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A1AV52

- SYL_RUTMC

UniProt

A1AV52 - SYL_RUTMC

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Protein
Leucine--tRNA ligase
Gene
leuS, Rmag_0005
Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCRUT413404:GHM7-5-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Rmag_0005
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000002587: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 816816Leucine--tRNA ligaseUniRule annotation
PRO_1000009420Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi413404.Rmag_0005.

Structurei

3D structure databases

ProteinModelPortaliA1AV52.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi574 – 5785"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AV52-1 [UniParc]FASTAAdd to Basket

« Hide

MNSEYNAQKI EAQAQKYWQE NKSFEVSEDT SKEKYYCLSM FPYPSGSLHM    50
GHVRNYSIGD VISRYQKMQG KNVMQPIGWD GFGLPAENAA LENKVSPAKW 100
TYENIDYMRD QLSKLGFGYD WSREIATCHQ KYYRWEQWLF IKLFEKDLVY 150
KKNAIVNWDP VDQTVLANEQ VIDGRGWRSN ALIEKKKISQ WFMRITNYAD 200
ELIYGLDKLD GWPDAVKTMQ KNWIGKSVGL EVDFPRHNAD SIKVYTTRPD 250
TLMGVTYLVI SSEHPIALEA GKNNPQVQAF IDECKTIQIT KETMKTIDKK 300
GIDLGVKCIH PITSDDVPIW IANFVLIGYG TGAVMSVPAH DKRDYEFAKK 350
YGIAIKKVIN ENISIDKNAM TDKGVLFNSG EFNGLNFDQA FNEIAKTLTD 400
KNLGRKKTNY RLQDWGISRQ RYWGCPIPII NCQNCGIVVV PEADLPVVLP 450
EVMSFDSVGS LIKKMPEFYQ TTCPKCGKMA QQETDTLDTF FESSWYFARY 500
TCKDNNDKML DKRANYWLAN GGVDQYIGGI EHAILHLLYA RFFNKLLRDE 550
GFIKNDEPFK NLLTQGMVLK DGAKMSKSKG NTVDPAQMIE KYGADTVRLF 600
ILFAAPPTQN LEWSDSGLEG VHRFINKVYR LIMDFIQDHK SHAIGTLNNF 650
DKAQKDIRLK THQTLSKITD NMSRRYLFNT VIAALMKLCN TLSKFNDTSK 700
TSMAIRQESI HILLKTLSPI APHLCHYLWK KLGNIKAIIN EPWPNVDKSA 750
LVQDKMQIIV QVNGKLRTKL MFSTDVDNAQ IEAQTLANEN ITKFTKGKII 800
VKVIIVPNKL VNIVVK 816
Length:816
Mass (Da):93,408
Last modified:January 23, 2007 - v1
Checksum:iB464A5B928F544BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL01809.1.
RefSeqiYP_903280.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL01809; ABL01809; Rmag_0005.
GeneIDi4555501.
KEGGirma:Rmag_0005.
PATRICi31999537. VBICanRut45856_0005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL01809.1 .
RefSeqi YP_903280.1. NC_008610.1.

3D structure databases

ProteinModelPortali A1AV52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413404.Rmag_0005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL01809 ; ABL01809 ; Rmag_0005 .
GeneIDi 4555501.
KEGGi rma:Rmag_0005.
PATRICi 31999537. VBICanRut45856_0005.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CRUT413404:GHM7-5-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYL_RUTMC
AccessioniPrimary (citable) accession number: A1AV52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi