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A1AV52

- SYL_RUTMC

UniProt

A1AV52 - SYL_RUTMC

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCRUT413404:GHM7-5-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Rmag_0005
OrganismiRuthia magnifica subsp. Calyptogena magnifica
Taxonomic identifieri413404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbiontsCandidatus Ruthia
ProteomesiUP000002587: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 816816Leucine--tRNA ligasePRO_1000009420Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi413404.Rmag_0005.

Structurei

3D structure databases

ProteinModelPortaliA1AV52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi574 – 5785"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AV52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSEYNAQKI EAQAQKYWQE NKSFEVSEDT SKEKYYCLSM FPYPSGSLHM
60 70 80 90 100
GHVRNYSIGD VISRYQKMQG KNVMQPIGWD GFGLPAENAA LENKVSPAKW
110 120 130 140 150
TYENIDYMRD QLSKLGFGYD WSREIATCHQ KYYRWEQWLF IKLFEKDLVY
160 170 180 190 200
KKNAIVNWDP VDQTVLANEQ VIDGRGWRSN ALIEKKKISQ WFMRITNYAD
210 220 230 240 250
ELIYGLDKLD GWPDAVKTMQ KNWIGKSVGL EVDFPRHNAD SIKVYTTRPD
260 270 280 290 300
TLMGVTYLVI SSEHPIALEA GKNNPQVQAF IDECKTIQIT KETMKTIDKK
310 320 330 340 350
GIDLGVKCIH PITSDDVPIW IANFVLIGYG TGAVMSVPAH DKRDYEFAKK
360 370 380 390 400
YGIAIKKVIN ENISIDKNAM TDKGVLFNSG EFNGLNFDQA FNEIAKTLTD
410 420 430 440 450
KNLGRKKTNY RLQDWGISRQ RYWGCPIPII NCQNCGIVVV PEADLPVVLP
460 470 480 490 500
EVMSFDSVGS LIKKMPEFYQ TTCPKCGKMA QQETDTLDTF FESSWYFARY
510 520 530 540 550
TCKDNNDKML DKRANYWLAN GGVDQYIGGI EHAILHLLYA RFFNKLLRDE
560 570 580 590 600
GFIKNDEPFK NLLTQGMVLK DGAKMSKSKG NTVDPAQMIE KYGADTVRLF
610 620 630 640 650
ILFAAPPTQN LEWSDSGLEG VHRFINKVYR LIMDFIQDHK SHAIGTLNNF
660 670 680 690 700
DKAQKDIRLK THQTLSKITD NMSRRYLFNT VIAALMKLCN TLSKFNDTSK
710 720 730 740 750
TSMAIRQESI HILLKTLSPI APHLCHYLWK KLGNIKAIIN EPWPNVDKSA
760 770 780 790 800
LVQDKMQIIV QVNGKLRTKL MFSTDVDNAQ IEAQTLANEN ITKFTKGKII
810
VKVIIVPNKL VNIVVK
Length:816
Mass (Da):93,408
Last modified:January 23, 2007 - v1
Checksum:iB464A5B928F544BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL01809.1.
RefSeqiWP_011737435.1. NC_008610.1.
YP_903280.1. NC_008610.1.

Genome annotation databases

EnsemblBacteriaiABL01809; ABL01809; Rmag_0005.
GeneIDi4555501.
KEGGirma:Rmag_0005.
PATRICi31999537. VBICanRut45856_0005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000488 Genomic DNA. Translation: ABL01809.1 .
RefSeqi WP_011737435.1. NC_008610.1.
YP_903280.1. NC_008610.1.

3D structure databases

ProteinModelPortali A1AV52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413404.Rmag_0005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL01809 ; ABL01809 ; Rmag_0005 .
GeneIDi 4555501.
KEGGi rma:Rmag_0005.
PATRICi 31999537. VBICanRut45856_0005.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CRUT413404:GHM7-5-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYL_RUTMC
AccessioniPrimary (citable) accession number: A1AV52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3