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A1ALQ2 (NUON_PELPD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit N

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit N
NDH-1 subunit N
Gene names
Name:nuoN
Ordered Locus Names:Ppro_0641
OrganismPelobacter propionicus (strain DSM 2379) [Complete proteome] [HAMAP]
Taxonomic identifier338966 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00445

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_00445

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00445.

Sequence similarities

Belongs to the complex I subunit 2 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463NADH-quinone oxidoreductase subunit N HAMAP-Rule MF_00445
PRO_0000391201

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane34 – 5421Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane259 – 27921Helical; Potential
Transmembrane286 – 30318Helical; Potential
Transmembrane314 – 33421Helical; Potential
Transmembrane356 – 37621Helical; Potential
Transmembrane393 – 41321Helical; Potential
Transmembrane432 – 45221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1ALQ2 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 83B7BA884BE83ABB

FASTA46349,096
        10         20         30         40         50         60 
MATDLLYGLL PEHILLGLIL VLMLLEILSV DKRAGSALFI ASLLAGAGVL VMQLQTGYTA 

        70         80         90        100        110        120 
DIVMNEIRID RFSEIGRLII VSCGAILGVY SLSSEAGHKY WILIASSLLG AMIILDSAGF 

       130        140        150        160        170        180 
ISLFMGIEIL SLPGFALMVL NNGKSTASEG SIKYLLLSSV ATALVLFGLS LVYGSTGNLN 

       190        200        210        220        230        240 
ISSFTAAVAT GGVQNLAASV MILSGFFLKA SVFPFHGWAP DAYSSARLPV TAFLASIVKA 

       250        260        270        280        290        300 
AVVLGLVRIL GNAVLNPEAV TVIALLSMLS MFYGNITAIH QTAFKKMLAY SSISHAGYMM 

       310        320        330        340        350        360 
FALVDNTGAR TEALLYYVAV YAVTTITACA CFSILSGEDD NLDNLNGIFR KKPVAAILLS 

       370        380        390        400        410        420 
LCVLSLAGIP PLPGFLAKFF VFKTVIASGH LTVAVLAFVA SYIGTFFYLG VVLRMFRSDA 

       430        440        450        460 
ETVEQPANAT CLCWTWGGAL LGTLALALFM LLPNIFHWVM TGI 

« Hide

References

[1]"Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000482 Genomic DNA. Translation: ABK98272.1.
RefSeqYP_900330.1. NC_008609.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338966.Ppro_0641.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK98272; ABK98272; Ppro_0641.
GeneID4571818.
KEGGppd:Ppro_0641.
PATRIC22894315. VBIPelPro64470_0795.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1007.
HOGENOMHOG000129655.
KOK00343.
OMAFMPKWLI.
OrthoDBEOG64JFNZ.
ProtClustDBCLSK781338.

Enzyme and pathway databases

BioCycPPRO338966:GHL0-646-MONOMER.

Family and domain databases

HAMAPMF_00445. NDH1_NuoN_1.
InterProIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUON_PELPD
AccessionPrimary (citable) accession number: A1ALQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families