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A1APS3

- SYL_PELPD

UniProt

A1APS3 - SYL_PELPD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pelobacter propionicus (strain DSM 2379)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPRO338966:GHL0-1763-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Ppro_1731
    OrganismiPelobacter propionicus (strain DSM 2379)
    Taxonomic identifieri338966 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter
    ProteomesiUP000006732: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 823823Leucine--tRNA ligasePRO_1000009389Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338966.Ppro_1731.

    Structurei

    3D structure databases

    ProteinModelPortaliA1APS3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1APS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQKYNPAAV EQKWQQQWET GASFAVNEQS DRPKYYLLEM FPYPSGRIHM    50
    GHVRNYSIGD VIGRFKRMRG FNVLHPMGWD AFGMPAENAA IQNKSHPAKW 100
    TYENIDYMRG QLKKMGLSYD WGRELATCDL EYYRWEQKIF LEMFAKGLAY 150
    KKTSYVNWCP TCETVLANEQ VEDGACWRCD SPVQQKELDQ WFFRITQYAE 200
    ELLSYTEKLP GWPERVLVMQ KNWIGKSHGC EVDFPLEGGT GSVRVFTTRP 250
    DTLFGATFMS LAPEHPQARE LTTPDRRDEV ERFIEKVRNT DRSKRTADDY 300
    EKEGVFTGSY CINPLTQVRM PIYLANFVLT DYGTGAVMAV PTHDQRDFEF 350
    AKKYGLDLKV VIQPEGTTLD PATMEAAYTE PGIMVNSGTF DGMGSEEAKQ 400
    AIADHLQEMG GGTKTVTYRL RDWGISRQRY WGNPIPVIYC DCCGVVPVPE 450
    KDLPVRLPMD VEFTGEGGSP LARLESFINV PCPTCGKPAR RETDTMDTFV 500
    QSSWYFLRYC CPDFHDAPLD RTRVDYWMSV DQYIGGIEHA VLHLLYARFF 550
    TKVLRDLGYV ECSEPFTNLL TQGMVIKDGA KMSKSKGNVV DPNALIERYG 600
    ADTARLFSLF AAPPEKDLDW NDQGVDGSFR FLNRVWKLVN DRLELISGAA 650
    PLDVPGLTGE ERTLRRAVHK TIRKVTEDIE GRFHFNTAIA AVMELLNVLQ 700
    SADLSTPQAG AVMKEALESL VLLLAPFVPH MAEELWQRMG QPGALSTTPW 750
    PEYDREAAVD DEVLMVVQVN GKLRSKITVA AGSDEESLKA LALADDKVQP 800
    FLQGVQVRKV ICVKGKLVNI VVG 823
    Length:823
    Mass (Da):93,197
    Last modified:January 23, 2007 - v1
    Checksum:iCAB6CCB2970CA526
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000482 Genomic DNA. Translation: ABK99343.1.
    RefSeqiYP_901401.1. NC_008609.1.

    Genome annotation databases

    EnsemblBacteriaiABK99343; ABK99343; Ppro_1731.
    GeneIDi4572832.
    KEGGippd:Ppro_1731.
    PATRICi22896557. VBIPelPro64470_1887.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000482 Genomic DNA. Translation: ABK99343.1 .
    RefSeqi YP_901401.1. NC_008609.1.

    3D structure databases

    ProteinModelPortali A1APS3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338966.Ppro_1731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK99343 ; ABK99343 ; Ppro_1731 .
    GeneIDi 4572832.
    KEGGi ppd:Ppro_1731.
    PATRICi 22896557. VBIPelPro64470_1887.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PPRO338966:GHL0-1763-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2379.

    Entry informationi

    Entry nameiSYL_PELPD
    AccessioniPrimary (citable) accession number: A1APS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3