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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:Rmag_0250
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbiontsCandidatus Ruthia
Proteomesi
  • UP000002587 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalUniRule annotationAdd BLAST21
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei79 – 98HelicalUniRule annotationAdd BLAST20
Transmembranei113 – 133HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei167 – 187HelicalUniRule annotationAdd BLAST21
Transmembranei211 – 231HelicalUniRule annotationAdd BLAST21
Transmembranei248 – 268HelicalUniRule annotationAdd BLAST21
Transmembranei279 – 299HelicalUniRule annotationAdd BLAST21
Transmembranei313 – 333HelicalUniRule annotationAdd BLAST21
Transmembranei335 – 355HelicalUniRule annotationAdd BLAST21
Transmembranei378 – 398HelicalUniRule annotationAdd BLAST21
Transmembranei408 – 428HelicalUniRule annotationAdd BLAST21
Transmembranei457 – 477HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003912181 – 484NADH-quinone oxidoreductase subunit NAdd BLAST484

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi413404.Rmag_0250.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000100795.
KOiK00343.
OMAiAYAMVIR.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AVS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFIEFDTS SLWIALPEIF LLSAIVIVLL IDLFLDKNFK QVTYYLIQLS
60 70 80 90 100
LFITGLLAFN LIDHPQIIIF GGSFVLDNMA SVFKVFMMAA TMVAMVYSRH
110 120 130 140 150
YLRTHSLFRG EYFVLVLLSV LGMMVMVSGY SLLTLYLGLE ILSLSLYALI
160 170 180 190 200
AIARERADAI EAALKYFVLG AIASGLLLYG MSMIYGISGS LNINDIASFA
210 220 230 240 250
SNTNLDSRET LIINFGLVFL VIGIAFKLGA VPFHMWVPDV YQGAPTSVTL
260 270 280 290 300
FISTVPKIAA FAMLVRILVD GLDSMHAYWS DLFMVLSILS IALGSVVALM
310 320 330 340 350
QSNIKRMLAY STISHVGFIM LGFVAGTPIG YGAAAFYMLV YVLMSLAAFG
360 370 380 390 400
MIILLNKQGF EIDQISDFKG LNKHAPWFAL MMLIIILSMA GVPPLVGFYS
410 420 430 440 450
KFFILQQVVS AGFITIAVIV VIFAVISAYY YLQIIKSMYF DETDKKITIY
460 470 480
ASIDIQLVLS INAILILAVG LFPDFWMKLA LSLF
Length:484
Mass (Da):53,607
Last modified:January 23, 2007 - v1
Checksum:i9B9CCABC3F131AD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000488 Genomic DNA. Translation: ABL02032.1.
RefSeqiWP_011737657.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL02032; ABL02032; Rmag_0250.
KEGGirma:Rmag_0250.
PATRICi32000109. VBICanRut45856_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000488 Genomic DNA. Translation: ABL02032.1.
RefSeqiWP_011737657.1. NC_008610.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi413404.Rmag_0250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL02032; ABL02032; Rmag_0250.
KEGGirma:Rmag_0250.
PATRICi32000109. VBICanRut45856_0283.

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000100795.
KOiK00343.
OMAiAYAMVIR.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNUON_RUTMC
AccessioniPrimary (citable) accession number: A1AVS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.