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A1AVQ1

- GSA_RUTMC

UniProt

A1AVQ1 - GSA_RUTMC

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, Rmag_0222
Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCRUT413404:GHM7-231-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Rmag_0222
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000002587: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000300943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi413404.Rmag_0222.

Structurei

3D structure databases

ProteinModelPortaliA1AVQ1.
SMRiA1AVQ1. Positions 2-423.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AVQ1-1 [UniParc]FASTAAdd to Basket

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MNQSETLFAQ AKTVIPGGVN SPVRAFNGVG GSPIFFTRGE GAYLFDEDDK    50
KYIDYVASWG SMILGHTNQA VIIAVKTTLE NGLGFGAPTQ IETKLAEKVC 100
ELMPSIELVR MVSSGTEATM SAIRLARGHT GRDKIIKFEG CYHGHSDSLL 150
IKAGSGALTL GVPTSPGVPK DFAKHTLTLE YNNIDQVCEV LSEVGAEVAC 200
IIVEPVAGNM NCIPPIDGFL QVLRELCDEY GVILVFDEVM TGFRVALGGA 250
QAFYNVKPDL TTLGKVIGGG LPVGAFGGKR EIMQSIAPLG PVYQAGTLSG 300
NPISMSAGLV MLNVLSKDEN FYTILNTKVQ KLTKGILAKA KENNIGMTAN 350
VVGGMFGLFF TDSQSVTNFK ETSQCNIELF KKFFHLMLAE GVYMAPSAYE 400
AGFVSSAHSD TDIQNTIDAA GRAFIKLT 428
Length:428
Mass (Da):45,699
Last modified:January 23, 2007 - v1
Checksum:i73FB004154C777A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL02008.1.
RefSeqiWP_011737633.1. NC_008610.1.
YP_903479.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL02008; ABL02008; Rmag_0222.
GeneIDi4554897.
KEGGirma:Rmag_0222.
PATRICi32000039. VBICanRut45856_0248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL02008.1 .
RefSeqi WP_011737633.1. NC_008610.1.
YP_903479.1. NC_008610.1.

3D structure databases

ProteinModelPortali A1AVQ1.
SMRi A1AVQ1. Positions 2-423.
ModBasei Search...

Protein-protein interaction databases

STRINGi 413404.Rmag_0222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL02008 ; ABL02008 ; Rmag_0222 .
GeneIDi 4554897.
KEGGi rma:Rmag_0222.
PATRICi 32000039. VBICanRut45856_0248.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci CRUT413404:GHM7-231-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGSA_RUTMC
AccessioniPrimary (citable) accession number: A1AVQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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