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A1AVX5

- GCH4_RUTMC

UniProt

A1AVX5 - GCH4_RUTMC

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei150 – 1501May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciCRUT413404:GHM7-314-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Rmag_0304
    OrganismiRuthia magnifica subsp. Calyptogena magnifica
    Taxonomic identifieri413404 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
    ProteomesiUP000002587: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264GTP cyclohydrolase FolE2PRO_0000289520Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi413404.Rmag_0304.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AVX5.
    SMRiA1AVX5. Positions 17-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiLIWFEDL.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1AVX5-1 [UniParc]FASTAAdd to Basket

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    MSAIHLPDTQ NSADTRQIII DKVGIKDITH PITYIDCDGN KIPTIGIFTM    50
    TVSLSERVKG THMSRFIEIL NEGPCEFSAH NFDKIIDKVR KRLESDIAHI 100
    TLNFTFFRRK KAPSSGVESM MDYQVTLYGT LNKDEVQVMM KVVVPVTSLC 150
    PCSKSISKYG AHNQRSHITI KAKAAKDKTL HIEDLIDLAE RKASCELYAI 200
    LKRDDEKVVT ERAYDNPAFV EDLVRDIAVD LNADDKISYY RLESENFESI 250
    HNHSAYALIE NQKC 264
    Length:264
    Mass (Da):29,971
    Last modified:January 23, 2007 - v1
    Checksum:iB6245A9B22438F98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000488 Genomic DNA. Translation: ABL02082.1.
    RefSeqiWP_011737707.1. NC_008610.1.
    YP_903553.1. NC_008610.1.

    Genome annotation databases

    EnsemblBacteriaiABL02082; ABL02082; Rmag_0304.
    GeneIDi4555419.
    KEGGirma:Rmag_0304.
    PATRICi32000239. VBICanRut45856_0347.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000488 Genomic DNA. Translation: ABL02082.1 .
    RefSeqi WP_011737707.1. NC_008610.1.
    YP_903553.1. NC_008610.1.

    3D structure databases

    ProteinModelPortali A1AVX5.
    SMRi A1AVX5. Positions 17-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 413404.Rmag_0304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL02082 ; ABL02082 ; Rmag_0304 .
    GeneIDi 4555419.
    KEGGi rma:Rmag_0304.
    PATRICi 32000239. VBICanRut45856_0347.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi LIWFEDL.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci CRUT413404:GHM7-314-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGCH4_RUTMC
    AccessioniPrimary (citable) accession number: A1AVX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3