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A1ALQ2

- NUON_PELPD

UniProt

A1ALQ2 - NUON_PELPD

Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Pelobacter propionicus (strain DSM 2379)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciPPRO338966:GHL0-646-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit NUniRule annotation
    NDH-1 subunit NUniRule annotation
    Gene namesi
    Name:nuoNUniRule annotation
    Ordered Locus Names:Ppro_0641
    OrganismiPelobacter propionicus (strain DSM 2379)
    Taxonomic identifieri338966 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter
    ProteomesiUP000006732: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463NADH-quinone oxidoreductase subunit NPRO_0000391201Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi338966.Ppro_0641.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalUniRule annotationAdd
    BLAST
    Transmembranei34 – 5421HelicalUniRule annotationAdd
    BLAST
    Transmembranei72 – 9221HelicalUniRule annotationAdd
    BLAST
    Transmembranei99 – 11921HelicalUniRule annotationAdd
    BLAST
    Transmembranei120 – 14021HelicalUniRule annotationAdd
    BLAST
    Transmembranei154 – 17421HelicalUniRule annotationAdd
    BLAST
    Transmembranei196 – 21621HelicalUniRule annotationAdd
    BLAST
    Transmembranei230 – 25021HelicalUniRule annotationAdd
    BLAST
    Transmembranei259 – 27921HelicalUniRule annotationAdd
    BLAST
    Transmembranei286 – 30318HelicalUniRule annotationAdd
    BLAST
    Transmembranei314 – 33421HelicalUniRule annotationAdd
    BLAST
    Transmembranei356 – 37621HelicalUniRule annotationAdd
    BLAST
    Transmembranei393 – 41321HelicalUniRule annotationAdd
    BLAST
    Transmembranei432 – 45221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000129655.
    KOiK00343.
    OMAiEATTKYF.
    OrthoDBiEOG64JFNZ.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1ALQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATDLLYGLL PEHILLGLIL VLMLLEILSV DKRAGSALFI ASLLAGAGVL    50
    VMQLQTGYTA DIVMNEIRID RFSEIGRLII VSCGAILGVY SLSSEAGHKY 100
    WILIASSLLG AMIILDSAGF ISLFMGIEIL SLPGFALMVL NNGKSTASEG 150
    SIKYLLLSSV ATALVLFGLS LVYGSTGNLN ISSFTAAVAT GGVQNLAASV 200
    MILSGFFLKA SVFPFHGWAP DAYSSARLPV TAFLASIVKA AVVLGLVRIL 250
    GNAVLNPEAV TVIALLSMLS MFYGNITAIH QTAFKKMLAY SSISHAGYMM 300
    FALVDNTGAR TEALLYYVAV YAVTTITACA CFSILSGEDD NLDNLNGIFR 350
    KKPVAAILLS LCVLSLAGIP PLPGFLAKFF VFKTVIASGH LTVAVLAFVA 400
    SYIGTFFYLG VVLRMFRSDA ETVEQPANAT CLCWTWGGAL LGTLALALFM 450
    LLPNIFHWVM TGI 463
    Length:463
    Mass (Da):49,096
    Last modified:January 23, 2007 - v1
    Checksum:i83B7BA884BE83ABB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000482 Genomic DNA. Translation: ABK98272.1.
    RefSeqiWP_011734585.1. NC_008609.1.
    YP_900330.1. NC_008609.1.

    Genome annotation databases

    EnsemblBacteriaiABK98272; ABK98272; Ppro_0641.
    GeneIDi4571818.
    KEGGippd:Ppro_0641.
    PATRICi22894315. VBIPelPro64470_0795.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000482 Genomic DNA. Translation: ABK98272.1 .
    RefSeqi WP_011734585.1. NC_008609.1.
    YP_900330.1. NC_008609.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338966.Ppro_0641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK98272 ; ABK98272 ; Ppro_0641 .
    GeneIDi 4571818.
    KEGGi ppd:Ppro_0641.
    PATRICi 22894315. VBIPelPro64470_0795.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000129655.
    KOi K00343.
    OMAi EATTKYF.
    OrthoDBi EOG64JFNZ.

    Enzyme and pathway databases

    BioCyci PPRO338966:GHL0-646-MONOMER.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Pelobacter propionicus DSM 2379."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Lovley D., Richardson P.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2379.

    Entry informationi

    Entry nameiNUON_PELPD
    AccessioniPrimary (citable) accession number: A1ALQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3