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Protein

Alanine racemase

Gene

Ppro_2594

Organism
Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Ppro_2594)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei192SubstrateUniRule annotation1
Active sitei324Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei372Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPPRO338966:GHL0-2603-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Ppro_2594Imported
OrganismiPelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)Imported
Taxonomic identifieri338966 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaePelobacter
Proteomesi
  • UP000006732 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi338966.Ppro_2594

Structurei

3D structure databases

ProteinModelPortaliA1AS78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini303 – 432Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A1AS78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVERGGRGGA SNSQESLAFP IPDHLSPFPL FPFTAAKRHA NKRNWIYLPV
60 70 80 90 100
VRSFALLYDS RPTFAEIDLS ALRHNFQLIR SSVSPQAELL AVVKADAYGH
110 120 130 140 150
GFMDISRELE RLGVNAFGVA FLAEAIQLRK AGIDRPILLL GGVYPGQERK
160 170 180 190 200
CIGYNISTIV FNLEQARALD RAAAKLFRKA QLHLKVDTGM GRLGIPYAEV
210 220 230 240 250
PSFLRELAAL PHISLEGVVS HFASADELNE SGRYFSRLQA ERFAWALAET
260 270 280 290 300
RSAGFAPRYV HIANSAAGLL RDIPGCNLVR PGIALYGALP SPDFQGQLDL
310 320 330 340 350
RPVMRLKSRI AMLKWVEPGT PISYGRRFTT GGRTLIASVP VGYADGYVRA
360 370 380 390 400
LTNRGEALVR GERARVAGTV CMDWIMLDVT GVKGVSVGDP VVLMGPDDSG
410 420 430
NCIHAEELAE AAGTIPYEIF CGISKRVPRV YLS
Length:433
Mass (Da):47,276
Last modified:January 23, 2007 - v1
Checksum:i7C629D59050D1FB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000482 Genomic DNA Translation: ABL00199.1
RefSeqiWP_011736452.1, NC_008609.1

Genome annotation databases

EnsemblBacteriaiABL00199; ABL00199; Ppro_2594
KEGGippd:Ppro_2594

Similar proteinsi

Entry informationi

Entry nameiA1AS78_PELPD
AccessioniPrimary (citable) accession number: A1AS78
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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