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Protein

Quinolinate synthase A

Gene

nadA

Organism
Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 231IminoaspartateUniRule annotation
Binding sitei40 – 401Iminoaspartate; via amide nitrogenUniRule annotation
Binding sitei111 – 1111IminoaspartateUniRule annotation
Binding sitei128 – 1281IminoaspartateUniRule annotation
Binding sitei197 – 1971IminoaspartateUniRule annotation
Binding sitei214 – 2141IminoaspartateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciPPRO338966:GHL0-3632-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:Ppro_3573
OrganismiPelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)
Taxonomic identifieri338966 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaePelobacter
Proteomesi
  • UP000006732 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Quinolinate synthase APRO_1000061162Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338966.Ppro_3573.

Structurei

3D structure databases

ProteinModelPortaliA1AUZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0I. Bacteria.
COG0379. LUCA.
HOGENOMiHOG000222770.
KOiK03517.
OMAiIAHPECE.
OrthoDBiPOG091H03D2.

Family and domain databases

HAMAPiMF_00568. NadA_type2. 1 hit.
InterProiIPR003473. NadA.
IPR023066. Quinolinate_synth_type2.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AUZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNGIKEQIR ELLKQHNAVL LAHNYMRDEV QEIADITGDS LALSIEAAKT
60 70 80 90 100
EADVIVFCGV HFMAESAAIL SPDKKVLLPR LDAGCPMADM VDARGLEELK
110 120 130 140 150
KKHPGVPVVT YVNSTAEVKA HSDICCTSAN ATRVVKSLPD KKVIFAPDRN
160 170 180 190 200
LGSFVAKSVP DKEFIFWDGY CPTHERMTVE AVLAKKTEYP EALFICHPEC
210 220 230 240 250
APAVTALADQ ACSTSAMYDY CRDSKARQFI IGTEAGILYR LRLENPDKEF
260 270 280 290 300
ILASPALFCP NMKLTSQEDV LHSLKTLTPV VSVPEDIRLK AKLALDRMLA

VPRD
Length:304
Mass (Da):33,545
Last modified:January 23, 2007 - v1
Checksum:i1486AA55AF10CB36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000482 Genomic DNA. Translation: ABL01165.1.
RefSeqiWP_011737378.1. NC_008609.1.

Genome annotation databases

EnsemblBacteriaiABL01165; ABL01165; Ppro_3573.
KEGGippd:Ppro_3573.
PATRICi22900279. VBIPelPro64470_3724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000482 Genomic DNA. Translation: ABL01165.1.
RefSeqiWP_011737378.1. NC_008609.1.

3D structure databases

ProteinModelPortaliA1AUZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338966.Ppro_3573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL01165; ABL01165; Ppro_3573.
KEGGippd:Ppro_3573.
PATRICi22900279. VBIPelPro64470_3724.

Phylogenomic databases

eggNOGiENOG4105D0I. Bacteria.
COG0379. LUCA.
HOGENOMiHOG000222770.
KOiK03517.
OMAiIAHPECE.
OrthoDBiPOG091H03D2.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327.
BioCyciPPRO338966:GHL0-3632-MONOMER.

Family and domain databases

HAMAPiMF_00568. NadA_type2. 1 hit.
InterProiIPR003473. NadA.
IPR023066. Quinolinate_synth_type2.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADA_PELPD
AccessioniPrimary (citable) accession number: A1AUZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.