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A1AU47

- GCH4_PELPD

UniProt

A1AU47 - GCH4_PELPD

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, Ppro_3275
Organism
Pelobacter propionicus (strain DSM 2379)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei144 – 1441May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPPRO338966:GHL0-3332-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Ppro_3275
OrganismiPelobacter propionicus (strain DSM 2379)
Taxonomic identifieri338966 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter
ProteomesiUP000006732: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257GTP cyclohydrolase FolE2UniRule annotation
PRO_0000292755Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338966.Ppro_3275.

Structurei

3D structure databases

ProteinModelPortaliA1AU47.
SMRiA1AU47. Positions 12-255.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AU47-1 [UniParc]FASTAAdd to Basket

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MPDMQKRPDH RRIPISKVGV KDISYPIVVM DKNRSLQHTV ARVNMYVDLP    50
HQFKGTHMSR FVEILNRHRE QIALDKLETI LEEMKARLGS ASAHLEIQFP 100
YFIDKRAPVS GARSLMEYSC EFSASLTDTL DFVLGVRVPL TSLCPCSREL 150
AIHGAHNQRS IMTVRVRYRD FIWIEDLVEL IEQCGSSPLY SLLKRVDEKY 200
VTEQAYENPR FVEDMVREAY SRLAGMENIT WFSVETENFE SIHNHSAYAA 250
VELDRRG 257
Length:257
Mass (Da):29,794
Last modified:June 26, 2007 - v2
Checksum:i30774B6753A75E64
GO

Sequence cautioni

The sequence ABL00868.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000482 Genomic DNA. Translation: ABL00868.1. Different initiation.
RefSeqiYP_902925.1. NC_008609.1.

Genome annotation databases

EnsemblBacteriaiABL00868; ABL00868; Ppro_3275.
GeneIDi4572269.
KEGGippd:Ppro_3275.
PATRICi22899689. VBIPelPro64470_3431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000482 Genomic DNA. Translation: ABL00868.1 . Different initiation.
RefSeqi YP_902925.1. NC_008609.1.

3D structure databases

ProteinModelPortali A1AU47.
SMRi A1AU47. Positions 12-255.
ModBasei Search...

Protein-protein interaction databases

STRINGi 338966.Ppro_3275.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL00868 ; ABL00868 ; Ppro_3275 .
GeneIDi 4572269.
KEGGi ppd:Ppro_3275.
PATRICi 22899689. VBIPelPro64470_3431.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PPRO338966:GHL0-3332-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2379.

Entry informationi

Entry nameiGCH4_PELPD
AccessioniPrimary (citable) accession number: A1AU47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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