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A1AIE5 (FABR_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional repressor FabR
Gene names
Name:fabR
Ordered Locus Names:Ecok1_39410
ORF Names:APECO1_2500
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer By similarity. HAMAP-Rule MF_01190

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01190

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01190.

Sequence similarities

Contains 1 HTH tetR-type DNA-binding domain.

Sequence caution

The sequence ABJ03435.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215HTH-type transcriptional repressor FabR HAMAP-Rule MF_01190
PRO_0000293567

Regions

Domain10 – 7061HTH tetR-type
DNA binding33 – 5220H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
A1AIE5 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: ACB9729EA947E256

FASTA21524,434
        10         20         30         40         50         60 
MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR HFRDVDELGL 

        70         80         90        100        110        120 
TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG NNPNAFRLLL RERSGTSAAF 

       130        140        150        160        170        180 
RAAVAREIQH FIAELADYLE LENHMPRAFT EAQAEAMVTI VFSAGAEALD VGVEQRRQLE 

       190        200        210 
ERLVLQLRMI SKGAYYWYRR EQEKTTIIPG NVKDE 

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000468 Genomic DNA. Translation: ABJ03435.1. Different initiation.
RefSeqYP_859559.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1AIE5.
SMRA1AIE5. Positions 8-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405955.APECO1_2500.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ03435; ABJ03435; APECO1_2500.
GeneID4491447.
KEGGecv:APECO1_2500.
PATRIC18220461. VBIEscCol127180_4440.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1309.
HOGENOMHOG000270364.
OrthoDBEOG6ZPT09.
ProtClustDBPRK11202.

Family and domain databases

Gene3D1.10.357.10. 1 hit.
HAMAPMF_01190. HTH_type_FabR.
InterProIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR023764. Tscrpt_reg_HTH_FabR.
[Graphical view]
PfamPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABR_ECOK1
AccessionPrimary (citable) accession number: A1AIE5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families