A1AIE5 (FABR_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional repressor FabR

Gene names

Name:	fabR
Ordered Locus Names:	Ecok1_39410
ORF Names:	APECO1_2500

Organism

Escherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]

Taxonomic identifier

405955 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer By similarity. HAMAP-Rule MF_01190
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 HTH tetR-type DNA-binding domain.
Sequence caution	The sequence ABJ03435.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Transcription Transcription regulation
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP negative regulation of fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	HTH-type transcriptional repressor FabR HAMAP-Rule MF_01190		PRO_0000293567
Regions
	Domain	10 – 70	61	HTH tetR-type
	DNA binding	33 – 52	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1AIE5 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: ACB9729EA947E256	FASTA	215	24,434
	10 20 30 40 50 60 MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR HFRDVDELGL 70 80 90 100 110 120 TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG NNPNAFRLLL RERSGTSAAF 130 140 150 160 170 180 RAAVAREIQH FIAELADYLE LENHMPRAFT EAQAEAMVTI VFSAGAEALD VGVEQRRQLE 190 200 210 ERLVLQLRMI SKGAYYWYRR EQEKTTIIPG NVKDE

References

[1]

"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes." Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K. J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000468 Genomic DNA. Translation: ABJ03435.1. Different initiation.
RefSeq	YP_859559.1. NC_008563.1.
3D structure databases
ProteinModelPortal	A1AIE5.
SMR	A1AIE5. Positions 8-195.
ModBase	Search...
Protein-protein interaction databases
STRING	405955.APECO1_2500.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ03435; ABJ03435; APECO1_2500.
GeneID	4491447.
KEGG	ecv:APECO1_2500.
PATRIC	18220461. VBIEscCol127180_4440.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1309.
HOGENOM	HOG000270364.
ProtClustDB	PRK11202.
Family and domain databases
Gene3D	1.10.357.10. 1 hit.
HAMAP	MF_01190. HTH-type_FabR.
InterPro	IPR009057. Homeodomain-like. IPR001647. HTH_TetR. IPR015893. Tet_transcr_reg_TetR-like_C. IPR023764. Tscrpt_reg_HTH_FabR. [Graphical view]
Pfam	PF00440. TetR_N. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS01081. HTH_TETR_1. False negative. PS50977. HTH_TETR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABR_ECOK1

Accession

Primary (citable) accession number: A1AIE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program