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A1AVX5

- GCH4_RUTMC

UniProt

A1AVX5 - GCH4_RUTMC

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Rmag_0304
Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei150 – 1501May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCRUT413404:GHM7-314-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Rmag_0304
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000002587: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264GTP cyclohydrolase FolE2UniRule annotationPRO_0000289520Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi413404.Rmag_0304.

Structurei

3D structure databases

ProteinModelPortaliA1AVX5.
SMRiA1AVX5. Positions 17-263.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiLIWFEDL.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AVX5-1 [UniParc]FASTAAdd to Basket

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MSAIHLPDTQ NSADTRQIII DKVGIKDITH PITYIDCDGN KIPTIGIFTM    50
TVSLSERVKG THMSRFIEIL NEGPCEFSAH NFDKIIDKVR KRLESDIAHI 100
TLNFTFFRRK KAPSSGVESM MDYQVTLYGT LNKDEVQVMM KVVVPVTSLC 150
PCSKSISKYG AHNQRSHITI KAKAAKDKTL HIEDLIDLAE RKASCELYAI 200
LKRDDEKVVT ERAYDNPAFV EDLVRDIAVD LNADDKISYY RLESENFESI 250
HNHSAYALIE NQKC 264
Length:264
Mass (Da):29,971
Last modified:January 23, 2007 - v1
Checksum:iB6245A9B22438F98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL02082.1.
RefSeqiWP_011737707.1. NC_008610.1.
YP_903553.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL02082; ABL02082; Rmag_0304.
GeneIDi4555419.
KEGGirma:Rmag_0304.
PATRICi32000239. VBICanRut45856_0347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL02082.1 .
RefSeqi WP_011737707.1. NC_008610.1.
YP_903553.1. NC_008610.1.

3D structure databases

ProteinModelPortali A1AVX5.
SMRi A1AVX5. Positions 17-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413404.Rmag_0304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL02082 ; ABL02082 ; Rmag_0304 .
GeneIDi 4555419.
KEGGi rma:Rmag_0304.
PATRICi 32000239. VBICanRut45856_0347.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi LIWFEDL.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CRUT413404:GHM7-314-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGCH4_RUTMC
AccessioniPrimary (citable) accession number: A1AVX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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