A1AR95 (ACPS_PELPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS

Gene names

Name:	acpS
Ordered Locus Names:	Ppro_2258

Organism

Pelobacter propionicus (strain DSM 2379) [Complete proteome] [HAMAP]

Taxonomic identifier

338966 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Pelobacteraceae › Pelobacter

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101
Cofactor	Magnesium By similarity. HAMAP MF_00101
Subcellular location	Cytoplasm By similarity HAMAP MF_00101.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Holo-[acyl-carrier-protein] synthase HAMAP MF_00101		PRO_1000008471
Sites
	Metal binding	8	1	Magnesium By similarity
	Metal binding	58	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1AR95 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 20F7009FCA9AE2CD	FASTA	127	13,912
	10 20 30 40 50 60 MIIGIGTDIV GIPRFQRHVD DPDSSLLRRI FTDQERSYCN ARKSGAAACF AARFAAKESF 70 80 90 100 110 120 LKALGTGLSD GISWHDMEVV NDELGKPELR LSRRAEELFR KKKGAGLFLS LSHDGGCAVA MVVLESL

References

[1]

"Complete sequence of chromosome of Pelobacter propionicus DSM 2379." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000482 Genomic DNA. Translation: ABK99865.1.
RefSeq	YP_901923.1. NC_008609.1.
3D structure databases
ProteinModelPortal	A1AR95.
ModBase	Search...
Protein-protein interaction databases
STRING	A1AR95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4574982.
GenomeReviews	Gene locus Ppro_2258 in contig CP000482_GR.
KEGG	ppd:Ppro_2258.
PATRIC	22897585. VBIPelPro64470_2397.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0736.
HOGENOM	HBG734479.
OMA	NSSAIAY.
PhylomeDB	A1AR95.
ProtClustDB	PRK14656.
Family and domain databases
HAMAP	MF_00101. AcpS. [Tree]
InterPro	IPR008278. 4-PPantetheinyl_Trfase. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase. [Graphical view]
Gene3D	G3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KO	K00997.
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. AcpS. 1 hit. TIGR00556. Pantethn_trn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACPS_PELPD

Accession

Primary (citable) accession number: A1AR95

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program