A1ATF1 (A1ATF1_PELPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase HAMAP MF_00392
EC=2.4.1.182 HAMAP MF_00392

Gene names

Name:	lpxB HAMAP MF_00392
Ordered Locus Names:	Ppro_3024

Organism

Pelobacter propionicus (strain DSM 2379) [Complete proteome] [HAMAP]

Taxonomic identifier

338966 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Pelobacteraceae › Pelobacter

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392 SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392 SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392 SAAS SAAS003835
Sequence similarities	Belongs to the lpxB family. HAMAP MF_00392

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00392 SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase HAMAP MF_00392 SAAS SAAS003835 EMBL ABL00622.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1ATF1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 2F0D57A232EA6EF1	FASTA	379	41,397
	10 20 30 40 50 60 MSERRVMIVA GEASGDIYGA QLASETARLS PNIRFFGIGG ERMREAGVQT LVDSADMAVV 70 80 90 100 110 120 GLVEVLRHFD VIAKAFLKLK RILLQTPPHL LVLIDYPGFN LRLARVARRS GVRVLYYISP 130 140 150 160 170 180 QIWAWRQGRV HEIARLVDHM AVIFPFELPF YRNAGVAASF VGHPLYDLVA VEASRDQAAA 190 200 210 220 230 240 SFGLDPSRRI LGLFPGSRRS EVQRLLPVIV QAAALLKQCY PDLQLVLPLA STLGSEDIAP 250 260 270 280 290 300 HLPSDLPVTI TRDRIHDLIR GCDAIISVSG TVTLEIALLG TPMVVIYKLS PLTYQLARRL 310 320 330 340 350 360 VKVDNIALCN IVAGETVVRE LIQDDASANG IAAEIGTILD DDAYAGTIRA KLATVRSRLG 370 RGGAARNVAR LILEMVEQS

References

[1]

"Complete sequence of chromosome of Pelobacter propionicus DSM 2379." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000482 Genomic DNA. Translation: ABL00622.1.
RefSeq	YP_902679.1. NC_008609.1.
3D structure databases
ProteinModelPortal	A1ATF1.
ModBase	Search...
Protein-protein interaction databases
STRING	A1ATF1.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4574314.
GenomeReviews	Gene locus Ppro_3024 in contig CP000482_GR.
KEGG	ppd:Ppro_3024.
PATRIC	22899167. VBIPelPro64470_3178.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	AEFAFIC.
PhylomeDB	A1ATF1.
ProtClustDB	PRK00025.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1ATF1_PELPD

Accession

Primary (citable) accession number: A1ATF1

Entry history

Integrated into UniProtKB/TrEMBL:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)