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Protein

HTH-type transcriptional repressor FabR

Gene

fabR

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. negative regulation of fatty acid biosynthetic process Source: UniProtKB-HAMAP
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor FabRUniRule annotation
Gene namesi
Name:fabRUniRule annotation
Ordered Locus Names:Ecok1_39410
ORF Names:APECO1_2500
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215HTH-type transcriptional repressor FabRPRO_0000293567Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi405955.APECO1_2500.

Structurei

3D structure databases

ProteinModelPortaliA1AIE5.
SMRiA1AIE5. Positions 8-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7061HTH tetR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000270364.
OrthoDBiEOG6ZPT09.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_01190. HTH_type_FabR.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR023764. Tscrpt_reg_HTH_FabR.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AIE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR
60 70 80 90 100
HFRDVDELGL TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG
110 120 130 140 150
NNPNAFRLLL RERSGTSAAF RAAVAREIQH FIAELADYLE LENHMPRAFT
160 170 180 190 200
EAQAEAMVTI VFSAGAEALD VGVEQRRQLE ERLVLQLRMI SKGAYYWYRR
210
EQEKTTIIPG NVKDE
Length:215
Mass (Da):24,434
Last modified:July 10, 2007 - v2
Checksum:iACB9729EA947E256
GO

Sequence cautioni

The sequence ABJ03435.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ03435.1. Different initiation.
RefSeqiYP_859559.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ03435; ABJ03435; APECO1_2500.
GeneIDi4491447.
KEGGiecv:APECO1_2500.
PATRICi18220461. VBIEscCol127180_4440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ03435.1. Different initiation.
RefSeqiYP_859559.1. NC_008563.1.

3D structure databases

ProteinModelPortaliA1AIE5.
SMRiA1AIE5. Positions 8-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405955.APECO1_2500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ03435; ABJ03435; APECO1_2500.
GeneIDi4491447.
KEGGiecv:APECO1_2500.
PATRICi18220461. VBIEscCol127180_4440.

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000270364.
OrthoDBiEOG6ZPT09.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_01190. HTH_type_FabR.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR023764. Tscrpt_reg_HTH_FabR.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFABR_ECOK1
AccessioniPrimary (citable) accession number: A1AIE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: January 7, 2015
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.