Skip Header

Contribute Send feedback
Read comments (?) or add your own

A1ASJ7 (HEMH_PELPD) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Ppro_2715
OrganismPelobacter propionicus (strain DSM 2379) [Complete proteome] [HAMAP]
Taxonomic identifier338966 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Pelobacteraceae › Pelobacter

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Ferrochelatase HAMAP MF_00323
PRO_1000019333

Sites

Metal binding1931Iron By similarity
Metal binding2721Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A1ASJ7 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 33DFB71ECD20EDF3

FASTA32236,169
        10         20         30         40         50         60 
MVIDRTAVLL LQMGGPDSIE AVEPFLRNLF SDRDIIRIGP AFLQPLIARL IARRRSKRVA 

        70         80         90        100        110        120 
EQYRQIGGGS PLRKLTEQQA AELEKVLGEG YRCFVAMRYW KPDTSQALEA VVQAGITRIV 

       130        140        150        160        170        180 
ALSLYPHYSR ATSGSSFNEL ERVRARSATP FQVTCVRQFH DHPLYITSLC DRIGQALSGY 

       190        200        210        220        230        240 
ADPGDVHLLF TAHGLPQSFI DSGDPYLDQI RATVALVMER FGGINHHLAF QSRAGPVKWL 

       250        260        270        280        290        300 
EPSTEKKIRE LAGQGVKKLL MVPVSFVSDH IETLHEIDMQ YRHEALELGI EDFRRVESLN 

       310        320 
SSPLFIDCLA ELVRGGDRTE ET

« Hide

References

[1]"Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000482 Genomic DNA. Translation: ABL00318.1.
RefSeqYP_902375.1. NC_008609.1.

3D structure databases

ProteinModelPortalA1ASJ7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1ASJ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4573804.
GenomeReviewsGene locus Ppro_2715 in contig CP000482_GR.
KEGGppd:Ppro_2715.
PATRIC22898529. VBIPelPro64470_2862.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBA1ASJ7.
ProtClustDBCLSK790160.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_PELPD
AccessionPrimary (citable) accession number: A1ASJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents