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A1ATI0 (A1ATI0_PELPD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazole glycerol phosphate synthase subunit HisF HAMAP-Rule MF_01013
EC=4.1.3.- HAMAP-Rule MF_01013
Alternative name(s):
IGP synthase cyclase subunit HAMAP-Rule MF_01013
IGP synthase subunit HisF HAMAP-Rule MF_01013
ImGP synthase subunit HisF HAMAP-Rule MF_01013
Gene names
Name:hisF HAMAP-Rule MF_01013
Ordered Locus Names:Ppro_3055 EMBL ABL00651.1
OrganismPelobacter propionicus (strain DSM 2379) [Complete proteome] [HAMAP] EMBL ABL00651.1
Taxonomic identifier338966 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Pelobacteraceae › Pelobacter ›

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit By similarity. HAMAP-Rule MF_01013 SAAS SAAS004651

Catalytic activity

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O. HAMAP-Rule MF_01013 SAAS SAAS004651

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. HAMAP-Rule MF_01013 SAAS SAAS004651

Subunit structure

Heterodimer of HisH and HisF By similarity. HAMAP-Rule MF_01013 SAAS SAAS004651

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01013.

Sequence similarities

Belongs to the HisA/HisF family. RuleBase RU003657 HAMAP-Rule MF_01013

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site111 By similarity HAMAP-Rule MF_01013
Active site1301 By similarity HAMAP-Rule MF_01013

Sequences

Sequence LengthMass (Da)Tools
A1ATI0 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 4911FDD8866A6A1A

FASTA25327,699
        10         20         30         40         50         60 
MLTKRIIPCL DVKGGRVVKG VQFLELRDAG DPVEIAEIYD RQGADELTFL DITASSDERD 

        70         80         90        100        110        120 
IIIDVVRRTA ERVFMPLTVG GGIRTVQDIR RLLNAGADKT SINTAAVHRP EFVREAAERF 

       130        140        150        160        170        180 
GSQCTVVAID ARRVPGEKRW EVYTHGGRNP TGIDAVEWAV RMEEFGSGEI LLTSMDCDGT 

       190        200        210        220        230        240 
KDGYDLELTR AVVDAVSIPV IASGGVGNLE HLYDGFAQGG ASACLAASIF HYREYSIGEA 

       250 
KQYLKERGVP VRL

« Hide

References

[1]"Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2379 EMBL ABL00651.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000482 Genomic DNA. Translation: ABL00651.1.
RefSeqYP_902708.1. NC_008609.1.

3D structure databases

ProteinModelPortalA1ATI0.
SMRA1ATI0. Positions 2-253.
ModBaseSearch...

Protein-protein interaction databases

STRING338966.Ppro_3055.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL00651; ABL00651; Ppro_3055.
GeneID4574100.
KEGGppd:Ppro_3055.
PATRIC22899235. VBIPelPro64470_3208.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0107.
HOGENOMHOG000224612.
KOK02500.
OMARVVKGTN.
ProtClustDBPRK02083.

Enzyme and pathway databases

BioCycPPRO338966:GHL0-3116-MONOMER.
UniPathwayUPA00031; UER00010.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01013. HisF.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR004651. HisF.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00735. hisF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1ATI0_PELPD
AccessionPrimary (citable) accession number: A1ATI0
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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