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A1APM0

- PYRF_PELPD

UniProt

A1APM0 - PYRF_PELPD

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Pelobacter propionicus (strain DSM 2379)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151SubstrateUniRule annotation
    Binding sitei37 – 371SubstrateUniRule annotation
    Active sitei66 – 661Proton donorUniRule annotation
    Binding sitei125 – 1251SubstrateUniRule annotation
    Binding sitei186 – 1861SubstrateUniRule annotation
    Binding sitei195 – 1951SubstrateUniRule annotation
    Binding sitei215 – 2151Substrate; via amide nitrogenUniRule annotation
    Binding sitei216 – 2161SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciPPRO338966:GHL0-1702-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:Ppro_1676
    OrganismiPelobacter propionicus (strain DSM 2379)
    Taxonomic identifieri338966 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter
    ProteomesiUP000006732: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Orotidine 5'-phosphate decarboxylasePRO_1000065925Add
    BLAST

    Proteomic databases

    PRIDEiA1APM0.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi338966.Ppro_1676.

    Structurei

    3D structure databases

    ProteinModelPortaliA1APM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni64 – 7310Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226070.
    KOiK01591.
    OMAiRPITQSA.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1APM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRDEARKKI IFALDVNGIA EIDRYAGLLS DRVGMFKIGK ELFTACGPEA    50
    VATVRRHGGQ VFLDLKYHDI PNTVAKAMLE AARLGVQLAN LHALGGLEMM 100
    ETAASAVRRE FGDDRPRLLA VTILTSSTAE TLRRVGIDHP VEEMVVRLAC 150
    LAREAGMDGV VASPREIGLI RQACGPDFLI VTPGVRPSFA SQDDQKRIMS 200
    PDDAVREGAD YLVIGRPIAK ADDPVRAVDM IVDEIVAGCP 240
    Length:240
    Mass (Da):25,989
    Last modified:January 23, 2007 - v1
    Checksum:i56341B2BADFEBE13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000482 Genomic DNA. Translation: ABK99290.1.
    RefSeqiWP_011735567.1. NC_008609.1.
    YP_901348.1. NC_008609.1.

    Genome annotation databases

    EnsemblBacteriaiABK99290; ABK99290; Ppro_1676.
    GeneIDi4572627.
    KEGGippd:Ppro_1676.
    PATRICi22896439. VBIPelPro64470_1835.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000482 Genomic DNA. Translation: ABK99290.1 .
    RefSeqi WP_011735567.1. NC_008609.1.
    YP_901348.1. NC_008609.1.

    3D structure databases

    ProteinModelPortali A1APM0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338966.Ppro_1676.

    Proteomic databases

    PRIDEi A1APM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK99290 ; ABK99290 ; Ppro_1676 .
    GeneIDi 4572627.
    KEGGi ppd:Ppro_1676.
    PATRICi 22896439. VBIPelPro64470_1835.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226070.
    KOi K01591.
    OMAi RPITQSA.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci PPRO338966:GHL0-1702-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2379.

    Entry informationi

    Entry nameiPYRF_PELPD
    AccessioniPrimary (citable) accession number: A1APM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3