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A1AS75 (A1AS75_PELPD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:Ppro_2591 EMBL ABL00196.1
OrganismPelobacter propionicus (strain DSM 2379) [Complete proteome] [HAMAP] EMBL ABL00196.1
Taxonomic identifier338966 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Pelobacteraceae › Pelobacter ›

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain107 – 313207ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding133 – 19462ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2831Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2851Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
A1AS75 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 8B88FFC8A3CD513F

FASTA42344,812
        10         20         30         40         50         60 
MKILVVGGGG REHALVWKIA QSPLVKKVYC APGNPGTAGL AENLPIRADE VGKLLEFAWN 

        70         80         90        100        110        120 
EGIDLTVVGP EQPLSLGIVD TFENHDLKIF GPHQQAALIE GSKAFSKDLM RKYNVPTAAY 

       130        140        150        160        170        180 
GVFSDIGEAE AFIDRTGLPI VIKADGLAAG KGVIIAQTRQ EAVDTVTDML SGNAFGSAGS 

       190        200        210        220        230        240 
RVVIEEFLTG EEASFLAITD GKNIIPLASA QDHKAIFDGD QGPNTGGMGA YSPAPVVTRE 

       250        260        270        280        290        300 
IHEIAMRDVL RPTVDGMAAE GRPYRGVLYA GLMVKDGKVK TLEFNARFGD PECQPLLMRM 

       310        320        330        340        350        360 
KSDIVPLLLA AASGDISGMD IEWHDRAAVC VVMAAEGYPG EYRKGDAISG LADAAKLDDV 

       370        380        390        400        410        420 
YVFHAGTAQD GGRCVTNGGR VLGVTAMDDT VEQAIARAYQ AASVISWPGV QFRTDIGRKA 


IGR

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References

[1]"Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2379 EMBL ABL00196.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000482 Genomic DNA. Translation: ABL00196.1.
RefSeqYP_902253.1. NC_008609.1.

3D structure databases

ProteinModelPortalA1AS75.
SMRA1AS75. Positions 1-423.
ModBaseSearch...

Protein-protein interaction databases

STRING338966.Ppro_2591.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL00196; ABL00196; Ppro_2591.
GeneID4572700.
KEGGppd:Ppro_2591.
PATRIC22898279. VBIPelPro64470_2745.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMAMGAYTPL.
ProtClustDBPRK00885.

Enzyme and pathway databases

BioCycPPRO338966:GHL0-2654-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1AS75_PELPD
AccessionPrimary (citable) accession number: A1AS75
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info