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A1AVS5

- NUON_RUTMC

UniProt

A1AVS5 - NUON_RUTMC

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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciCRUT413404:GHM7-259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:Rmag_0250
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbiontsCandidatus Ruthia
ProteomesiUP000002587: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei42 – 6221HelicalUniRule annotationAdd
BLAST
Transmembranei79 – 9820HelicalUniRule annotationAdd
BLAST
Transmembranei113 – 13321HelicalUniRule annotationAdd
BLAST
Transmembranei134 – 15421HelicalUniRule annotationAdd
BLAST
Transmembranei167 – 18721HelicalUniRule annotationAdd
BLAST
Transmembranei211 – 23121HelicalUniRule annotationAdd
BLAST
Transmembranei248 – 26821HelicalUniRule annotationAdd
BLAST
Transmembranei279 – 29921HelicalUniRule annotationAdd
BLAST
Transmembranei313 – 33321HelicalUniRule annotationAdd
BLAST
Transmembranei335 – 35521HelicalUniRule annotationAdd
BLAST
Transmembranei378 – 39821HelicalUniRule annotationAdd
BLAST
Transmembranei408 – 42821HelicalUniRule annotationAdd
BLAST
Transmembranei457 – 47721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484NADH-quinone oxidoreductase subunit NPRO_0000391218Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi413404.Rmag_0250.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100795.
KOiK00343.
OMAiIEAQLYG.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AVS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNFIEFDTS SLWIALPEIF LLSAIVIVLL IDLFLDKNFK QVTYYLIQLS
60 70 80 90 100
LFITGLLAFN LIDHPQIIIF GGSFVLDNMA SVFKVFMMAA TMVAMVYSRH
110 120 130 140 150
YLRTHSLFRG EYFVLVLLSV LGMMVMVSGY SLLTLYLGLE ILSLSLYALI
160 170 180 190 200
AIARERADAI EAALKYFVLG AIASGLLLYG MSMIYGISGS LNINDIASFA
210 220 230 240 250
SNTNLDSRET LIINFGLVFL VIGIAFKLGA VPFHMWVPDV YQGAPTSVTL
260 270 280 290 300
FISTVPKIAA FAMLVRILVD GLDSMHAYWS DLFMVLSILS IALGSVVALM
310 320 330 340 350
QSNIKRMLAY STISHVGFIM LGFVAGTPIG YGAAAFYMLV YVLMSLAAFG
360 370 380 390 400
MIILLNKQGF EIDQISDFKG LNKHAPWFAL MMLIIILSMA GVPPLVGFYS
410 420 430 440 450
KFFILQQVVS AGFITIAVIV VIFAVISAYY YLQIIKSMYF DETDKKITIY
460 470 480
ASIDIQLVLS INAILILAVG LFPDFWMKLA LSLF
Length:484
Mass (Da):53,607
Last modified:January 23, 2007 - v1
Checksum:i9B9CCABC3F131AD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000488 Genomic DNA. Translation: ABL02032.1.
RefSeqiYP_903503.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL02032; ABL02032; Rmag_0250.
GeneIDi4555652.
KEGGirma:Rmag_0250.
PATRICi32000109. VBICanRut45856_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000488 Genomic DNA. Translation: ABL02032.1 .
RefSeqi YP_903503.1. NC_008610.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413404.Rmag_0250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL02032 ; ABL02032 ; Rmag_0250 .
GeneIDi 4555652.
KEGGi rma:Rmag_0250.
PATRICi 32000109. VBICanRut45856_0283.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100795.
KOi K00343.
OMAi IEAQLYG.
OrthoDBi EOG64JFNZ.

Enzyme and pathway databases

BioCyci CRUT413404:GHM7-259-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNUON_RUTMC
AccessioniPrimary (citable) accession number: A1AVS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3