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A1AIE5

- FABR_ECOK1

UniProt

A1AIE5 - FABR_ECOK1

Protein

HTH-type transcriptional repressor FabR

Gene

fabR

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi33 – 5220H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
    2. negative regulation of fatty acid biosynthetic process Source: UniProtKB-HAMAP
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional repressor FabRUniRule annotation
    Gene namesi
    Name:fabRUniRule annotation
    Ordered Locus Names:Ecok1_39410
    ORF Names:APECO1_2500
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215HTH-type transcriptional repressor FabRPRO_0000293567Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405955.APECO1_2500.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AIE5.
    SMRiA1AIE5. Positions 8-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 7061HTH tetR-typeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000270364.
    OrthoDBiEOG6ZPT09.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    HAMAPiMF_01190. HTH_type_FabR.
    InterProiIPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR023764. Tscrpt_reg_HTH_FabR.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1AIE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR    50
    HFRDVDELGL TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG 100
    NNPNAFRLLL RERSGTSAAF RAAVAREIQH FIAELADYLE LENHMPRAFT 150
    EAQAEAMVTI VFSAGAEALD VGVEQRRQLE ERLVLQLRMI SKGAYYWYRR 200
    EQEKTTIIPG NVKDE 215
    Length:215
    Mass (Da):24,434
    Last modified:July 10, 2007 - v2
    Checksum:iACB9729EA947E256
    GO

    Sequence cautioni

    The sequence ABJ03435.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ03435.1. Different initiation.
    RefSeqiYP_859559.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ03435; ABJ03435; APECO1_2500.
    GeneIDi4491447.
    KEGGiecv:APECO1_2500.
    PATRICi18220461. VBIEscCol127180_4440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ03435.1 . Different initiation.
    RefSeqi YP_859559.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1AIE5.
    SMRi A1AIE5. Positions 8-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_2500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ03435 ; ABJ03435 ; APECO1_2500 .
    GeneIDi 4491447.
    KEGGi ecv:APECO1_2500.
    PATRICi 18220461. VBIEscCol127180_4440.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000270364.
    OrthoDBi EOG6ZPT09.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    HAMAPi MF_01190. HTH_type_FabR.
    InterProi IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR023764. Tscrpt_reg_HTH_FabR.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFABR_ECOK1
    AccessioniPrimary (citable) accession number: A1AIE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3