A1AUT0 (PROA_PELPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	Ppro_3508

Organism

Pelobacter propionicus (strain DSM 2379) [Complete proteome] [HAMAP]

Taxonomic identifier

338966 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Pelobacteraceae › Pelobacter

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity HAMAP MF_00412.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_1000049974

Sequences

	Sequence		Length	Mass (Da)
	A1AUT0 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 20BD178FED153C1D	FASTA	418	45,618
	10 20 30 40 50 60 MTIAEQVAQI AHEARQASFV LSRLSTRVKN ELLLAMAEAL EQQAPHLIAE NAKDLEEGKQ 70 80 90 100 110 120 KGLSSAMLDR LMLDAKRISA MADALREVAA LPDPVGEVTK MWKRPNNLMV GKMRIPLGVI 130 140 150 160 170 180 GIIFEARPNV TADAAALCLK AGNAVILRGG KEAINSNRAI AAILREAMVS KGVPAGALAL 190 200 210 220 230 240 IPFTDRQGVL EMLKQEECID LIIPRGGEGL IRFVTENSRI PVIKHYKGVC HIFVDESADF 250 260 270 280 290 300 DMAERIIINA KTQRPGVCNA LETLLIHESV AAAFIPRIAS ILGGMQVELR GDERFRALAP 310 320 330 340 350 360 QAKPASEEDW YAEYLELILA CRVVDDLDQA IDHINRYGSL HTESIITSDY GRAQRFIREV 370 380 390 400 410 NSSCVVVNAS TRFADGNQLG LGAEIGISTT KLHSFGPMGL EDLTTTKFIV YGDGQVRE

References

[1]

"Complete sequence of chromosome of Pelobacter propionicus DSM 2379." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000482 Genomic DNA. Translation: ABL01101.1.
RefSeq	YP_903158.1. NC_008609.1.
3D structure databases
ProteinModelPortal	A1AUT0.
ModBase	Search...
Protein-protein interaction databases
STRING	A1AUT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4574357.
GenomeReviews	Gene locus Ppro_3508 in contig CP000482_GR.
KEGG	ppd:Ppro_3508.
PATRIC	22900161. VBIPelPro64470_3666.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0014.
HOGENOM	HBG318080.
OMA	YGICGAM.
PhylomeDB	A1AUT0.
ProtClustDB	PRK00197.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KO	K00147.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_PELPD

Accession

Primary (citable) accession number: A1AUT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program