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Protein

HTH-type transcriptional repressor FabR

Gene

fabR

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor FabRUniRule annotation
Gene namesi
Name:fabRUniRule annotation
Ordered Locus Names:Ecok1_39410
ORF Names:APECO1_2500
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008216 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002935671 – 215HTH-type transcriptional repressor FabRAdd BLAST215

Proteomic databases

PRIDEiA1AIE5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1AIE5
SMRiA1AIE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 70HTH tetR-typeUniRule annotationAdd BLAST61

Phylogenomic databases

HOGENOMiHOG000270364
KOiK22105

Family and domain databases

HAMAPiMF_01190 HTH_type_FabR, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR023764 Tscrpt_reg_HTH_FabR
PfamiView protein in Pfam
PF00440 TetR_N, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50977 HTH_TETR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1AIE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR
60 70 80 90 100
HFRDVDELGL TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG
110 120 130 140 150
NNPNAFRLLL RERSGTSAAF RAAVAREIQH FIAELADYLE LENHMPRAFT
160 170 180 190 200
EAQAEAMVTI VFSAGAEALD VGVEQRRQLE ERLVLQLRMI SKGAYYWYRR
210
EQEKTTIIPG NVKDE
Length:215
Mass (Da):24,434
Last modified:July 10, 2007 - v2
Checksum:iACB9729EA947E256
GO

Sequence cautioni

The sequence ABJ03435 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA Translation: ABJ03435.1 Different initiation.
RefSeqiWP_014639518.1, NC_008563.1

Genome annotation databases

EnsemblBacteriaiABJ03435; ABJ03435; APECO1_2500
KEGGiecv:APECO1_2500

Entry informationi

Entry nameiFABR_ECOK1
AccessioniPrimary (citable) accession number: A1AIE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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