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A1AVS5

- NUON_RUTMC

UniProt

A1AVS5 - NUON_RUTMC

Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciCRUT413404:GHM7-259-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit NUniRule annotation
    NDH-1 subunit NUniRule annotation
    Gene namesi
    Name:nuoNUniRule annotation
    Ordered Locus Names:Rmag_0250
    OrganismiRuthia magnifica subsp. Calyptogena magnifica
    Taxonomic identifieri413404 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
    ProteomesiUP000002587: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484NADH-quinone oxidoreductase subunit NPRO_0000391218Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi413404.Rmag_0250.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei79 – 9820HelicalUniRule annotationAdd
    BLAST
    Transmembranei113 – 13321HelicalUniRule annotationAdd
    BLAST
    Transmembranei134 – 15421HelicalUniRule annotationAdd
    BLAST
    Transmembranei167 – 18721HelicalUniRule annotationAdd
    BLAST
    Transmembranei211 – 23121HelicalUniRule annotationAdd
    BLAST
    Transmembranei248 – 26821HelicalUniRule annotationAdd
    BLAST
    Transmembranei279 – 29921HelicalUniRule annotationAdd
    BLAST
    Transmembranei313 – 33321HelicalUniRule annotationAdd
    BLAST
    Transmembranei335 – 35521HelicalUniRule annotationAdd
    BLAST
    Transmembranei378 – 39821HelicalUniRule annotationAdd
    BLAST
    Transmembranei408 – 42821HelicalUniRule annotationAdd
    BLAST
    Transmembranei457 – 47721HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000100795.
    KOiK00343.
    OMAiIEAQLYG.
    OrthoDBiEOG64JFNZ.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1AVS5-1 [UniParc]FASTAAdd to Basket

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    MNNFIEFDTS SLWIALPEIF LLSAIVIVLL IDLFLDKNFK QVTYYLIQLS    50
    LFITGLLAFN LIDHPQIIIF GGSFVLDNMA SVFKVFMMAA TMVAMVYSRH 100
    YLRTHSLFRG EYFVLVLLSV LGMMVMVSGY SLLTLYLGLE ILSLSLYALI 150
    AIARERADAI EAALKYFVLG AIASGLLLYG MSMIYGISGS LNINDIASFA 200
    SNTNLDSRET LIINFGLVFL VIGIAFKLGA VPFHMWVPDV YQGAPTSVTL 250
    FISTVPKIAA FAMLVRILVD GLDSMHAYWS DLFMVLSILS IALGSVVALM 300
    QSNIKRMLAY STISHVGFIM LGFVAGTPIG YGAAAFYMLV YVLMSLAAFG 350
    MIILLNKQGF EIDQISDFKG LNKHAPWFAL MMLIIILSMA GVPPLVGFYS 400
    KFFILQQVVS AGFITIAVIV VIFAVISAYY YLQIIKSMYF DETDKKITIY 450
    ASIDIQLVLS INAILILAVG LFPDFWMKLA LSLF 484
    Length:484
    Mass (Da):53,607
    Last modified:January 23, 2007 - v1
    Checksum:i9B9CCABC3F131AD9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000488 Genomic DNA. Translation: ABL02032.1.
    RefSeqiYP_903503.1. NC_008610.1.

    Genome annotation databases

    EnsemblBacteriaiABL02032; ABL02032; Rmag_0250.
    GeneIDi4555652.
    KEGGirma:Rmag_0250.
    PATRICi32000109. VBICanRut45856_0283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000488 Genomic DNA. Translation: ABL02032.1 .
    RefSeqi YP_903503.1. NC_008610.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 413404.Rmag_0250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL02032 ; ABL02032 ; Rmag_0250 .
    GeneIDi 4555652.
    KEGGi rma:Rmag_0250.
    PATRICi 32000109. VBICanRut45856_0283.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000100795.
    KOi K00343.
    OMAi IEAQLYG.
    OrthoDBi EOG64JFNZ.

    Enzyme and pathway databases

    BioCyci CRUT413404:GHM7-259-MONOMER.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNUON_RUTMC
    AccessioniPrimary (citable) accession number: A1AVS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3