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Reviewed, UniProtKB/Swiss-Prot A1AJU8 (DEOC_ECOK1)

Last modified June 16, 2009. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA
Gene names
Name: deoC
Ordered Locus Names: Ecok1_44440
ORF Names: APECO1_2000
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592

Pathway

Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the deoC/fbaB aldolase family. DeoC type 2 subfamily.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate catabolic process

Inferred from electronic annotation. Source: HAMAP

deoxyribonucleotide catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondeoxyribose-phosphate aldolase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Deoxyribose-phosphate aldolase HAMAP MF_00592
PRO_1000072596

Sites

Active site1671Schiff-base intermediate with acetaldehyde By similarity
Active site2011 By similarity

Amino acid modifications

Modified residue1671N6-acetyllysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
A1AJU8-1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 3D6F46383DE40F52

FASTA25927,760
        10         20         30         40         50         60 
MTDLKASSLR ALKLMDLTTL NDDDTDEKVI ALCHQAKTPV GNTAAICIYP RFIPIARKTL 

        70         80         90        100        110        120 
KEQGTPEIRI ATVTNFPHGN DDIEIALAET RAAIAYGADE VDVVFPYRAL MAGNEQVGFD 

       130        140        150        160        170        180 
LVKACKEACA AANVLLKVII ETGELKDEAL IRKASEISIK AGADFIKTST GKVAVNATPE 

       190        200        210        220        230        240 
SARIMMEVIR DMGVEKIVGF KPAGGVRTAE DAQKYLAIAD ELFGADWADA RHYRFGASSL 

       250 
LASLLKALGH GDGKSASSY

« Hide

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References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed: 17293413] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000468 Genomic DNA. Translation: ABJ03938.1.
RefSeqYP_860062.1.

3D structure databases

SMRA1AJU8. Positions 1-251.
ModBaseSearch...

Genome annotation databases

GeneID4491976.
GenomeReviewsGene locus Ecok1_44440 in contig CP000468_GR.
KEGGecv:APECO1_2000.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAA1AJU8. CKEACGD.

Family and domain databases

HAMAPMF_00592.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/AroFGH_arch.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR10889. DeoC. 1 hit.
PfamPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFPIRSF001357. DeoC. 1 hit.
TIGRFAMsTIGR00126. deoC. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameDEOC_ECOK1
AccessionPrimary (citable) accession number: A1AJU8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents