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A1AV52

- SYL_RUTMC

UniProt

A1AV52 - SYL_RUTMC

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ruthia magnifica subsp. Calyptogena magnifica
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei577 – 5771ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCRUT413404:GHM7-5-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Rmag_0005
    OrganismiRuthia magnifica subsp. Calyptogena magnifica
    Taxonomic identifieri413404 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
    ProteomesiUP000002587: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 816816Leucine--tRNA ligasePRO_1000009420Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi413404.Rmag_0005.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AV52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi574 – 5785"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1AV52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSEYNAQKI EAQAQKYWQE NKSFEVSEDT SKEKYYCLSM FPYPSGSLHM    50
    GHVRNYSIGD VISRYQKMQG KNVMQPIGWD GFGLPAENAA LENKVSPAKW 100
    TYENIDYMRD QLSKLGFGYD WSREIATCHQ KYYRWEQWLF IKLFEKDLVY 150
    KKNAIVNWDP VDQTVLANEQ VIDGRGWRSN ALIEKKKISQ WFMRITNYAD 200
    ELIYGLDKLD GWPDAVKTMQ KNWIGKSVGL EVDFPRHNAD SIKVYTTRPD 250
    TLMGVTYLVI SSEHPIALEA GKNNPQVQAF IDECKTIQIT KETMKTIDKK 300
    GIDLGVKCIH PITSDDVPIW IANFVLIGYG TGAVMSVPAH DKRDYEFAKK 350
    YGIAIKKVIN ENISIDKNAM TDKGVLFNSG EFNGLNFDQA FNEIAKTLTD 400
    KNLGRKKTNY RLQDWGISRQ RYWGCPIPII NCQNCGIVVV PEADLPVVLP 450
    EVMSFDSVGS LIKKMPEFYQ TTCPKCGKMA QQETDTLDTF FESSWYFARY 500
    TCKDNNDKML DKRANYWLAN GGVDQYIGGI EHAILHLLYA RFFNKLLRDE 550
    GFIKNDEPFK NLLTQGMVLK DGAKMSKSKG NTVDPAQMIE KYGADTVRLF 600
    ILFAAPPTQN LEWSDSGLEG VHRFINKVYR LIMDFIQDHK SHAIGTLNNF 650
    DKAQKDIRLK THQTLSKITD NMSRRYLFNT VIAALMKLCN TLSKFNDTSK 700
    TSMAIRQESI HILLKTLSPI APHLCHYLWK KLGNIKAIIN EPWPNVDKSA 750
    LVQDKMQIIV QVNGKLRTKL MFSTDVDNAQ IEAQTLANEN ITKFTKGKII 800
    VKVIIVPNKL VNIVVK 816
    Length:816
    Mass (Da):93,408
    Last modified:January 23, 2007 - v1
    Checksum:iB464A5B928F544BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000488 Genomic DNA. Translation: ABL01809.1.
    RefSeqiYP_903280.1. NC_008610.1.

    Genome annotation databases

    EnsemblBacteriaiABL01809; ABL01809; Rmag_0005.
    GeneIDi4555501.
    KEGGirma:Rmag_0005.
    PATRICi31999537. VBICanRut45856_0005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000488 Genomic DNA. Translation: ABL01809.1 .
    RefSeqi YP_903280.1. NC_008610.1.

    3D structure databases

    ProteinModelPortali A1AV52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 413404.Rmag_0005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL01809 ; ABL01809 ; Rmag_0005 .
    GeneIDi 4555501.
    KEGGi rma:Rmag_0005.
    PATRICi 31999537. VBICanRut45856_0005.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CRUT413404:GHM7-5-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSYL_RUTMC
    AccessioniPrimary (citable) accession number: A1AV52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3