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A1AU47

- GCH4_PELPD

UniProt

A1AU47 - GCH4_PELPD

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pelobacter propionicus (strain DSM 2379)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei144 – 1441May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPPRO338966:GHL0-3332-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Ppro_3275
    OrganismiPelobacter propionicus (strain DSM 2379)
    Taxonomic identifieri338966 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter
    ProteomesiUP000006732: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257GTP cyclohydrolase FolE2PRO_0000292755Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338966.Ppro_3275.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AU47.
    SMRiA1AU47. Positions 12-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1AU47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDMQKRPDH RRIPISKVGV KDISYPIVVM DKNRSLQHTV ARVNMYVDLP    50
    HQFKGTHMSR FVEILNRHRE QIALDKLETI LEEMKARLGS ASAHLEIQFP 100
    YFIDKRAPVS GARSLMEYSC EFSASLTDTL DFVLGVRVPL TSLCPCSREL 150
    AIHGAHNQRS IMTVRVRYRD FIWIEDLVEL IEQCGSSPLY SLLKRVDEKY 200
    VTEQAYENPR FVEDMVREAY SRLAGMENIT WFSVETENFE SIHNHSAYAA 250
    VELDRRG 257
    Length:257
    Mass (Da):29,794
    Last modified:June 26, 2007 - v2
    Checksum:i30774B6753A75E64
    GO

    Sequence cautioni

    The sequence ABL00868.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000482 Genomic DNA. Translation: ABL00868.1. Different initiation.
    RefSeqiYP_902925.1. NC_008609.1.

    Genome annotation databases

    EnsemblBacteriaiABL00868; ABL00868; Ppro_3275.
    GeneIDi4572269.
    KEGGippd:Ppro_3275.
    PATRICi22899689. VBIPelPro64470_3431.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000482 Genomic DNA. Translation: ABL00868.1 . Different initiation.
    RefSeqi YP_902925.1. NC_008609.1.

    3D structure databases

    ProteinModelPortali A1AU47.
    SMRi A1AU47. Positions 12-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338966.Ppro_3275.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL00868 ; ABL00868 ; Ppro_3275 .
    GeneIDi 4572269.
    KEGGi ppd:Ppro_3275.
    PATRICi 22899689. VBIPelPro64470_3431.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PPRO338966:GHL0-3332-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2379.

    Entry informationi

    Entry nameiGCH4_PELPD
    AccessioniPrimary (citable) accession number: A1AU47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3