelPortali A1AWV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413404.Rmag_0669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL02411 ; ABL02411 ; Rmag_0669 .
GeneIDi 4554602.
KEGGi rma:Rmag_0669.
PATRICi 32001053. VBICanRut45856_0739.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000137387.
KOi K03651.
OMAi WQIIMLD.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci CRUT413404:GHM7-695-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCPDA_RUTMC
AccessioniPrimary (citable) accession number: A1AWV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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