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A1AWV4

- CPDA_RUTMC

UniProt

A1AWV4 - CPDA_RUTMC

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi11 – 111Metal cation 1UniRule annotation
    Metal bindingi13 – 131Metal cation 1UniRule annotation
    Binding sitei13 – 131cAMPUniRule annotation
    Metal bindingi49 – 491Metal cation 1UniRule annotation
    Metal bindingi49 – 491Metal cation 2UniRule annotation
    Binding sitei49 – 491cAMPUniRule annotation
    Metal bindingi79 – 791Metal cation 2UniRule annotation
    Metal bindingi145 – 1451Metal cation 2UniRule annotation
    Metal bindingi184 – 1841Metal cation 2UniRule annotation
    Metal bindingi186 – 1861Metal cation 1UniRule annotation
    Binding sitei186 – 1861cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi79 – 802cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCRUT413404:GHM7-695-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:Rmag_0669
    OrganismiRuthia magnifica subsp. Calyptogena magnifica
    Taxonomic identifieri413404 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
    ProteomesiUP000002587: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2342343',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413378Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi413404.Rmag_0669.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AWV4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000137387.
    KOiK03651.
    OMAiWQIIMLD.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1AWV4-1 [UniParc]FASTAAdd to Basket

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    MMSHSFVQIS DCHIDNVEYA MGVNTHVNLK KIINKIINID TDALLISGDL    50
    THNGTITSYK TLQQILFPVQ IKLLVISGNH DIDNNLNTIF SKNLFSQFTL 100
    RKWEIISTNS VQTSKTSGFL TKNELKKLNF NLTQSIAKYI LIVLHHPIVP 150
    MNSTWDDSLS LENPKALFNV LDKYPKIQAI LFGHAHQAAE FSRLGVKIIS 200
    CPSTALQFNN ETRIGFNHYT LYDNGQLTID TQWI 234
    Length:234
    Mass (Da):26,547
    Last modified:January 23, 2007 - v1
    Checksum:i75601DAEC907D5D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000488 Genomic DNA. Translation: ABL02411.1.
    RefSeqiYP_903882.1. NC_008610.1.

    Genome annotation databases

    EnsemblBacteriaiABL02411; ABL02411; Rmag_0669.
    GeneIDi4554602.
    KEGGirma:Rmag_0669.
    PATRICi32001053. VBICanRut45856_0739.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000488 Genomic DNA. Translation: ABL02411.1 .
    RefSeqi YP_903882.1. NC_008610.1.

    3D structure databases

    ProteinModelPortali A1AWV4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 413404.Rmag_0669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL02411 ; ABL02411 ; Rmag_0669 .
    GeneIDi 4554602.
    KEGGi rma:Rmag_0669.
    PATRICi 32001053. VBICanRut45856_0739.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000137387.
    KOi K03651.
    OMAi WQIIMLD.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci CRUT413404:GHM7-695-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCPDA_RUTMC
    AccessioniPrimary (citable) accession number: A1AWV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3