A1ATG8 (A1ATG8_PELPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase 2 HAMAP MF_01023
EC=2.6.1.9 HAMAP MF_01023

Alternative name(s):
Imidazole acetol-phosphate transaminase 2 HAMAP MF_01023

Gene names

Name:	hisC2 HAMAP MF_01023
Ordered Locus Names:	Ppro_3041

Organism

Pelobacter propionicus (strain DSM 2379) [Complete proteome] [HAMAP]

Taxonomic identifier

338966 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Pelobacteraceae › Pelobacter

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023 SAAS SAAS005861
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023 SAAS SAAS005861
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023 SAAS SAAS005861
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. HAMAP MF_01023

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP MF_01023 SAAS SAAS005861
Ligand	Pyridoxal phosphate HAMAP MF_01023 SAAS SAAS005861
Molecular function	Aminotransferase HAMAP MF_01023 SAAS SAAS005861 EMBL ABL00639.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	212	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_01023

Sequences

	Sequence		Length	Mass (Da)
	A1ATG8 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: F7871C70295093D8	FASTA	350	39,093
	10 20 30 40 50 60 MMLLRSNIAS MQGYVPGYQP EDISSWIKLN TNENPYPPSP KVREAILAEM GDDGASLRTY 70 80 90 100 110 120 PSASSQRLRE AASELYGFDP SWIIMANGSD ELLNNLIRAC ASEGDEVGYV HPSYSYYATL 130 140 150 160 170 180 SEIQGAKVRT FGLTEDFRIA GFPDRYQGRV FFLTTPNAPL GFSFPLSYVE EIARSCQGLL 190 200 210 220 230 240 VIDEAYADFA DTNALELVRK YENVVVTRTF SKSYALAGMR LGLAIARPEI VAALDKIRDH 250 260 270 280 290 300 YNLDRLAQAS CIASLGDQEY FRQSCARIRE TREWFSAGLR SIGFSLIPSQ TNFVFASPPD 310 320 330 340 350 RNGRRVYDAL YSRKILVRHF SDPILAHGLR ISIGTRQEME LTLAALAEIA

References

[1]

"Complete sequence of chromosome of Pelobacter propionicus DSM 2379." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000482 Genomic DNA. Translation: ABL00639.1.
RefSeq	YP_902696.1. NC_008609.1.
3D structure databases
ProteinModelPortal	A1ATG8.
ModBase	Search...
Protein-protein interaction databases
STRING	A1ATG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4574296.
GenomeReviews	Gene locus Ppro_3041 in contig CP000482_GR.
KEGG	ppd:Ppro_3041.
PATRIC	22899203. VBIPelPro64470_3196.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	YVPGYQP.
ProtClustDB	CLSK829109.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1ATG8_PELPD

Accession

Primary (citable) accession number: A1ATG8

Entry history

Integrated into UniProtKB/TrEMBL:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)