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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11Metal cation 1UniRule annotation1
Metal bindingi13Metal cation 1UniRule annotation1
Binding sitei13cAMPUniRule annotation1
Metal bindingi49Metal cation 1UniRule annotation1
Metal bindingi49Metal cation 2UniRule annotation1
Binding sitei49cAMPUniRule annotation1
Metal bindingi79Metal cation 2UniRule annotation1
Metal bindingi145Metal cation 2UniRule annotation1
Metal bindingi184Metal cation 2UniRule annotation1
Metal bindingi186Metal cation 1UniRule annotation1
Binding sitei186cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 80cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCRUT413404:G1G7M-684-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Rmag_0669
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbiontsCandidatus Ruthia
Proteomesi
  • UP000002587 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133781 – 2343',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST234

Interactioni

Protein-protein interaction databases

STRINGi413404.Rmag_0669

Structurei

3D structure databases

ProteinModelPortaliA1AWV4
SMRiA1AWV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG Bacteria
COG1409 LUCA
HOGENOMiHOG000137387
KOiK03651
OMAiIPVFWIP
OrthoDBiPOG091H05L5

Family and domain databases

Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR026575 cAMP_Pdiest_CpdA
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

A1AWV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSHSFVQIS DCHIDNVEYA MGVNTHVNLK KIINKIINID TDALLISGDL
60 70 80 90 100
THNGTITSYK TLQQILFPVQ IKLLVISGNH DIDNNLNTIF SKNLFSQFTL
110 120 130 140 150
RKWEIISTNS VQTSKTSGFL TKNELKKLNF NLTQSIAKYI LIVLHHPIVP
160 170 180 190 200
MNSTWDDSLS LENPKALFNV LDKYPKIQAI LFGHAHQAAE FSRLGVKIIS
210 220 230
CPSTALQFNN ETRIGFNHYT LYDNGQLTID TQWI
Length:234
Mass (Da):26,547
Last modified:January 23, 2007 - v1
Checksum:i75601DAEC907D5D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000488 Genomic DNA Translation: ABL02411.1
RefSeqiWP_011738036.1, NC_008610.1

Genome annotation databases

EnsemblBacteriaiABL02411; ABL02411; Rmag_0669
KEGGirma:Rmag_0669

Similar proteinsi

Entry informationi

Entry nameiCPDA_RUTMC
AccessioniPrimary (citable) accession number: A1AWV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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